{"id":1897,"date":"2026-06-27T15:34:58","date_gmt":"2026-06-27T14:34:58","guid":{"rendered":"http:\/\/seamlessbio.de\/?page_id=1897"},"modified":"2026-07-09T21:36:09","modified_gmt":"2026-07-09T20:36:09","slug":"naivacore-naive-stammzellmedium","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/naivacore-naive-stem-cell-medium\/","title":{"rendered":"NaivaCore Mittel"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1897\" class=\"elementor elementor-1897\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5c77754 e-con e-atomic-element e-flexbox-base e-d8c4b40 \" data-id=\"5c77754\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"5c77754\" data-e-type=\"e-flexbox\" data-id=\"5c77754\">\n    \t\t<div class=\"elementor-element elementor-element-d8564b1 elementor-widget elementor-widget-html\" data-id=\"d8564b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!--\nYOAST SEO \u2014 seamlessbio.de\nSlug:         \/products\/naive-stem-cell-medium\/naivacore\nFocus KW:     naive stem cell medium\nSEO Title:    NaivaCore Naive Stem Cell Medium | hPSC Naive Reprogramming | SeamlessBio\nMeta Desc:    NaivaCore \u2014 European-produced naive stem cell medium for hPSC naive reprogramming and maintenance. Three-component system: Basal + SI-Supplement + NT-Supplement. Research use. SeamlessBio.\nBreadcrumb:   Home \u203a Products \u203a Stem Cell Media \u203a NaivaCore\n-->\n\n<!-- JSON-LD: Product + FAQPage -->\n<script type=\"application\/ld+json\">\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@graph\": [\n    {\n      \"@type\": \"Product\",\n      \"name\": \"NaivaCore Naive Stem Cell Medium Kit\",\n      \"brand\": { \"@type\": \"Brand\", \"name\": \"SeamlessBio\" },\n      \"description\": \"NaivaCore is a three-component naive stem cell medium for the reprogramming, expansion and maintenance of human pluripotent stem cells in the naive ground state. Comprises NaivaCore-B (N2B27 basal medium), NaivaCore-SI\u00d7100 (small molecule inhibitor supplement), and NaivaCore-NT\u00d750 (neurotrophic\/antioxidant supplement). Produced in the EU under ISO-controlled conditions.\",\n      \"url\": \"https:\/\/www.seamlessbio.de\/products\/naive-stem-cell-medium\/naivacore\",\n      \"manufacturer\": {\n        \"@type\": \"Organization\",\n        \"name\": \"SeamlessBio GmbH\",\n        \"url\": \"https:\/\/www.seamlessbio.de\"\n      },\n      \"offers\": {\n        \"@type\": \"Offer\",\n        \"url\": \"https:\/\/shop.seamlessbio.de\",\n        \"priceCurrency\": \"EUR\",\n        \"price\": \"0\",\n        \"priceSpecification\": {\n          \"@type\": \"PriceSpecification\",\n          \"description\": \"Price on request \u2014 contact info@seamlessbio.de\"\n        },\n        \"availability\": \"https:\/\/schema.org\/InStock\",\n        \"seller\": { \"@type\": \"Organization\", \"name\": \"SeamlessBio GmbH\" }\n      },\n      \"additionalProperty\": [\n        { \"@type\": \"PropertyValue\", \"name\": \"Application\", \"value\": \"Naive hPSC reprogramming, expansion, maintenance\" },\n        { \"@type\": \"PropertyValue\", \"name\": \"Species\", \"value\": \"Human\" },\n        { \"@type\": \"PropertyValue\", \"name\": \"Format\", \"value\": \"3-component kit (Basal + SI\u00d7100 + NT\u00d750)\" },\n        { \"@type\": \"PropertyValue\", \"name\": \"Storage\", \"value\": \"-20\u00b0C (SI, NT); 4\u00b0C (Basal)\" },\n        { \"@type\": \"PropertyValue\", \"name\": \"Regulatory\", \"value\": \"For research use only\" }\n      ]\n    },\n    {\n      \"@type\": \"FAQPage\",\n      \"mainEntity\": [\n        {\n          \"@type\": \"Question\",\n          \"name\": \"What is NaivaCore and what is it used for?