{"id":1422,"date":"2026-06-21T20:33:31","date_gmt":"2026-06-21T19:33:31","guid":{"rendered":"http:\/\/seamlessbio.de\/?page_id=1422"},"modified":"2026-06-21T20:39:54","modified_gmt":"2026-06-21T19:39:54","slug":"human-mrp5-vesicle-kit","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/human-mrp5-vesicle-kit\/","title":{"rendered":"MRP5-Vesikel-Kit"},"content":{"rendered":"
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\n Startseite<\/a>\n \/<\/span>\n DMPK Transporter Kit<\/a>\n \/<\/span>\n MRP5 Vesicle Kit<\/strong>\n <\/div>\n\n
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\n SeamlessBio \u2014 Cell4Pharma DMPK Assays<\/span>\n

Human MRP5 Vesicle Kit<\/h1>\n

\n HEK293-derived inside-out membrane vesicles for MRP5 inhibition screening and drug-drug interaction (DDI) risk assessment, in line with FDA and EMA testing recommendations.\n <\/p>\n

\n Informationen anfordern<\/a>\n Im Shop ansehen<\/a>\n <\/div>\n <\/div>\n
\n \"Human\n
Platzhalter f\u00fcr Produktbild<\/div>\n <\/div>\n <\/div>\n\n
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\n 01<\/span>\n

Cyclic Nucleotide Efflux<\/h3>\n

\n Relevant for cyclic nucleotide analogue compounds and cardiovascular drug candidates.\n <\/p>\n <\/div>\n\n

\n 02<\/span>\n

Inside-Out Vesicles<\/h3>\n

\n HEK293-derived membrane vesicles with confirmed MRP5 expression and inside-out orientation for reliable, reproducible transport data.\n <\/p>\n <\/div>\n\n

\n 03<\/span>\n

100 Reactions per Kit<\/h3>\n

\n Each kit is sized for 100 reactions based on a 96-well plate\n format, suitable for IC50 determination and single-concentration\n screening.\n <\/p>\n <\/div>\n\n

\n 04<\/span>\n

Dry Ice Shipment<\/h3>\n

\n Shipped frozen at \u221280 \u00b0C on dry ice to preserve vesicle\n integrity and transport activity upon arrival.\n <\/p>\n <\/div>\n\n <\/div>\n\n

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Why MRP5 testing matters in DMPK programs<\/h2>\n

\n MRP5 (ABCC5) is a cyclic nucleotide efflux transporter with broad tissue expression, including cardiac and vascular smooth muscle tissue.\n <\/p>\n

\n The vesicle-based assay uses cyclic GMP as a probe substrate to quantify MRP5-mediated transport into inside-out membrane vesicles, in the presence and absence of test compounds, allowing determination of inhibition potency and IC50 values.\n <\/p>\n

\n MRP5 inhibition is assessed for compounds with structural similarity to cyclic nucleotide analogues, including certain antiviral and cardiovascular drug candidates. MRP5 testing is typically included in expanded transporter panels rather than the core regulatory set, depending on a candidate compound's structural class and target indication.\n <\/p>\n <\/div>\n\n

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Typical applications<\/h3>\n