{"id":1671,"date":"2026-06-26T16:15:54","date_gmt":"2026-06-26T15:15:54","guid":{"rendered":"http:\/\/seamlessbio.de\/?page_id=1671"},"modified":"2026-07-06T21:34:05","modified_gmt":"2026-07-06T20:34:05","slug":"animal-reproduction","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/animal-reproduction\/","title":{"rendered":"Application Animal Reproduction"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1671\" class=\"elementor elementor-1671\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b10012c e-con e-atomic-element e-flexbox-base e-cb4813e \" data-id=\"b10012c\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"b10012c\">\n    \t\t<div class=\"elementor-element elementor-element-da944e8 elementor-widget elementor-widget-html\" data-id=\"da944e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- 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a{color:#18b7b2;font-size:14px;font-weight:700;text-decoration:none;}.sb-app .cta{padding:54px 34px;border-radius:30px;background:#f7fbfb;border:1px solid rgba(24,183,178,.18);text-align:center;}.sb-app .cta h2{margin:0 0 12px;color:#111;font-size:28px;font-weight:900;}.sb-app .cta p{max-width:760px;margin:0 auto 26px;color:#555;font-size:15px;line-height:1.65;}.sb-app .ctabtns{display:flex;flex-wrap:wrap;gap:14px;justify-content:center;}.sb-app .ctab1,.sb-app .ctab2{display:inline-flex;align-items:center;justify-content:center;min-height:46px;padding:0 28px;border-radius:999px;font-size:13px;font-weight:900;text-transform:uppercase;text-decoration:none!important;transition:all .25s;}.sb-app .ctab1{background:#18b7b2;color:#fff!important;}.sb-app .ctab1:hover{background:#139b97;transform:translateY(-2px);}.sb-app .ctab2{background:transparent;border:2px solid #18b7b2;color:#18b7b2!important;}.sb-app .ctab2:hover{background:#18b7b2;color:#fff!important;transform:translateY(-2px);}@media(max-width:700px){.sb-app{padding:50px 16px 70px;}.sb-app .hero{padding:40px 24px;border-radius:24px;}.sb-app .hero h1{font-size:25px;}.sb-app .hbtns,.sb-app .ctabtns{flex-direction:column;}.sb-app .btn1,.sb-app .btn2,.sb-app .ctab1,.sb-app .ctab2{width:100%;}.sb-app .sec,.sb-app .faq{padding:20px;}.sb-app .cta{padding:36px 20px;}.sb-app .rel-grid{grid-template-columns:1fr;}}<\/style>\n<div class=\"wrap\">\n  <div class=\"bc\"><a href=\"http:\/\/seamlessbio.de\/\">Home<\/a><span>\/<\/span><a href=\"https:\/\/www.seamlessbio.de\/applications\/\">Applications<\/a><span>\/<\/span><strong>Animal Reproduction<\/strong><\/div>\n  <div class=\"hero\">\n    <span class=\"ey\">SeamlessBio \u2014 IVF \u00b7 Oestrus Serum \u00b7 Follicular Fluid \u00b7 DACH<\/span>\n    <h1>Animal Reproduction \u2014 Oestrus Serum, IVF &amp; Follicular Fluid Guide<\/h1>\n    <p class=\"sub\">In vitro fertilisation, embryo transfer, and reproductive cell culture in bovine, equine, porcine, and ovine species require specialised serum formats that standard cell culture suppliers do not carry. Oestrus serum provides the specific hormonal and growth factor composition required for oocyte maturation and early embryo development. SeamlessBio supplies fresh and frozen oestrus serum and species-matched reproductive sera for veterinary IVF and reproductive research.<\/p>\n    <div class=\"hbtns\"><a href=\"mailto:info@seamlessbio.de\" class=\"btn1\">Contact Us<\/a><a href=\"https:\/\/shop.seamlessbio.de\" class=\"btn2\">View in Shop<\/a><\/div>\n  <\/div>\n\n  <div class=\"sec\">\n    <h2>Serum Selection by Reproductive Application<\/h2>\n    <div class=\"tw\">\n      <table>\n        <thead><tr><th>Application<\/th><th>Species<\/th><th>Recommended Serum<\/th><th>Concentration &amp; Role<\/th><\/tr><\/thead>\n        <tbody>\n          <tr><td><strong>Oocyte maturation in vitro (IVM)<\/strong><\/td><td>Bovine, porcine, ovine<\/td><td>Bovine Oestrus Serum (heat-inactivated) or <a href=\"https:\/\/www.seamlessbio.de\/products\/fetal-bovine-serum\/fbs-low-very-low-endotoxin\">FBS Low Endotoxin<\/a><\/td><td>10\u201320% \u2014 oestrus serum provides LH surge-associated factors that support final nuclear maturation of oocytes; FBS Low Endotoxin for standard IVM where oestrus serum is not available<\/td><\/tr>\n          <tr><td><strong>Fertilisation medium (IVF)<\/strong><\/td><td>Bovine, porcine, equine<\/td><td>Bovine Serum Albumin (BSA) \u226598% or species-matched serum<\/td><td>3\u20136 mg\/mL BSA Fatty Acid-Free or 10% species-matched serum \u2014 BSA supports sperm capacitation; serum provides protein matrix for gamete culture<\/td><\/tr>\n          <tr><td><strong>Early embryo culture (IVC)<\/strong><\/td><td>Bovine (day 1\u20138), porcine, ovine<\/td><td><a href=\"https:\/\/www.seamlessbio.de\/products\/fetal-bovine-serum\/fbs-low-very-low-endotoxin\">FBS Low Endotoxin \u22645 EU\/mL<\/a><\/td><td>5\u201310% \u2014 embryo culture medium supplement. Low Endotoxin mandatory \u2014 LPS causes embryo developmental arrest at morula-blastocyst transition.