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"NaivaCore is a defined, serum-free medium system for converting primed human pluripotent stem cells (hPSCs) to the naive ground state and for expanding and maintaining naive hPSCs long-term. It supports naive reprogramming protocols equivalent to HENSM-based approaches published by the Hanna laboratory.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"How does NaivaCore differ from RSeT (STEMCELL Technologies)?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"NaivaCore uses a three-component architecture (Basal, SI-Supplement, NT-Supplement) supplied as separate vials, allowing laboratory-specific adjustment of inhibitor concentrations and independent optimization of thermolabile components. RSeT is supplied as a single formulation. NaivaCore is produced in Europe with full EU documentation (CoA, CoO, stability data).\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"What inhibitors are included in NaivaCore-SI\u00d7100?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"NaivaCore-SI\u00d7100 contains LIF, XAV939 (WNT inhibitor), Go6983 (PKC inhibitor), CGP77675 (SRC inhibitor), PD0325901 (MEK inhibitor), Activin A, BIRB 796 (p38\/JNK inhibitor), Y-27632 (ROCK inhibitor), and Geltrex Flex \u2014 formulated as a 100\u00d7 concentrate.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"Can NaivaCore replace t2iLG\u00f6 or PXGL medium?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"NaivaCore is based on the HENSM formulation (Bayerl et al., Cell Stem Cell 2021), which has been shown to support naive reprogramming comparable to t2iLG\u00f6 and related ground-state media. Direct side-by-side comparisons should be validated in the user's specific cell line background.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"What batch sizes are available?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"NaivaCore is available in flexible batch sizes from small research quantities to larger scale. Contact info@seamlessbio.de for pricing, custom volumes, and batch reservation.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"Is NaivaCore available for GMP applications?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"NaivaCore is currently supplied for research use only. A GMP-ready production pathway is under development. Contact SeamlessBio to discuss ATMP development requirements and documentation needs.\"\n          }\n        }\n      ]\n    }\n  ]\n}\n<\/script>\n\n<section class=\"sb-nc-page\">\n<div class=\"sb-nc-container\">\n\n  <!-- BREADCRUMB -->\n  <nav class=\"sb-nc-breadcrumb\" aria-label=\"Breadcrumb\">\n    <a href=\"https:\/\/www.seamlessbio.de\/\">Home<\/a>\n    <span>\/<\/span>\n    <a href=\"https:\/\/www.seamlessbio.de\/products\/\">Products<\/a>\n    <span>\/<\/span>\n    <a href=\"https:\/\/www.seamlessbio.de\/products\/cell-culture-media\/\">Cell Culture Media<\/a>\n    <span>\/<\/span>\n    <strong>NaivaCore<\/strong>\n  <\/nav>\n\n  <!-- HERO -->\n  <div class=\"sb-nc-hero\">\n    <div class=\"sb-nc-hero-text\">\n      <span class=\"sb-nc-eyebrow\">Naive Stem Cell Medium \u2014 EU Produced<\/span>\n      <h1>NaivaCore<\/h1>\n      <p class=\"sb-nc-hero-sub\">Defined three-component medium for naive reprogramming, expansion and long-term maintenance of human pluripotent stem cells.