{"id":2133,"date":"2026-06-28T21:02:55","date_gmt":"2026-06-28T20:02:55","guid":{"rendered":"http:\/\/seamlessbio.de\/?page_id=2133"},"modified":"2026-07-02T22:14:00","modified_gmt":"2026-07-02T21:14:00","slug":"serum-processing","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/serum-processing\/","title":{"rendered":"Aufbereitung von Service-Serum"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2133\" class=\"elementor elementor-2133\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce7864 e-con e-atomic-element e-flexbox-base e-a596b40 \" data-id=\"9ce7864\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"9ce7864\" data-e-type=\"e-flexbox\" data-id=\"9ce7864\">\n    \t\t<div class=\"elementor-element elementor-element-0d364bb elementor-widget elementor-widget-html\" data-id=\"0d364bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!--\nYOAST SEO \u00b7 Slug: \/services\/serum-processing\/\nSEO Title: Serum Processing Services | Heat Inactivation \u00b7 Gamma Irradiation | SeamlessBio\nMeta Desc: Custom serum processing in Germany \u2014 heat inactivation, charcoal absorption, gamma irradiation 25\u201345 kGy, delipidation, ultra-low IgG, dialysis and virus safety testing. SeamlessBio Passau.\n-->\n<script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\": \"ListItem\", \"position\": 1, \"name\": \"Home\", \"item\": \"https:\/\/www.seamlessbio.de\/\"}, {\"@type\": \"ListItem\", \"position\": 2, \"name\": \"Services\", \"item\": \"https:\/\/www.seamlessbio.de\/services\/\"}]},{\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\": \"Question\", \"name\": \"What serum processing services does SeamlessBio offer?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Seven processing types: heat inactivation (56\\u00b0C\/30 min), charcoal absorption (single or double), gamma irradiation (25\\u201345 kGy at a validated ISO 11137-compliant external facility), delipidation, ultra-low IgG depletion, dialysis (3.5\\u201350 kDa MWCO) and external virus safety testing to pharmaceutical standards. All processing at our Passau, Germany facility except gamma irradiation.\"}}, {\"@type\": \"Question\", \"name\": \"Can processing be applied to customer-supplied serum?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Yes \\u2014 all seven processing services are available for customer-supplied serum lots as well as SeamlessBio stock. Submit your serum type, volume and required treatment for lead time and pricing.\"}}, {\"@type\": \"Question\", \"name\": \"What documentation is provided for gamma irradiated serum?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Full irradiation certificate, dose report (dose range specified per order), facility validation documentation and CoA post-irradiation. Gamma irradiation at validated ISO 11137-compliant external contract irradiation facility.\"}}]}]}<\/script>\n<div class=\"sbp-page\"><div class=\"sbp-wrap\">\n<nav class=\"sbp-bc\"><a href=\"https:\/\/www.seamlessbio.de\/\">Home<\/a><span>\/<\/span><a href=\"https:\/\/www.seamlessbio.de\/services\/\">Services<\/a><span>\/<\/span><strong>Serum Processing<\/strong><\/nav>\n<div class=\"sbp-hero\">\n  <span class=\"sbp-eyebrow\">Processed in Germany \u00b7 7 Processing Types \u00b7 FBS & Human Serum \u00b7 Custom Lots<\/span>\n  <h1>Serum Processing Services<\/h1>\n  <p>Custom serum and biological fluid processing at our Passau, Germany facility \u2014 seven treatment types for FBS, human serum, animal sera and other biological materials. Applied to SeamlessBio stock or customer-supplied lots. Full documentation with every processed batch.<\/p>\n  <div class=\"sbp-tags\"><span>Heat Inactivation<\/span><span>Gamma Irradiation 25\u201345 kGy<\/span><span>Charcoal Absorption<\/span><span>Delipidation<\/span><span>Ultra-Low IgG<\/span><span>Dialysis<\/span><span>Processed in Germany<\/span><\/div>\n  <div class=\"sbp-btns\">\n    <a href=\"mailto:info@seamlessbio.de?subject=Serum%20Processing%20Enquiry\" class=\"sbp-btn\">Request Processing Quote<\/a>\n    <a href=\"https:\/\/www.seamlessbio.de\/about-us\/contact-imprint\/\" class=\"sbp-btn-o\">Contact Us<\/a>\n  <\/div>\n<\/div>\n\n<div class=\"sbp-section\">\n<h2 class=\"sbp-h2\">7 Processing Services<\/h2>\n<div class=\"sbp-grid-3\">\n<div class=\"sbp-card\"><h3>Heat Inactivation<\/h3><p><strong>56\u00b0C for 30 minutes.