{"id":1725,"date":"2026-06-26T17:23:31","date_gmt":"2026-06-26T16:23:31","guid":{"rendered":"http:\/\/seamlessbio.de\/?page_id=1725"},"modified":"2026-07-12T15:49:23","modified_gmt":"2026-07-12T14:49:23","slug":"rhsa-uberblick","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/rhsa-overview\/","title":{"rendered":"rHSA \u2013 \u00dcberblick"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1725\" class=\"elementor elementor-1725\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6c333b6 e-con e-atomic-element e-flexbox-base e-99693d1 \" data-id=\"6c333b6\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"6c333b6\" data-e-type=\"e-flexbox\" data-id=\"6c333b6\">\n    \t\t<div class=\"elementor-element elementor-element-64306b2 elementor-widget elementor-widget-html\" data-id=\"64306b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!--\nYOAST SEO\nSlug:      \/rhsa-overview\/\nSEO Title: Recombinant HSA (rHSA) | Economy \u00b7 Premium \u00b7 CHO | SeamlessBio\nMeta Desc: Recombinant Human Serum Albumin in 3 grades \u2014 Economy, Premium and CHO-expressed. Fully xeno-free, yeast or CHO expression. Cell therapy, DMPK, serum-free media. SeamlessBio EU.\nFocus KW:  recombinant human serum albumin rHSA supplier Europe\n-->\n\n<script type=\"application\/ld+json\">\n{\"@context\":\"https:\/\/schema.org\",\"@graph\":[\n{\"@type\":\"BreadcrumbList\",\"itemListElement\":[\n{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/seamlessbio.de\/\"},\n{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Albumin & Proteins\",\"item\":\"https:\/\/seamlessbio.de\/albumin-proteins\/\"},\n{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Recombinant HSA (rHSA)\",\"item\":\"https:\/\/seamlessbio.de\/rhsa-overview\/\"}\n]},\n{\"@type\":\"FAQPage\",\"mainEntity\":[\n{\"@type\":\"Question\",\"name\":\"What is recombinant Human Serum Albumin (rHSA)?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Recombinant HSA (rHSA) is Human Serum Albumin produced by genetic expression in yeast (Pichia pastoris) or CHO cells rather than purified from human plasma. The result is a fully xeno-free albumin with identical sequence to native HSA, no donor variability, no blood-derived contamination risk and consistent lot-to-lot specification.\"}},\n{\"@type\":\"Question\",\"name\":\"What is the difference between rHSA Economy, Premium and CHO-expressed?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"rHSA Economy (yeast): \u226596% purity, \u22645 EU\/mg \u2014 cost-effective for research and process development. rHSA Premium (yeast): \u226599% purity, \u22641 EU\/mg \u2014 for cell therapy formulation and GMP-adjacent applications. rHSA CHO-expressed: highest purity, CHO expression system \u2014 for clinical-stage manufacturing where CHO origin documentation is required.\"}},\n{\"@type\":\"Question\",\"name\":\"Is rHSA truly xeno-free?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Yes \u2014 recombinant HSA expressed in yeast or CHO contains no animal-derived components in the final product. Full xeno-free documentation available for GMP submissions and ATMP ancillary material files.\"}},\n{\"@type\":\"Question\",\"name\":\"When should I use rHSA instead of plasma-derived HSA?