<\/td><\/tr>\n          <tr><td><strong>Equine oocyte IVF<\/strong><\/td><td>Equine<\/td><td><a href=\"https:\/\/www.seamlessbio.de\/products\/animal-sera\/horse-serum-donor-dhs\">Equine Serum<\/a> or Equine Oestrus Serum<\/td><td>10\u201320% \u2014 species-matched serum provides equine-specific factors; bovine serum is often poorly tolerated by equine gametes and embryos<\/td><\/tr>\n          <tr><td><strong>Sperm selection \/ swim-up<\/strong><\/td><td>All species<\/td><td><a href=\"https:\/\/www.seamlessbio.de\/products\/albumin-proteins\/bsa-fatty-acid-free\">BSA Fatty Acid-Free<\/a><\/td><td>0.3\u20135 mg\/mL \u2014 protein supplement in sperm preparation medium; fatty acid-free grade prevents lipid-mediated sperm toxicity<\/td><\/tr>\n          <tr><td><strong>Somatic cell nuclear transfer (SCNT)<\/strong><\/td><td>Bovine<\/td><td><a href=\"https:\/\/www.seamlessbio.de\/products\/fetal-bovine-serum\/fbs-low-very-low-endotoxin\">FBS Low Endotoxin<\/a><\/td><td>10\u201320% \u2014 activation medium and early cloned embryo culture; Low Endotoxin critical for nuclear reprogramming efficiency<\/td><\/tr>\n        <\/tbody>\n      <\/table>\n    <\/div>\n  <\/div>\n\n  <div class=\"sec\">\n    <h2>Available Species-Specific Sera for Reproduction<\/h2>\n    <div class=\"tw\">\n      <table>\n        <thead><tr><th>Species<\/th><th>Serum Format<\/th><th>Application<\/th><th>Product<\/th><\/tr><\/thead>\n        <tbody>\n          <tr><td><strong>Bovine<\/strong><\/td><td>Oestrus Serum (fresh or frozen), NCS, CS, FBS<\/td><td>Bovine IVF\/IVM\/IVC \u2014 the most common veterinary reproductive technology species<\/td><td><a href=\"https:\/\/www.seamlessbio.de\/products\/animal-sera\/bovine-sera-and-more\">Bovine Sera \u2192<\/a><\/td><\/tr>\n          <tr><td><strong>Equine<\/strong><\/td><td>Equine Serum, Donor Horse Serum<\/td><td>Equine IVF, embryo flush media, stallion sperm processing<\/td><td><a href=\"https:\/\/www.seamlessbio.de\/products\/animal-sera\/horse-serum-donor-dhs\">Horse Serum \u2192<\/a><\/td><\/tr>\n          <tr><td><strong>Porcine<\/strong><\/td><td>Pig Serum, FBS<\/td><td>Porcine IVF, embryo culture, reproductive toxicology<\/td><td><a href=\"https:\/\/www.seamlessbio.de\/products\/animal-sera\/pig-serum\">Pig Serum \u2192<\/a><\/td><\/tr>\n          <tr><td><strong>Ovine<\/strong><\/td><td>Lamb Serum, Sheep Serum<\/td><td>Ovine embryo transfer, IVF, early embryo culture<\/td><td><a href=\"https:\/\/www.seamlessbio.de\/products\/animal-sera\/lamb-serum\">Lamb\/Sheep Serum \u2192<\/a><\/td><\/tr>\n        <\/tbody>\n      <\/table>\n    <\/div>\n  <\/div>\n\n  <div class=\"faq\">\n    <h2>Frequently Asked Questions<\/h2>\n    <div class=\"faq-item\"><div class=\"faq-q\">What is oestrus serum and why is it different from standard serum?<\/div><div class=\"faq-a\">Oestrus serum is collected from donor animals during oestrus (the period of sexual receptivity and LH surge). At this hormonal state, serum contains elevated concentrations of LH, FSH, oestradiol, progesterone, and IGF-1 \u2014 growth factors specifically involved in oocyte maturation, follicular rupture, and early embryo development. Standard serum collected from non-oestrus animals lacks these elevated reproductive hormones. For bovine IVM, oestrus serum significantly improves oocyte nuclear maturation rates and subsequent fertilisation success compared to standard serum.<\/div><\/div>\n    <div class=\"faq-item\"><div class=\"faq-q\">Why is Low Endotoxin FBS critical for embryo culture?