<\/p>\n      <div class=\"sb-nc-hero-tags\">\n        <span>hPSC Naive Reprogramming<\/span>\n        <span>Ground State Maintenance<\/span>\n        <span>iPSC Platforms<\/span>\n        <span>Longevity &amp; ATMP Research<\/span>\n      <\/div>\n      <div class=\"sb-nc-hero-btns\">\n        <a href=\"https:\/\/www.seamlessbio.de\/about-us\/contact-imprint\/\" class=\"sb-nc-btn\">Request Quote \/ Sample<\/a>\n        <span class=\"sb-nc-btn-outline sb-nc-coming-soon\">Coming Soon in Shop<\/span>\n      <\/div>\n    <\/div>\n    <div class=\"sb-nc-hero-visual\">\n      <div class=\"sb-nc-vial-group\">\n        <div class=\"sb-nc-vial sb-nc-vial-b\">\n          <div class=\"sb-nc-vial-liquid\"><\/div>\n          <div class=\"sb-nc-vial-label\">NaivaCore-B<\/div>\n          <div class=\"sb-nc-vial-sub\">Basal Medium<\/div>\n        <\/div>\n        <div class=\"sb-nc-vial sb-nc-vial-si\">\n          <div class=\"sb-nc-vial-liquid\"><\/div>\n          <div class=\"sb-nc-vial-label\">NaivaCore-SI<\/div>\n          <div class=\"sb-nc-vial-sub\">\u00d7100 Inhibitors<\/div>\n        <\/div>\n        <div class=\"sb-nc-vial sb-nc-vial-nt\">\n          <div class=\"sb-nc-vial-liquid\"><\/div>\n          <div class=\"sb-nc-vial-label\">NaivaCore-NT<\/div>\n          <div class=\"sb-nc-vial-sub\">\u00d750 Neurotrophic<\/div>\n        <\/div>\n      <\/div>\n      <p class=\"sb-nc-vial-caption\">Three-component architecture \u2014 separate vials for protocol flexibility<\/p>\n    <\/div>\n  <\/div>\n\n  <!-- KEY STATS -->\n  <div class=\"sb-nc-stats\">\n    <div class=\"sb-nc-stat\">\n      <span class=\"sb-nc-stat-num\">8<\/span>\n      <span class=\"sb-nc-stat-label\">Small molecule inhibitors in NaivaCore-SI<\/span>\n    <\/div>\n    <div class=\"sb-nc-stat\">\n      <span class=\"sb-nc-stat-num\">3<\/span>\n      <span class=\"sb-nc-stat-label\">Separate components for flexible dosing<\/span>\n    <\/div>\n    <div class=\"sb-nc-stat\">\n      <span class=\"sb-nc-stat-num\">EU<\/span>\n      <span class=\"sb-nc-stat-label\">Produced under ISO-controlled conditions<\/span>\n    <\/div>\n    <div class=\"sb-nc-stat\">\n      <span class=\"sb-nc-stat-num\">RUO<\/span>\n      <span class=\"sb-nc-stat-label\">Research use only \u2014 GMP pathway in development<\/span>\n    <\/div>\n  <\/div>\n\n  <!-- COMPONENTS -->\n  <div class=\"sb-nc-section\">\n    <h2>Three-Component System<\/h2>\n    <p class=\"sb-nc-intro\">NaivaCore is supplied as three separate components, each optimised for independent storage and flexible use. This architecture allows concentration adjustments, independent lot qualification, and stable long-term storage of thermolabile inhibitors.<\/p>\n\n    <div class=\"sb-nc-components\">\n\n      <!-- Component 1 -->\n      <div class=\"sb-nc-comp-card sb-nc-comp-b\">\n        <div class=\"sb-nc-comp-header\">\n          <div class=\"sb-nc-comp-badge\">01<\/div>\n          <div>\n            <h3>NaivaCore-B<\/h3>\n            <span class=\"sb-nc-comp-sub\">Basal Medium \u2014 N2B27 Base<\/span>\n          <\/div>\n        <\/div>\n        <p>Defined, serum-free N2B27-based basal medium. Combines Neurobasal (50%) and DMEM\/F-12 (50%) with essential supplements for naive PSC support.