<\/strong> Destroys complement proteins \u2014 standard for hybridoma culture, hematopoietic cell applications and immunoassays where complement activity causes interference. Does not significantly affect growth factor content.<\/p><\/div>\n<div class=\"sbp-card\"><h3>Charcoal Absorption<\/h3><p><strong>Single or double treatment.<\/strong> Removes lipophilic molecules including steroids, hormones and lipids. Single charcoal for lipid reduction; double charcoal for near-zero steroid depletion. Standard for steroid receptor assay calibrators.<\/p><\/div>\n<div class=\"sbp-card\"><h3>Gamma Irradiation<\/h3><p><strong>25\u201345 kGy.<\/strong> Virus safety treatment at validated ISO 11137-compliant external facility. Full irradiation certificate and dose report per lot. FDA\/EMA accepted for GMP pathway FBS. Highest virus safety documentation available.<\/p><\/div>\n<div class=\"sbp-card\"><h3>Delipidation<\/h3><p><strong>Lipid removal, hormones retained.<\/strong> For CLSI EP7 lipemia interference studies and IVD calibrator matrices where lipid is the interference variable. Differs from charcoal treatment \u2014 steroid hormones remain intact.<\/p><\/div>\n<div class=\"sbp-card\"><h3>Ultra-Low IgG Depletion<\/h3><p><strong>IgG reduced to &lt;50 \u00b5g\/mL.<\/strong> Protein A\/G affinity depletion of IgG from serum. Required for ELISA and western blot applications where bovine or human IgG cross-reacts with detection antibodies.<\/p><\/div>\n<div class=\"sbp-card\"><h3>Dialysis<\/h3><p><strong>3.5\u201350 kDa MWCO.<\/strong> Removal of small molecules \u2014 growth factors, hormones, amino acids \u2014 to produce defined, low-molecular-weight depleted serum for specific research applications.<\/p><\/div>\n<\/div>\n<div class=\"sbp-card\" style=\"margin-top:20px;border-color:#18b7b2\">\n<h3>External Virus Safety Testing<\/h3>\n<p>Pharmaceutical-standard virus safety testing for FBS, human serum and other biological materials \u2014 viral marker panel including PCR-based virus detection. Testing at accredited external laboratory. Report suitable for regulatory submission and ATMP ancillary material files.<\/p>\n<\/div>\n<\/div>\n\n<div class=\"sbp-alt\">\n<h2 class=\"sbp-h2\">Processing at a Glance<\/h2>\n<table class=\"sbp-table\">\n<tr><th>Service<\/th><th>Target<\/th><th>Key Application<\/th><th>Documentation<\/th><\/tr>\n<tr><td>Heat Inactivation<\/td><td>Complement proteins<\/td><td>Hybridoma, hematopoietic cells, immunoassay matrix<\/td><td>CoA, processing record<\/td><\/tr>\n<tr><td>Charcoal \u2014 Single<\/td><td>Lipids, some steroids<\/td><td>Lipid-depleted serum for general research use<\/td><td>CoA, processing record<\/td><\/tr>\n<tr><td>Charcoal \u2014 Double<\/td><td>Steroids to near-zero<\/td><td>Steroid immunoassay calibrators, ER\/PR\/AR cell culture<\/td><td>CoA, steroid depletion data<\/td><\/tr>\n<tr><td>Gamma Irradiation 25 kGy<\/td><td>Viruses<\/td><td>GMP-pathway FBS minimum dose<\/td><td>Irradiation certificate, dose report<\/td><\/tr>\n<tr><td>Gamma Irradiation 45 kGy<\/td><td>Viruses (maximum dose)<\/td><td>Highest virus safety documentation<\/td><td>Irradiation certificate, dose report<\/td><\/tr>\n<tr><td>Delipidation<\/td><td>Lipids only<\/td><td>CLSI EP7 lipemia baseline, IVD calibrator matrix<\/td><td>CoA, lipid depletion data<\/td><\/tr>\n<tr><td>Ultra-Low IgG<\/td><td>IgG to &lt;50 \u00b5g\/mL<\/td><td>Immunoassay, ELISA, western blot with bovine anti-IgG<\/td><td>CoA, IgG concentration data<\/td><\/tr>\n<tr><td>Dialysis 3.5 kDa<\/td><td>Small molecules, hormones<\/td><td>Defined serum for growth factor research<\/td><td>CoA, processing record<\/td><\/tr>\n<tr><td>Virus Safety Testing<\/td><td>Viral contaminants<\/td><td>ATMP ancillary material file, regulatory submission<\/td><td>Testing report, accreditation<\/td><\/tr>\n<\/table>\n<\/div>\n\n<div class=\"sbp-section\">\n<h2 class=\"sbp-h2\">Can We Process Your Own Serum?