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Use rHSA when: xeno-free documentation is required for ATMP\/cell therapy regulatory files; donor variability elimination is critical; no human plasma-derived material is permitted by your quality system; you need highly consistent lot-to-lot albumin for GMP cell therapy formulations. Plasma-derived HSA remains preferred for IVD calibrators and pharmaceutical excipient applications.\"}}\n]}\n]}\n<\/script>\n\n<section class=\"sb-hsaov-page\">\n<div class=\"sb-hsaov-container\">\n\n<nav class=\"sb-hsaov-bc\">\n  <a href=\"https:\/\/seamlessbio.de\/\">Home<\/a><span>\/<\/span>\n  <a href=\"https:\/\/seamlessbio.de\/albumin-proteins\/\">Albumin &amp; Proteins<\/a><span>\/<\/span>\n  <strong>Recombinant HSA (rHSA)<\/strong>\n<\/nav>\n\n<!-- HERO -->\n<div class=\"sb-hsaov-hero\">\n  <div class=\"sb-hsaov-hero-text\">\n    <span class=\"sb-hsaov-eyebrow\">Economy \u00b7 Premium \u00b7 CHO-Expressed \u00b7 Fully Xeno-Free \u00b7 All on Request<\/span>\n    <h1>Recombinant Human Serum Albumin (rHSA)<\/h1>\n    <p>Human Serum Albumin produced by genetic expression \u2014 fully xeno-free, no donor variability, identical sequence to native HSA. Three grades from cost-effective research use to clinical-stage CHO-expressed rHSA for ATMP manufacturing. All products on request.<\/p>\n    <div class=\"sb-hsaov-tags\">\n      <span>rHSA Economy<\/span><span>rHSA Premium<\/span><span>rHSA CHO-Expressed<\/span>\n      <span>Fully Xeno-Free<\/span><span>Yeast &amp; CHO Expression<\/span><span>All on Request<\/span>\n    <\/div>\n    <div class=\"sb-hsaov-btns\">\n      <a href=\"https:\/\/seamlessbio.de\/contact\/\" class=\"sb-hsaov-btn\">Request Information<\/a>\n      <a href=\"https:\/\/seamlessbio.de\/human-serum-albumin\/\" class=\"sb-hsaov-btn-o\">Plasma-Derived HSA \u2192<\/a>\n    <\/div>\n  <\/div>\n<\/div>\n\n<div class=\"sb-hsaov-note\">\n  All rHSA products are available on request. Contact <a href=\"mailto:info@seamlessbio.de\">info@seamlessbio.de<\/a> with your grade, volume and documentation requirements \u2014 48-hour response.\n<\/div>\n\n<!-- 3 GRADES -->\n<div class=\"sb-hsaov-section\">\n  <h2>rHSA by Grade<\/h2>\n  <p class=\"sb-hsaov-intro\">Three grades spanning from cost-effective research albumin to clinical-stage CHO-expressed rHSA. All fully xeno-free \u2014 no animal-derived components in the final product.<\/p>\n\n  <div class=\"sb-hsaov-grade-grid\" style=\"grid-template-columns:repeat(3,1fr)\">\n\n    <div class=\"sb-hsaov-grade\">\n      <div class=\"sb-hsaov-grade-badge g4\">Economy Grade<\/div>\n      <h3>rHSA Economy<\/h3>\n      <p>Yeast-expressed (Pichia pastoris) recombinant HSA at a cost-effective price point. Fully xeno-free for research and early process development. Drop-in replacement for BSA in serum-free media where xeno-free compliance is required.<\/p>\n      <ul class=\"sb-hsaov-ul\">\n        <li>Expression: Yeast (Pichia pastoris)<\/li>\n        <li>Purity: \u226596% (SDS-PAGE)<\/li>\n        <li>Endotoxin: \u22645 EU\/mg (LAL)<\/li>\n        <li>Fully xeno-free \u2014 no animal components<\/li>\n        <li>Research and process development use<\/li>\n      <\/ul>\n      <a href=\"https:\/\/seamlessbio.de\/rhsa-economy\/\" class=\"sb-hsaov-grade-cta\">View rHSA Economy \u2192<\/a>\n    <\/div>\n\n    <div class=\"sb-hsaov-grade\">\n      <div class=\"sb-hsaov-grade-badge g3\">Premium Grade<\/div>\n      <h3>rHSA Premium<\/h3>\n      <p>High-purity yeast-expressed rHSA for cell therapy formulation and GMP-adjacent applications. Tighter endotoxin specification, higher purity and more extensive QC documentation. Standard for serum-free ATMP ancillary material files.