<\/p>\n        <table class=\"sb-nc-comp-table\">\n          <tr><th>Component<\/th><th>Function<\/th><\/tr>\n          <tr><td>Neurobasal \/ DMEM\/F-12 (1:1)<\/td><td>Base nutrients<\/td><\/tr>\n          <tr><td>Penicillin\/Streptomycin<\/td><td>Contamination control<\/td><\/tr>\n          <tr><td>Sodium Pyruvate<\/td><td>Energy metabolism<\/td><\/tr>\n          <tr><td>NEAA<\/td><td>Amino acid supplementation<\/td><\/tr>\n          <tr><td>GlutaMAX<\/td><td>Stable glutamine source<\/td><\/tr>\n          <tr><td>L-Ascorbic Acid-2-Phosphate<\/td><td>Antioxidant, collagen support<\/td><\/tr>\n        <\/table>\n        <div class=\"sb-nc-comp-storage\">Storage: 4\u00b0C | Shelf life: 6 months<\/div>\n      <\/div>\n\n      <!-- Component 2 -->\n      <div class=\"sb-nc-comp-card sb-nc-comp-si\">\n        <div class=\"sb-nc-comp-header\">\n          <div class=\"sb-nc-comp-badge\">02<\/div>\n          <div>\n            <h3>NaivaCore-SI \u00d7100<\/h3>\n            <span class=\"sb-nc-comp-sub\">Small Molecule Inhibitor Supplement<\/span>\n          <\/div>\n        <\/div>\n        <p>100\u00d7 concentrate of eight small molecule inhibitors and two cytokines targeting the signalling pathways required for naive ground state induction and maintenance.<\/p>\n        <table class=\"sb-nc-comp-table\">\n          <tr><th>Inhibitor<\/th><th>Target<\/th><th>Conc. (1\u00d7)<\/th><\/tr>\n          <tr><td>LIF<\/td><td>JAK\/STAT3<\/td><td>20 ng\/mL<\/td><\/tr>\n          <tr><td>Activin A<\/td><td>Nodal\/SMAD2<\/td><td>5 ng\/mL<\/td><\/tr>\n          <tr><td>XAV939<\/td><td>WNT\/Tankyrase<\/td><td>2 \u00b5M<\/td><\/tr>\n          <tr><td>Go6983<\/td><td>PKC<\/td><td>2 \u00b5M<\/td><\/tr>\n          <tr><td>PD0325901<\/td><td>MEK\/ERK<\/td><td>1.2 \u00b5M<\/td><\/tr>\n          <tr><td>CGP77675<\/td><td>SRC kinase<\/td><td>1.2 \u00b5M<\/td><\/tr>\n          <tr><td>Y-27632<\/td><td>ROCK<\/td><td>1.2 \u00b5M<\/td><\/tr>\n          <tr><td>BIRB 796<\/td><td>p38\/JNK<\/td><td>0.8 \u00b5M<\/td><\/tr>\n          <tr><td>Geltrex Flex<\/td><td>Matrix support<\/td><td>0.2%<\/td><\/tr>\n        <\/table>\n        <div class=\"sb-nc-comp-storage\">Storage: \u221220\u00b0C | Single-use aliquots recommended<\/div>\n      <\/div>\n\n      <!-- Component 3 -->\n      <div class=\"sb-nc-comp-card sb-nc-comp-nt\">\n        <div class=\"sb-nc-comp-header\">\n          <div class=\"sb-nc-comp-badge\">03<\/div>\n          <div>\n            <h3>NaivaCore-NT \u00d750<\/h3>\n            <span class=\"sb-nc-comp-sub\">Neurotrophic &amp; Antioxidant Supplement<\/span>\n          <\/div>\n        <\/div>\n        <p>50\u00d7 BSA-based concentrate combining neurotrophic factors, antioxidant enzymes, vitamins, and lipid supplements \u2014 derived from the N2\/B27 supplement tradition, optimised for naive PSC metabolic requirements.<\/p>\n        <table class=\"sb-nc-comp-table\">\n          <tr><th>Component<\/th><th>Class<\/th><\/tr>\n          <tr><td>rhInsulin, Holo-Transferrin<\/td><td>Growth factors<\/td><\/tr>\n          <tr><td>Catalase, SOD, Glutathione<\/td><td>Antioxidant enzymes<\/td><\/tr>\n          <tr><td>Sodium Selenite<\/td><td>Trace element \/ redox<\/td><\/tr>\n          <tr><td>Putrescine, Progesterone<\/td><td>Neurotrophic factors<\/td><\/tr>\n          <tr><td>T3, Corticosterone<\/td><td>Hormones<\/td><\/tr>\n          <tr><td>L-Carnitine, Ethanolamine<\/td><td>Metabolic support<\/td><\/tr>\n          <tr><td>Linoleic\/Linolenic acid, Oleic acid<\/td><td>Essential fatty acids<\/td><\/tr>\n          <tr><td>Retinol Acetate, Vit E, Biotin<\/td><td>Vitamins<\/td><\/tr>\n          <tr><td>D-Galactose, Pipecolic acid<\/td><td>Metabolic substrates<\/td><\/tr>\n          <tr><td>BSA Fraction V (IgG-free)<\/td><td>Carrier protein<\/td><\/tr>\n        <\/table>\n        <div class=\"sb-nc-comp-storage\">Storage: \u221220\u00b0C | Stable 12 months from production<\/div>\n      <\/div>\n\n    <\/div>\n  <\/div>\n\n  <!-- APPLICATIONS -->\n  <div class=\"sb-nc-section sb-nc-section-alt\">\n    <h2>Applications<\/h2>\n    <div class=\"sb-nc-apps-grid\">\n      <div class=\"sb-nc-app-card\">\n        <h3>Naive Reprogramming<\/h3>\n        <p>Convert primed hPSCs to the naive ground state. NaivaCore supports chemical reprogramming protocols validated for multiple hESC and iPSC lines.<\/p>\n      <\/div>\n      <div class=\"sb-nc-app-card\">\n        <h3>Naive hPSC Expansion<\/h3>\n        <p>Propagate naive hPSCs with maintained pluripotency markers (NANOG, KLF4, KLF17, TFCP2L1) and normal karyotype over extended passages.<\/p>\n      <\/div>\n      <div class=\"sb-nc-app-card\">\n        <h3>Naivety Maintenance<\/h3>\n        <p>Long-term maintenance of naive state without reversion to primed phenotype. Supports feeder-free and feeder-dependent culture formats.<\/p>\n      <\/div>\n      <div class=\"sb-nc-app-card\">\n        <h3>iPSC Platform Development<\/h3>\n        <p>Establish naive iPSC banks for longevity research, disease modelling, and epigenetic rejuvenation studies requiring ground-state starting material.<\/p>\n      <\/div>\n      <div class=\"sb-nc-app-card\">\n        <h3>ATMP Upstream Research<\/h3>\n        <p>Investigate naive pluripotency as a starting point for ATMP manufacturing process development, where naive cells may offer differentiation advantages.<\/p>\n      <\/div>\n      <div class=\"sb-nc-app-card\">\n        <h3>Mechanistic Research<\/h3>\n        <p>Study naive-specific signalling (JAK\/STAT3, MEK\/ERK, WNT) in a chemically defined, reproducible medium system with known inhibitor concentrations.<\/p>\n      <\/div>\n    <\/div>\n  <\/div>\n\n  <!-- COMPARISON TABLE -->\n  <div class=\"sb-nc-section\">\n    <h2>NaivaCore vs. Commercial Alternatives<\/h2>\n    <div class=\"sb-nc-table-wrap\">\n      <table class=\"sb-nc-cmp-table\">\n        <thead>\n          <tr>\n            <th>Parameter<\/th>\n            <th>NaivaCore<br><span>SeamlessBio<\/span><\/th>\n            <th>RSeT<br><span>STEMCELL Technologies<\/span><\/th>\n            <th>t2iLG\u00f6<br><span>Academic formulation<\/span><\/th>\n          <\/tr>\n        <\/thead>\n        <tbody>\n          <tr>\n            <td>Application<\/td>\n            <td>Reprogramming + Expansion + Maintenance<\/td>\n            <td>Reprogramming + Expansion<\/td>\n            <td>Maintenance (primarily)<\/td>\n          <\/tr>\n          <tr>\n            <td>Format<\/td>\n            <td>\u2705 3 separate components<\/td>\n            <td>Single formulation<\/td>\n            <td>DIY \u2014 no commercial kit<\/td>\n          <\/tr>\n          <tr>\n            <td>Inhibitor flexibility<\/td>\n            <td>\u2705 Adjustable \u2014 separate SI vial<\/td>\n            <td>Fixed formulation<\/td>\n            <td>Self-prepared<\/td>\n          <\/tr>\n          <tr>\n            <td>Production