{"id":2402,"date":"2026-07-10T14:17:31","date_gmt":"2026-07-10T13:17:31","guid":{"rendered":"https:\/\/seamlessbio.de\/?page_id=2402"},"modified":"2026-07-12T14:55:33","modified_gmt":"2026-07-12T13:55:33","slug":"humanplasma-von-einem-einzigen-spender","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/human-plasma-single-donor\/","title":{"rendered":"Humanplasma von einem einzigen Spender"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2402\" class=\"elementor elementor-2402\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a9bd7f8 e-con e-atomic-element e-flexbox-base e-6965ff0 \" data-id=\"a9bd7f8\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"a9bd7f8\" data-e-type=\"e-flexbox\" data-id=\"a9bd7f8\">\n    \t\t<div class=\"elementor-element elementor-element-77281ef elementor-widget elementor-widget-html\" data-id=\"77281ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- ============================================================\n  SEAMLESSBIO WORDPRESS \u2014 ELEMENTOR HTML WIDGET\n  Design: sb-pp (Referenz Human Serum Single-Use Bags)\n  PAGE: Human Plasma \u2014 Single Donor\n  URL SLUG: \/human-plasma-single-donor\/\n\n  YOAST SEO:\n  SEO Title:       Human Plasma Single Donor | EU Origin | Traceable | SeamlessBio\n  Slug:            human-plasma-single-donor\n  Focus Keyword:   human plasma single donor supplier\n  Meta Description: Single-donor human plasma from certified EU blood banks \u2014 full donor traceability, per-unit viral screening, EDTA, heparin or citrate. For reference panels, disease-state models and IVD validation. No minimum order. 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1fr}.sb-pp-twocol{grid-template-columns:1fr;gap:32px}}\n@media(max-width:600px){.sb-pp{padding:20px 16px 60px}.sb-pp-hero h1{font-size:28px}.sb-pp-hero-btns{flex-direction:column}.sb-pp-usps{grid-template-columns:1fr}.sb-pp-qs-grid{grid-template-columns:1fr}.sb-pp-cta{padding:32px 20px}.sb-pp-cta-btns{flex-direction:column}}\n<\/style>\n\n<div class=\"sb-pp\">\n\n<!-- BREADCRUMB -->\n<nav class=\"sb-pp-bc\">\n  <a href=\"https:\/\/seamlessbio.de\/\">Home<\/a> <span>\/<\/span>\n  <a href=\"https:\/\/seamlessbio.de\/human-sera-plasma-and-more\/\">Human Sera &amp; Plasma<\/a> <span>\/<\/span>\n  <a href=\"https:\/\/seamlessbio.de\/human-plasma-apheresis-plasma\/\">Human Plasma<\/a> <span>\/<\/span>\n  Single Donor Plasma\n<\/nav>\n\n<!-- HERO -->\n<div class=\"sb-pp-hero\">\n  <div class=\"sb-pp-hero-left\">\n    <div class=\"sb-pp-hero-eyebrow\">Per-Unit Viral Screening \u00b7 Full Donor Traceability \u00b7 EU Origin \u00b7 EDTA \u00b7 Heparin \u00b7 Citrate<\/div>\n    <h1>Human Plasma \u2014 Single Donor<\/h1>\n    <p class=\"sb-pp-hero-desc\">Single-donor human plasma from certified EU blood banks \u2014 individually screened, fully traceable to the donor unit. For disease-state research, reference panels, IVD validation and applications where pooled plasma introduces unacceptable variability. EDTA, heparin or citrate. No minimum order.<\/p>\n    <div class=\"sb-pp-hero-btns\">\n      <a href=\"mailto:info@seamlessbio.de?subject=Human%20Plasma%20Single%20Donor%20Enquiry\" class=\"sb-pp-btn-dark\">Request Specifications<\/a>\n      <a href=\"https:\/\/seamlessbio.de\/human-plasma-apheresis-plasma\/\" class=\"sb-pp-btn-outline\">All Plasma Products<\/a>\n    <\/div>\n  <\/div>\n<\/div>\n\n<!-- USP CARDS -->\n<div class=\"sb-pp-usps\">\n  <div class=\"sb-pp-usp\">\n    <div class=\"sb-pp-usp-num\">01<\/div>\n    <h3>Full Donor Traceability<\/h3>\n    <p>Every unit traceable to individual donor. Donation ID, collection date, blood group, age range and gender documented per unit.