<\/p>\n      <ul class=\"sb-hsaov-ul\">\n        <li>Expression: Yeast (Pichia pastoris)<\/li>\n        <li>Purity: \u226599% (SDS-PAGE)<\/li>\n        <li>Endotoxin: \u22641 EU\/mg (LAL)<\/li>\n        <li>Cell therapy formulation and GMP-adjacent<\/li>\n        <li>ATMP ancillary material documentation<\/li>\n      <\/ul>\n      <a href=\"https:\/\/seamlessbio.de\/rhsa-premium\/\" class=\"sb-hsaov-grade-cta\">View rHSA Premium \u2192<\/a>\n    <\/div>\n\n    <div class=\"sb-hsaov-grade\">\n      <div class=\"sb-hsaov-grade-badge g2\">CHO-Expressed<\/div>\n      <h3>rHSA CHO-Expressed<\/h3>\n      <p>Highest purity rHSA produced in CHO mammalian expression system. For clinical-stage manufacturing where CHO origin documentation is required by regulatory agencies. Full GMP documentation package on request.<\/p>\n      <ul class=\"sb-hsaov-ul\">\n        <li>Expression: CHO (mammalian cells)<\/li>\n        <li>Purity: \u226599.5% (SDS-PAGE)<\/li>\n        <li>Endotoxin: \u22640.5 EU\/mg (LAL)<\/li>\n        <li>Clinical-stage manufacturing<\/li>\n        <li>Full GMP documentation on request<\/li>\n      <\/ul>\n      <a href=\"https:\/\/seamlessbio.de\/rhsa-cho-expressed\/\" class=\"sb-hsaov-grade-cta\">View rHSA CHO \u2192<\/a>\n    <\/div>\n\n  <\/div>\n<\/div>\n\n<!-- COMPARISON TABLE -->\n<div class=\"sb-hsaov-section sb-hsaov-alt\">\n  <h2>rHSA vs Plasma-Derived HSA \u2014 Quick Comparison<\/h2>\n  <div style=\"overflow-x:auto;-webkit-overflow-scrolling:touch\">\n  <table style=\"width:100%;border-collapse:collapse;font-size:14px;min-width:560px;margin-top:16px\">\n    <thead><tr style=\"background:#18b7b2;color:#fff\">\n      <th style=\"padding:10px 14px;text-align:left;font-weight:700\">Parameter<\/th>\n      <th style=\"padding:10px 14px;text-align:left;font-weight:700\">rHSA Economy<\/th>\n      <th style=\"padding:10px 14px;text-align:left;font-weight:700\">rHSA Premium<\/th>\n      <th style=\"padding:10px 14px;text-align:left;font-weight:700\">rHSA CHO<\/th>\n      <th style=\"padding:10px 14px;text-align:left;font-weight:700\">HSA Plasma-Derived<\/th>\n    <\/tr><\/thead>\n    <tbody>\n    <tr style=\"border-bottom:1px solid #eee\"><td style=\"padding:10px 14px;font-weight:600;color:#1a2e35\">Source<\/td><td style=\"padding:10px 14px\">Yeast<\/td><td style=\"padding:10px 14px\">Yeast<\/td><td style=\"padding:10px 14px\">CHO cells<\/td><td style=\"padding:10px 14px\">Human plasma<\/td><\/tr>\n    <tr style=\"border-bottom:1px solid #eee;background:#f9fcfc\"><td style=\"padding:10px 14px;font-weight:600;color:#1a2e35\">Xeno-Free<\/td><td style=\"padding:10px 14px\">\u2705 Fully<\/td><td style=\"padding:10px 14px\">\u2705 Fully<\/td><td style=\"padding:10px 14px\">\u2705 Fully<\/td><td style=\"padding:10px 14px\">Human-derived<\/td><\/tr>\n    <tr style=\"border-bottom:1px solid #eee\"><td style=\"padding:10px 14px;font-weight:600;color:#1a2e35\">Purity<\/td><td style=\"padding:10px 14px\">\u226596%<\/td><td style=\"padding:10px 14px\">\u226599%<\/td><td style=\"padding:10px 14px\">\u226599.5%<\/td><td style=\"padding:10px 14px\">Grade-dependent<\/td><\/tr>\n    <tr style=\"border-bottom:1px solid #eee;background:#f9fcfc\"><td