<\/div><div class=\"faq-a\">Early embryos are extremely sensitive to endotoxin \u2014 LPS causes developmental arrest at the morula-to-blastocyst transition in bovine, porcine, and murine embryos. The mechanism involves TLR4-mediated activation of inflammatory signalling in totipotent blastomeres, which compete with the zygotic gene activation programme. Standard FBS at 10\u2013100 EU\/mL directly reduces blastocyst formation rates in bovine IVC. FBS Low Endotoxin \u22645 EU\/mL eliminates this interference and is the minimum specification for embryo culture applications.<\/div><\/div>\n  <\/div>\n\n  <div class=\"related\"><h3>Related Applications &amp; Products<\/h3><div class=\"rel-grid\">\n    <a href=\"https:\/\/www.seamlessbio.de\/products\/animal-sera\/bovine-sera-and-more\">\u2192 Bovine Sera \u2014 NCS, CS, Oestrus<\/a>\n    <a href=\"https:\/\/www.seamlessbio.de\/products\/animal-sera\/horse-serum-donor-dhs\">\u2192 Equine \/ Horse Serum<\/a>\n    <a href=\"https:\/\/www.seamlessbio.de\/products\/albumin-proteins\/bsa-fatty-acid-free\">\u2192 BSA Fatty Acid-Free<\/a>\n    <a href=\"https:\/\/www.seamlessbio.de\/products\/fetal-bovine-serum\/fbs-low-very-low-endotoxin\">\u2192 FBS Low Endotoxin \u22645 EU\/mL<\/a>\n    <a href=\"https:\/\/www.seamlessbio.de\/products\/animal-sera\/pig-serum\">\u2192 Pig Serum<\/a>\n    <a href=\"https:\/\/www.seamlessbio.de\/products\/animal-sera\/lamb-serum\">\u2192 Lamb Serum<\/a>\n  <\/div><\/div>\n  <\/div>\n  <div class=\"faq\">\n    <h2>More Frequently Asked Questions<\/h2>\n\n    <div class=\"faq-item\">\n      <div class=\"faq-q\">Which serum grade is recommended for bovine embryo culture (IVC)?<\/div>\n      <div class=\"faq-a\">FBS Low Endotoxin \u22645 EU\/mL is the minimum for bovine IVC. Endotoxin causes developmental arrest at the morula-to-blastocyst transition via TLR4 activation in blastomeres. Standard FBS at 10\u2013100 EU\/mL directly reduces blastocyst formation rates. FBS Low Endotoxin at 5\u201310% in SOF or KSOM medium is the standard protocol for commercial and research bovine IVF programmes.<\/div>\n    <\/div>\n    <div class=\"faq-item\">\n      <div class=\"faq-q\">Can BSA replace serum in the fertilisation step of bovine IVF?<\/div>\n      <div class=\"faq-a\">Yes \u2014 <a href=\"https:\/\/www.seamlessbio.de\/products\/albumin-proteins\/bsa-fatty-acid-free\">BSA Fatty Acid-Free<\/a> at 3\u20136 mg\/mL is the standard protein supplement in bovine fertilisation medium (TALP-FERT). BSA supports sperm capacitation without growth factor variability of serum. Fatty acid-free grade is specified \u2014 standard BSA fatty acids are spermicidal in fertilisation droplets. Serum is used in IVM and IVC, not the fertilisation step.<\/div>\n    <\/div>\n    <div class=\"faq-item\">\n      <div class=\"faq-q\">Is oestrus serum available from SeamlessBio for bovine IVM?<\/div>\n      <div class=\"faq-a\">Yes \u2014 bovine oestrus serum (heat-inactivated, sterile-filtered) is available. Collected from donor cows during oestrus, providing LH surge-associated factors for final nuclear maturation of cumulus-oocyte complexes. Available fresh or frozen. Full documentation: origin, collection date, viral screening. Contact info@seamlessbio.de for lot availability and pricing.<\/div>\n    <\/div>\n  <\/div>\n\n  <div class=\"hub-back\"><a href=\"https:\/\/www.seamlessbio.de\/applications\/\">\u2190 All Application Guides Overview<\/a><\/div>\n  <div class=\"cta\"><h2>Request Oestrus Serum &amp; Reproductive Sera Samples<\/h2><p>Species-matched reproductive sera and oestrus serum available. Low Endotoxin grades for embryo culture. Batch reservation for reproductive research programmes.<br>Email: info@seamlessbio.de | +49 851 37932226<\/p>\n  <div class=\"ctabtns\"><a href=\"mailto:info@seamlessbio.de\" class=\"ctab1\">Contact Us<\/a><a href=\"https:\/\/shop.seamlessbio.de\" class=\"ctab2\">View in Shop<\/a><\/div><\/div>\n<\/div>\n\n<script type=\"application\/ld+json\">\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@graph\": [\n    {\n      \"@type\": \"FAQPage\",\n      \"@id\": \"https:\/\/www.seamlessbio.de\/applications\/animal-reproduction#faqpage\",\n      \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is oestrus serum and why is it different from standard serum?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Oestrus serum is collected from donor animals during oestrus (the period of sexual receptivity and LH surge). 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