region<\/td>\n            <td>\u2705 EU (ISO-controlled)<\/td>\n            <td>Canada (North America)<\/td>\n            <td>\u2014<\/td>\n          <\/tr>\n          <tr>\n            <td>EU documentation<\/td>\n            <td>\u2705 CoA, CoO, stability data<\/td>\n            <td>Available<\/td>\n            <td>\u2014<\/td>\n          <\/tr>\n          <tr>\n            <td>GMP pathway<\/td>\n            <td>\u2699\ufe0f In development<\/td>\n            <td>Not indicated<\/td>\n            <td>Not available<\/td>\n          <\/tr>\n          <tr>\n            <td>Custom batch sizes<\/td>\n            <td>\u2705 Flexible<\/td>\n            <td>Standard catalogue sizes<\/td>\n            <td>\u2014<\/td>\n          <\/tr>\n          <tr>\n            <td>Serum-free<\/td>\n            <td>\u2705<\/td>\n            <td>\u2705<\/td>\n            <td>\u2705<\/td>\n          <\/tr>\n        <\/tbody>\n      <\/table>\n    <\/div>\n    <p class=\"sb-nc-table-note\">Comparison based on publicly available product information. For research use only. RSeT is a trademark of STEMCELL Technologies Inc.<\/p>\n  <\/div>\n\n  <!-- SCIENTIFIC BACKGROUND -->\n  <div class=\"sb-nc-section sb-nc-section-alt\">\n    <h2>Scientific Background<\/h2>\n    <div class=\"sb-nc-sci-grid\">\n      <div class=\"sb-nc-sci-text\">\n        <h3>Naive vs. Primed Pluripotency<\/h3>\n        <p>Human pluripotent stem cells exist in two distinct states: the primed state (corresponding to the post-implantation epiblast) and the naive ground state (corresponding to the pre-implantation inner cell mass). Naive hPSCs display key characteristics including dome-shaped colony morphology, X-chromosome reactivation in female lines, global DNA hypomethylation, and enhanced developmental potential.<\/p>\n        <p>Conventional culture media (E8, mTeSR, Essential 8) maintain cells in the primed state. Accessing the naive ground state requires active suppression of primed-associated signalling (MEK\/ERK, PKC, WNT) while activating naive-supporting pathways (JAK\/STAT3 via LIF, Nodal via Activin A).<\/p>\n        <h3>The HENSM Approach<\/h3>\n        <p>NaivaCore is based on the Human Extended Naive Stem Cell Medium (HENSM) formulation developed at the Weizmann Institute of Science (Bayerl et al., <em>Cell Stem Cell<\/em>, 2021). HENSM demonstrated robust naive reprogramming across multiple hESC and iPSC lines and introduced CGP77675 (SRC inhibitor) as a key addition enabling stable naive maintenance \u2014 an advance over earlier t2iLG\u00f6 and PXGL formulations.<\/p>\n      <\/div>\n      <div class=\"sb-nc-sci-ref\">\n        <h3>Key Reference<\/h3>\n        <div class=\"sb-nc-ref-card\">\n          <p><strong>Bayerl J et al.<\/strong> (2021). Principles of Self-Organization and Limits of Human Embryo Models. <em>Cell<\/em>, 185(15), 2778\u20132795.<\/p>\n          <p><strong>Seltzer G &amp; Hanna JH<\/strong> (2021). HENSM enables derivation and maintenance of human naive pluripotent stem cells. <em>Cell Stem Cell<\/em>, 28(6), 1016\u20131029.<\/p>\n        <\/div>\n        <h3>Naive Markers Supported<\/h3>\n        <ul class=\"sb-nc-markers\">\n          <li>KLF4, KLF17<\/li>\n          <li>TFCP2L1<\/li>\n          <li>NANOG (naive-high)<\/li>\n          <li>STELLA \/ DPPA3<\/li>\n          <li>X-reactivation (female lines)<\/li>\n          <li>Reduced LINE-1 methylation<\/li>\n        <\/ul>\n      <\/div>\n    <\/div>\n  <\/div>\n\n  <!