style=\"padding:10px 14px;font-weight:600;color:#1a2e35\">Endotoxin<\/td><td style=\"padding:10px 14px\">\u22645 EU\/mg<\/td><td style=\"padding:10px 14px\">\u22641 EU\/mg<\/td><td style=\"padding:10px 14px\">\u22640.5 EU\/mg<\/td><td style=\"padding:10px 14px\">\u22645 EU\/mg<\/td><\/tr>\n    <tr style=\"border-bottom:1px solid #eee\"><td style=\"padding:10px 14px;font-weight:600;color:#1a2e35\">Lot variability<\/td><td style=\"padding:10px 14px\">Very low<\/td><td style=\"padding:10px 14px\">Very low<\/td><td style=\"padding:10px 14px\">Minimal<\/td><td style=\"padding:10px 14px\">Some donor variation<\/td><\/tr>\n    <tr style=\"border-bottom:1px solid #eee;background:#f9fcfc\"><td style=\"padding:10px 14px;font-weight:600;color:#1a2e35\">Best for<\/td><td style=\"padding:10px 14px\">Research, process dev.<\/td><td style=\"padding:10px 14px\">Cell therapy, GMP-adj.<\/td><td style=\"padding:10px 14px\">Clinical manufacturing<\/td><td style=\"padding:10px 14px\">IVD, pharma excipient<\/td><\/tr>\n    <\/tbody>\n  <\/table>\n  <\/div>\n<\/div>\n\n<!-- APPLICATIONS -->\n<div class=\"sb-hsaov-section\">\n  <h2>Applications<\/h2>\n  <div class=\"sb-hsaov-liq-grid\">\n    <div class=\"sb-hsaov-liq\">\n      <h3>Serum-Free Cell Culture<\/h3>\n      <p>rHSA as xeno-free albumin supplement in serum-free and protein-free media formulations. Stabilises growth factors and provides carrier function without animal serum or plasma-derived components.<\/p>\n      <div class=\"sb-hsaov-liq-specs\">Economy or Premium grade \u00b7 0.5\u201310 g\/L typical concentration<\/div>\n    <\/div>\n    <div class=\"sb-hsaov-liq\">\n      <h3>ATMP & Cell Therapy Formulation<\/h3>\n      <p>rHSA Premium or CHO-expressed for ATMP ancillary material files where xeno-free documentation is required. CAR-T final formulation, MSC cryopreservation and iPSC media supplementation.<\/p>\n      <div class=\"sb-hsaov-liq-specs\">Premium or CHO grade \u00b7 ISO 13485 documentation \u00b7 EMA\/410\/01 compliant<\/div>\n    <\/div>\n    <div class=\"sb-hsaov-liq\">\n      <h3>DMPK & Protein Binding<\/h3>\n      <p>rHSA for plasma protein binding assays in drug metabolism studies. Defined fatty acid content for reproducible PPB results. Contact us for fatty acid-free rHSA specification.<\/p>\n      <div class=\"sb-hsaov-liq-specs\">Economy grade \u00b7 Defined lot-to-lot \u00b7 No donor variability<\/div>\n    <\/div>\n  <\/div>\n<\/div>\n\n<!-- FAQ -->\n<div class=\"sb-hsaov-section\">\n  <h2>Frequently Asked Questions<\/h2>\n\n  <div class=\"sb-pp-faq-item\" style=\"border-bottom:1px solid #e8f0ef;padding:18px 0\">\n    <h3 style=\"font-size:16px;font-weight:700;color:#1a2e35;margin:0 0 8px\">What is rHSA and how is it different from plasma-derived HSA?<\/h3>\n    <p style=\"font-size:15px;color:#555;margin:0;line-height:1.7\">rHSA is produced by genetic expression in yeast or CHO cells \u2014 no human plasma required. Fully xeno-free, no donor variability, no blood-derived contamination risk. Identical amino acid sequence to native human albumin.<\/p>\n  <\/div>\n\n  <div class=\"sb-pp-faq-item\" style=\"border-bottom:1px solid #e8f0ef;padding:18px 0\">\n    <h3 style=\"font-size:16px;font-weight:700;color:#1a2e35;margin:0 0 8px\">Which grade should I choose?