<\/p>\n  <\/div>\n  <div class=\"sb-pp-usp\">\n    <div class=\"sb-pp-usp-num\">02<\/div>\n    <h3>Per-Unit Viral Screening<\/h3>\n    <p>HIV-1\/2, HBsAg, anti-HCV, syphilis tested per individual unit \u2014 not per pool. NAT screening (HIV-1, HCV, HBV) available on request.<\/p>\n  <\/div>\n  <div class=\"sb-pp-usp\">\n    <div class=\"sb-pp-usp-num\">03<\/div>\n    <h3>Disease-State on Request<\/h3>\n    <p>Plasma from donors with defined disease states \u2014 sepsis, DKA, COVID-19, COPD, liver disease and more \u2014 available on request via our donor network.<\/p>\n  <\/div>\n  <div class=\"sb-pp-usp\">\n    <div class=\"sb-pp-usp-num\">04<\/div>\n    <h3>No Minimum Order<\/h3>\n    <p>From single units for feasibility to large cohort panels. Same documentation and traceability at every scale.<\/p>\n  <\/div>\n<\/div>\n\n<!-- QUICK SELECTION -->\n<div class=\"sb-pp-qs\">\n  <h2>Single Donor vs. Pooled \u2014 which do you need?<\/h2>\n  <div class=\"sb-pp-qs-grid\">\n    <a class=\"sb-pp-qs-card\" href=\"\/human-plasma-single-donor\/\">\n      <div class=\"sb-pp-qs-card-label\">Individual traceability \u00b7 Disease-state \u00b7 Reference panels<\/div>\n      <div class=\"sb-pp-qs-card-link\">Single Donor Plasma \u2192 (this page)<\/div>\n    <\/a>\n    <a class=\"sb-pp-qs-card\" href=\"https:\/\/seamlessbio.de\/human-plasma-pooled\/\">\n      <div class=\"sb-pp-qs-card-label\">Reduced variability \u00b7 IVD calibrators \u00b7 High volume<\/div>\n      <div class=\"sb-pp-qs-card-link\">Pooled Plasma \u2192<\/div>\n    <\/a>\n    <a class=\"sb-pp-qs-card\" href=\"https:\/\/seamlessbio.de\/human-plasma-type-ab-male\/\">\n      <div class=\"sb-pp-qs-card-label\">No anti-A\/B \u00b7 Male donors \u00b7 CAR-T & ATMP<\/div>\n      <div class=\"sb-pp-qs-card-link\">Plasma Type AB Male \u2192<\/div>\n    <\/a>\n    <a class=\"sb-pp-qs-card\" href=\"https:\/\/seamlessbio.de\/human-serum\/\">\n      <div class=\"sb-pp-qs-card-label\">No fibrinogen \u00b7 Off-the-Clot variants available<\/div>\n      <div class=\"sb-pp-qs-card-link\">Human Serum \u2192<\/div>\n    <\/a>\n    <a class=\"sb-pp-qs-card\" href=\"https:\/\/seamlessbio.de\/autoimmune-control-sera\/\">\n      <div class=\"sb-pp-qs-card-label\">ANA \u00b7 RF \u00b7 ANCA \u00b7 disease-characterised<\/div>\n      <div class=\"sb-pp-qs-card-link\">Autoimmune Control Sera \u2192<\/div>\n    <\/a>\n    <a class=\"sb-pp-qs-card\" href=\"mailto:info@seamlessbio.de\">\n      <div class=\"sb-pp-qs-card-label\">Custom cohort, specific disease state or donor profile<\/div>\n      <div class=\"sb-pp-qs-card-link\">Custom Request \u2192<\/div>\n    <\/a>\n  <\/div>\n<\/div>\n\n<hr class=\"sb-pp-divider\">\n\n<!-- ANTICOAGULANT TABLE -->\n<div class=\"sb-pp-qs\">\n  <h2>Available Anticoagulant Formats<\/h2>\n  <div class=\"sb-pp-table-wrap\">\n  <table class=\"sb-pp-table\">\n    <thead>\n      <tr><th>Anticoagulant<\/th><th>Mechanism<\/th><th>Best For<\/th><th>Cell Culture Note<\/th><\/tr>\n    <\/thead>\n    <tbody>\n      <tr>\n        <td>EDTA (K2\/K3)<\/td>\n        <td>Irreversible Ca\u00b2\u207a\/Mg\u00b2\u207a chelation<\/td>\n        <td>Haematology, immunoassay, general IVD, proteomics<\/td>\n        <td>Can be overcome by media cations at high plasma % \u2014 use with caution at \u226520% v\/v<\/td>\n      <\/tr>\n      <tr>\n        <td>Heparin (Li\/Na)<\/td>\n        <td>Thrombin inhibition \u2014 media-independent<\/td>\n        <td>Cell culture stimulus models, translational disease research, endothelial assays<\/td>\n        <td>Preferred for cell culture at \u226520% v\/v \u2014 anticoagulation maintained independently of media composition. Min. 0.25 IU\/mL.