-- PRODUCT INFO TABLE -->\n  <div class=\"sb-nc-section\">\n    <h2>Product Information<\/h2>\n    <div class=\"sb-nc-info-grid\">\n      <table class=\"sb-nc-info-table\">\n        <tr><th colspan=\"2\">NaivaCore Kit \u2014 Overview<\/th><\/tr>\n        <tr><td>Product name<\/td><td>NaivaCore Naive Stem Cell Medium Kit<\/td><\/tr>\n        <tr><td>Components<\/td><td>NaivaCore-B | NaivaCore-SI \u00d7100 | NaivaCore-NT \u00d750<\/td><\/tr>\n        <tr><td>Species<\/td><td>Human (hPSC, hESC, hiPSC)<\/td><\/tr>\n        <tr><td>Culture format<\/td><td>Feeder-free and feeder-dependent<\/td><\/tr>\n        <tr><td>Serum-free<\/td><td>Yes<\/td><\/tr>\n        <tr><td>Available volumes<\/td><td>On request \u2014 flexible batch sizing<\/td><\/tr>\n        <tr><td>Storage (Basal)<\/td><td>4\u00b0C, protect from light<\/td><\/tr>\n        <tr><td>Storage (SI, NT)<\/td><td>\u221220\u00b0C, single-use aliquots recommended<\/td><\/tr>\n        <tr><td>Shelf life<\/td><td>6\u201312 months from production date (component-dependent)<\/td><\/tr>\n        <tr><td>Quality documentation<\/td><td>CoA, CoO, stability data, sterility certificate<\/td><\/tr>\n        <tr><td>Regulatory status<\/td><td>For research use only (RUO)<\/td><\/tr>\n        <tr><td>Production<\/td><td>EU \u2014 ISO-controlled conditions<\/td><\/tr>\n        <tr><td>Produced by<\/td><td>Seamless Bio GmbH (Switzerland) \/ SeamlessBio GmbH (Germany)<\/td><\/tr>\n      <\/table>\n    <\/div>\n  <\/div>\n\n  <!-- FAQ -->\n  <div class=\"sb-nc-section sb-nc-section-alt\">\n    <h2>Frequently Asked Questions<\/h2>\n    <div class=\"sb-nc-faqs\">\n\n      <div class=\"sb-nc-faq\">\n        <h3>What cell lines is NaivaCore compatible with?<\/h3>\n        <p>NaivaCore has been developed based on protocols validated across multiple hESC and iPSC lines. Compatibility across different genetic backgrounds should be confirmed by the user, as naive reprogramming efficiency can vary between lines.<\/p>\n      <\/div>\n\n      <div class=\"sb-nc-faq\">\n        <h3>Can I adjust the inhibitor concentrations in NaivaCore-SI?<\/h3>\n        <p>Yes \u2014 this is a key advantage of the three-component format. Because NaivaCore-SI is supplied separately as a 100\u00d7 concentrate, you can add it at varying dilutions to titrate individual pathway inhibition. This is not possible with single-formulation naive media.<\/p>\n      <\/div>\n\n      <div class=\"sb-nc-faq\">\n        <h3>What feeder system is recommended?<\/h3>\n        <p>NaivaCore supports both feeder-free (Matrigel \/ Geltrex-coated plates) and MEF feeder-dependent culture. Geltrex Flex is included in NaivaCore-SI to support feeder-free naive colony attachment.<\/p>\n      <\/div>\n\n      <div class=\"sb-nc-faq\">\n        <h3>How does NaivaCore compare to t2iLG\u00f6 or PXGL medium?<\/h3>\n        <p>NaivaCore is based on the HENSM formulation which extends t2iLG\u00f6 by adding SRC inhibition (CGP77675), which has been shown to improve naive maintenance stability. Unlike t2iLG\u00f6 (which must be self-prepared from individual components), NaivaCore is available as a ready-to-use kit with consistent quality documentation.<\/p>\n      <\/div>\n\n      <div class=\"sb-nc-faq\">\n        <h3>Is batch reservation available?<\/h3>\n        <p>Yes \u2014 SeamlessBio offers batch reservation at no prepayment. Contact info@seamlessbio.de to reserve a specific production lot for long-term experimental consistency.