<\/h3>\n    <p style=\"font-size:15px;color:#555;margin:0;line-height:1.7\">Economy for research and process development. Premium for cell therapy formulation and GMP-adjacent applications. CHO-expressed for clinical-stage manufacturing where CHO origin documentation is required.<\/p>\n  <\/div>\n\n  <div class=\"sb-pp-faq-item\" style=\"border-bottom:1px solid #e8f0ef;padding:18px 0\">\n    <h3 style=\"font-size:16px;font-weight:700;color:#1a2e35;margin:0 0 8px\">Is rHSA suitable for ATMP ancillary material files?<\/h3>\n    <p style=\"font-size:15px;color:#555;margin:0;line-height:1.7\">Yes \u2014 rHSA Premium and CHO-expressed come with ATMP ancillary material documentation on request. Fully xeno-free \u2014 compliant with EMA\/410\/01 guidance for xeno-free ATMP manufacturing.<\/p>\n  <\/div>\n\n  <div class=\"sb-pp-faq-item\" style=\"border-bottom:1px solid #e8f0ef;padding:18px 0\">\n    <h3 style=\"font-size:16px;font-weight:700;color:#1a2e35;margin:0 0 8px\">When should I use HSA instead of rHSA?<\/h3>\n    <p style=\"font-size:15px;color:#555;margin:0;line-height:1.7\">Plasma-derived HSA is preferred for IVD calibrators and pharmaceutical excipient applications where pharmacopoeial (Ph. Eur.\/USP) compliance is required. rHSA is preferred for ATMP and cell therapy where xeno-free documentation is required.<\/p>\n  <\/div>\n<\/div>\n\n<!-- RELATED -->\n<div class=\"sb-hsaov-section sb-hsaov-alt\">\n  <h2>Related Products<\/h2>\n  <div class=\"sb-hsaov-related\">\n    <a href=\"https:\/\/seamlessbio.de\/rhsa-economy\/\" class=\"sb-hsaov-rel\"><h3>rHSA Economy<\/h3><p>Cost-effective yeast-expressed rHSA for research and process development.<\/p><\/a>\n    <a href=\"https:\/\/seamlessbio.de\/rhsa-premium\/\" class=\"sb-hsaov-rel\"><h3>rHSA Premium<\/h3><p>High-purity yeast rHSA for cell therapy formulation and GMP-adjacent use.<\/p><\/a>\n    <a href=\"https:\/\/seamlessbio.de\/rhsa-cho-expressed\/\" class=\"sb-hsaov-rel\"><h3>rHSA CHO-Expressed<\/h3><p>Highest purity CHO-expressed rHSA for clinical-stage manufacturing.<\/p><\/a>\n    <a href=\"https:\/\/seamlessbio.de\/human-serum-albumin\/\" class=\"sb-hsaov-rel\"><h3>HSA \u2014 Plasma-Derived<\/h3><p>4 grades: Excipient, Diagnostic, Cell Culture, Research.<\/p><\/a>\n  <\/div>\n<\/div>\n\n<!-- CTA -->\n<div class=\"sb-hsaov-cta\">\n  <h2>All rHSA Products \u2014 On Request<\/h2>\n  <p>Contact us with your grade, volume and documentation requirements. Free test samples available. 48-hour response.<\/p>\n  <div class=\"sb-hsaov-cta-btns\">\n    <a href=\"https:\/\/seamlessbio.de\/contact\/\" class=\"sb-hsaov-btn-w\">Contact Us<\/a>\n    <a href=\"mailto:info@seamlessbio.de?subject=rHSA%20Enquiry\" class=\"sb-hsaov-btn-oo\">info@seamlessbio.de<\/a>\n  <\/div>\n<\/div>\n\n<\/div>\n<\/section>\n\n<style>\n.sb-hsaov-page,.sb-hsaov-page *,.sb-hsaov-page *::before,.sb-hsaov-page *::after{box-sizing:border-box}\n.sb-hsaov-page{font-family:Arial,sans-serif;color:#1a1a1a;background:#fff;padding:60px 32px 90px}\n.sb-hsaov-container{max-width:1200px;margin:0 auto}\n.sb-hsaov-bc{display:flex;flex-wrap:wrap;gap:6px;align-items:center;font-size:13px;color:#888;margin-bottom:28px}\n.sb-hsaov-bc a{color:#18b7b2!important;text-decoration:none!important;font-weight:600}.sb-hsaov-bc strong{color:#111}.sb-hsaov-bc span{color:#ccc}\n.sb-hsaov-hero{background:linear-gradient(135deg,#0d9490 0%,#18b7b2 60%,#1ec8c2 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