<\/td>\n      <\/tr>\n      <tr>\n        <td>Citrate (3.2%)<\/td>\n        <td>Reversible Ca\u00b2\u207a chelation<\/td>\n        <td>Coagulation studies, platelet function, PRP preparation<\/td>\n        <td>Coagulation risk at high % v\/v in cell culture \u2014 use at low concentrations or where coagulation factors are the study target<\/td>\n      <\/tr>\n      <tr>\n        <td>ACD-A<\/td>\n        <td>Citrate + dextrose<\/td>\n        <td>PBMC isolation, platelet preparation, cell therapy<\/td>\n        <td>Standard for leukapheresis-compatible processing. Not for routine clinical chemistry.<\/td>\n      <\/tr>\n    <\/tbody>\n  <\/table>\n  <\/div>\n  <p style=\"font-size:13px;color:#888;margin:14px 0 0\">Anticoagulant must be specified at order \u2014 results are not comparable across formats. See our <a href=\"https:\/\/seamlessbio.de\/blog\/human-plasma-serum-cell-culture-stimulus\/\" style=\"color:#18b7b2\">methodological guide on plasma in cell culture<\/a> for anticoagulant selection guidance.<\/p>\n<\/div>\n\n<hr class=\"sb-pp-divider\">\n\n<!-- TWO COL -->\n<div class=\"sb-pp-twocol\">\n  <div>\n    <h2>Why single-donor plasma \u2014 and when does it matter?<\/h2>\n    <p>Pooled plasma from multiple donors averages out individual variability \u2014 which is exactly what you want for IVD calibrators and assay controls where lot-to-lot consistency is the priority. But for disease-state research, reference panel development and studies examining inter-individual biological differences, pooling destroys the very signal you are trying to measure.<\/p>\n    <p>Single-donor plasma preserves the biological signature of each individual unit. The donor's disease status, age, sex, medication history and metabolic state are all reflected in the plasma proteome, cytokine profile and coagulation factor composition. This is the format used in the translational disease models described by Cela et al. (2025, PMC11864229) and across the sepsis, COVID-19, DKA and COPD literature.<\/p>\n    <p>SeamlessBio supplies single-donor plasma with full donor traceability and per-unit viral screening \u2014 the documentation standard required for use in IVD technical files and translational research publications.<\/p>\n  <\/div>\n  <div>\n    <h3>Key applications<\/h3>\n    <ul class=\"sb-pp-bullets\">\n      <li>Disease-state cell culture stimulus \u2014 sepsis, COVID-19, DKA, COPD, liver disease<\/li>\n      <li>Reference panel development for IVD assay validation<\/li>\n      <li>Inter-individual variability studies \u2014 age, sex, BMI, medication effects<\/li>\n      <li>Pharmacokinetic and drug-protein binding studies<\/li>\n      <li>Translational research \u2014 bridging in vitro findings to clinical data<\/li>\n      <li>Biomarker discovery \u2014 individual donor proteomics and metabolomics<\/li>\n      <li>Residual disease monitoring \u2014 longitudinal sample series from same donor<\/li>\n      <li>Positive control panels for infectious disease IVD assays<\/li>\n      <li>NAT and serology panel development<\/li>\n      <li>Specificity and cross-reactivity testing with defined donor characteristics<\/li>\n    <\/ul>\n  <\/div>\n<\/div>\n\n<hr class=\"sb-pp-divider\">\n\n<!