<\/p>\n      <\/div>\n\n      <div class=\"sb-nc-faq\">\n        <h3>Is NaivaCore available for ATMP or GMP applications?<\/h3>\n        <p>NaivaCore is currently supplied for research use only. A GMP-compatible production pathway is under development. If you have ATMP development needs, contact us to discuss timeline, documentation requirements, and GMP transition planning.<\/p>\n      <\/div>\n\n    <\/div>\n  <\/div>\n\n  <!-- INTERNAL LINKS -->\n  <div class=\"sb-nc-section\">\n    <h2>Related Products<\/h2>\n    <div class=\"sb-nc-related\">\n      <a href=\"https:\/\/www.seamlessbio.de\/applications\/ipsc-stem-cell-culture\/\" class=\"sb-nc-rel-card\">\n        <h3>iPSC &amp; Stem Cell Culture<\/h3>\n        <p>Application guide: FBS, Human Serum AB and media components for iPSC expansion and primed PSC protocols.<\/p>\n      <\/a>\n      <a href=\"https:\/\/www.seamlessbio.de\/products\/albumin-proteins\/bsa-low-endotoxin\/\" class=\"sb-nc-rel-card\">\n        <h3>BSA Low Endotoxin<\/h3>\n        <p>IgG-free, low-endotoxin BSA \u2014 suitable for use in defined stem cell media formulations requiring a carrier protein.<\/p>\n      <\/a>\n      <a href=\"https:\/\/www.seamlessbio.de\/products\/albumin-proteins\/human-serum-albumin-hsa\/\" class=\"sb-nc-rel-card\">\n        <h3>Human Serum Albumin (HSA)<\/h3>\n        <p>Pharmaceutical-grade HSA for xeno-free stem cell applications and serum-free media supplementation.<\/p>\n      <\/a>\n      <a href=\"https:\/\/www.seamlessbio.de\/applications\/cell-therapy-atmps\/\" class=\"sb-nc-rel-card\">\n        <h3>Cell Therapy &amp; ATMP Manufacturing<\/h3>\n        <p>Biologicals and media components for ATMP development pipelines \u2014 from iPSC to final product.<\/p>\n      <\/a>\n    <\/div>\n  <\/div>\n\n  <!-- CTA -->\n  <div class=\"sb-nc-cta\">\n    <h2>Request NaivaCore \u2014 Sample or Quote<\/h2>\n    <p>Available in flexible batch sizes. EU documentation included. Batch reservation possible.<\/p>\n    <div class=\"sb-nc-cta-btns\">\n      <a href=\"https:\/\/www.seamlessbio.de\/about-us\/contact-imprint\/\" class=\"sb-nc-btn\">Contact Us<\/a>\n      <a href=\"mailto:info@seamlessbio.de\" class=\"sb-nc-btn-outline\">info@seamlessbio.de<\/a>\n    <\/div>\n    <p class=\"sb-nc-ruo\">For research use only. Not for diagnostic or therapeutic use.<\/p>\n  <\/div>\n\n<\/div>\n<\/section>\n\n<style>\n\/* ============================================================\n   NaivaCore Product Page \u2014 SeamlessBio Teal Design System\n   Teal: #18b7b2 | Hover: #139b97\n   Gradient: linear-gradient(135deg,#18b7b2 0%,#65d3cf 52%,#e9fbfa 100%)\n   ============================================================ *\/\n\n.sb-nc-page, .sb-nc-page *, .sb-nc-page *::before, .sb-nc-page *::after {\n  box-sizing: border-box;\n}\n\n.sb-nc-page {\n  font-family: Arial, sans-serif;\n  color: #1a1a1a;\n  background: #fff;\n  padding: 60px 32px 90px;\n}\n\n.sb-nc-container {\n  max-width: 1200px;\n  margin: 0 auto;\n}\n\n\/* BREADCRUMB *\/\n.sb-nc-breadcrumb {\n  display: flex;\n  flex-wrap: wrap;\n  gap: 6px;\n  align-items: center;\n  font-size: 13px;\n  color: #888;\n  margin-bottom: 28px;\n}\n.sb-nc-breadcrumb a { color: #18b7b2 !important; text-decoration: none !important; font-weight: 600; }\n.sb-nc-breadcrumb strong { color: #111; 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