<\/h2>\n<div class=\"sbp-grid-2\">\n<div class=\"sbp-card\"><h3>Customer-Supplied Serum Processing<\/h3><p>All seven processing services are available for customer-supplied serum or biological fluid lots \u2014 not just SeamlessBio stock. Submit your serum type, volume, required treatment and any specification requirements for a processing quote and lead time. Minimum volumes apply per treatment type.<\/p><\/div>\n<div class=\"sbp-card\"><h3>Minimum Volumes<\/h3><p>Heat inactivation: from 50 mL. Charcoal absorption: from 100 mL. Gamma irradiation: minimum volumes depend on irradiation facility requirements \u2014 typically from 500 mL. Delipidation, IgG depletion, dialysis: from 100 mL. Contact us with your volume for exact minimums.<\/p><\/div>\n<\/div>\n<\/div>\n\n<div class=\"sbp-section\">\n<h2 class=\"sbp-h2\">Frequently Asked Questions<\/h2>\n<div class=\"sbp-faq\"><h3>What serum processing services are available?<\/h3><p>Seven processing types: heat inactivation (56\u00b0C\/30 min), single and double charcoal absorption, gamma irradiation (25\u201345 kGy), delipidation, ultra-low IgG depletion, dialysis (3.5\u201350 kDa) and external virus safety testing. All at our Germany facility except gamma irradiation (external ISO 11137 facility).<\/p><\/div>\n<div class=\"sbp-faq\"><h3>Can processing be applied to my own serum lot?<\/h3><p>Yes \u2014 all services available for customer-supplied lots as well as SeamlessBio stock. Contact us with serum type, volume and required treatment for pricing and lead time.<\/p><\/div>\n<div class=\"sbp-faq\"><h3>What is the difference between charcoal and delipidation?<\/h3><p>Charcoal absorption removes both lipids AND steroid hormones \u2014 steroid hormones adsorb to the charcoal along with lipids. Delipidation removes lipids only \u2014 steroid hormones remain in the serum. Use charcoal for steroid assay calibrators; use delipidation for CLSI EP7 lipemia studies where hormones must be retained.<\/p><\/div>\n<div class=\"sbp-faq\"><h3>What documentation is provided for gamma irradiated serum?<\/h3><p>Full irradiation certificate, dose report (minimum\/maximum dose specified per order), facility validation documentation and CoA post-irradiation. Suitable for FDA\/EMA regulatory submissions and GMP batch records.<\/p><\/div>\n<\/div>\n\n<div class=\"sbp-cta\"><h2>Request Serum Processing Quote<\/h2><p>Tell us your serum type, volume, required treatment and application. We respond within 48 hours with pricing and lead time.<\/p><div class=\"sbp-cta-btns\"><a href=\"mailto:info@seamlessbio.de?subject=Serum%20Processing%20Quote\" class=\"sbp-btn\">Request Quote<\/a><a href=\"https:\/\/www.seamlessbio.de\/about-us\/contact-imprint\/\" class=\"sbp-btn-o\">Contact Us<\/a><\/div><\/div>\n<\/div><\/div>\n<style>\n.sbp-page,.sbp-page *{box-sizing:border-box}\n.sbp-page{font-family:Arial,sans-serif;color:#202020;background:#fff;padding:60px 0 90px}\n.sbp-wrap{max-width:1400px;margin:0 auto;padding:0 40px}\n.sbp-bc{display:flex;flex-wrap:wrap;gap:6px;align-items:center;font-size:13px;color:#999;margin-bottom:32px}\n.sbp-bc a{color:#18b7b2!important;text-decoration:none!important;font-weight:600}.sbp-bc span{color:#ddd}\n.sbp-hero{background:#f7fbfb;border:1px solid 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Germany [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_eb_attr":"","footnotes":""},"class_list":["post-2133","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Serum Processing Services | Heat Inactivation \u00b7 Gamma Irradiation<\/title>\n<meta name=\"description\" content=\"Custom serum processing in Germany \u2014 heat inactivation, charcoal absorption, gamma irradiation 25\u201345 kGy, delipidation, ultra-low IgG, dialysis and virus safety testing\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/seamlessbio.de\/de\/serum-processing\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" 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