-- SPECS TABLE -->\n<div class=\"sb-pp-specs\">\n  <h2>Product Specifications<\/h2>\n  <div class=\"sb-pp-table-wrap\">\n  <table class=\"sb-pp-table\">\n    <tbody>\n      <tr><td>Product type<\/td><td>Human Plasma \u2014 Single Donor, individually screened<\/td><\/tr>\n      <tr><td>Origin<\/td><td>EU certified blood banks (Germany, Austria, Czech Republic, Poland)<\/td><\/tr>\n      <tr><td>Donor traceability<\/td><td>Full \u2014 donation ID, collection date, blood group, age range, gender per unit<\/td><\/tr>\n      <tr><td>Viral screening<\/td><td>Per unit: HIV-1\/2, HBsAg, anti-HCV, Syphilis. NAT (HIV-1 RNA, HCV RNA, HBV DNA) on request<\/td><\/tr>\n      <tr><td>Anticoagulants<\/td><td>EDTA (K2\/K3) \u00b7 Heparin (Li\/Na) \u00b7 Sodium Citrate 3.2% \u00b7 ACD-A \u2014 specify at order<\/td><\/tr>\n      <tr><td>Blood group<\/td><td>Mixed (standard) \u00b7 A \u00b7 B \u00b7 AB \u00b7 O \u2014 specify on request<\/td><\/tr>\n      <tr><td>Donor gender<\/td><td>Mixed (standard) \u00b7 Male only \u00b7 Female only \u2014 specify on request<\/td><\/tr>\n      <tr><td>Donor age range<\/td><td>18\u201365 years (standard) \u00b7 Narrower ranges on request<\/td><\/tr>\n      <tr><td>Disease-state plasma<\/td><td>Available on request \u2014 contact info@seamlessbio.de with indication<\/td><\/tr>\n      <tr><td>Volume per unit<\/td><td>Typically 5\u201310 mL per donor unit \u00b7 Larger volumes via apheresis on request<\/td><\/tr>\n      <tr><td>Pack formats<\/td><td>Individual units \u00b7 Matched cohort sets \u00b7 Custom panel configurations<\/td><\/tr>\n      <tr><td>Storage<\/td><td>\u221220\u00b0C (standard) \u00b7 \u221280\u00b0C for long-term storage on request<\/td><\/tr>\n      <tr><td>Shelf life<\/td><td>24 months from collection date at \u221220\u00b0C<\/td><\/tr>\n      <tr><td>Documentation<\/td><td>CoA \u00b7 CoO \u00b7 per-unit donor record \u00b7 viral screening report \u00b7 SDS<\/td><\/tr>\n      <tr><td>Minimum order<\/td><td>No minimum order quantity<\/td><\/tr>\n      <tr><td>Lead time<\/td><td>Standard: 5\u201310 business days \u00b7 Disease-state \/ custom cohort: on request<\/td><\/tr>\n    <\/tbody>\n  <\/table>\n  <\/div>\n<\/div>\n\n<hr class=\"sb-pp-divider\">\n\n<!-- FAQ -->\n<div class=\"sb-pp-faq\">\n  <h2>Frequently Asked Questions<\/h2>\n\n  <div class=\"sb-pp-faq-item\">\n    <h3>What is the difference between single-donor and pooled plasma?<\/h3>\n    <p>Single-donor plasma comes from one individual unit with full traceability \u2014 donor ID, blood group, age, sex and viral screening per unit. Pooled plasma combines material from multiple donors, averaging out individual variability. Single-donor is required for disease-state research, inter-individual studies and reference panels. Pooled is preferred for IVD calibrators and assay controls where consistency across large volumes is the priority.<\/p>\n  <\/div>\n\n  <div class=\"sb-pp-faq-item\">\n    <h3>Which anticoagulant should I use for cell culture experiments?<\/h3>\n    <p>Heparin plasma is the recommended choice for cell culture experiments using plasma as a stimulus at \u226520% v\/v. Heparin inhibits thrombin independently of the culture medium composition \u2014 EDTA and citrate anticoagulation can be overcome by divalent cations in standard media. Minimum 0.25 IU\/mL heparin to prevent coagulation while minimising off-target effects on cell adhesion and signalling.<\/p>\n  <\/div>\n\n  <div class=\"sb-pp-faq-item\">\n    <h3>Can I order disease-state plasma from specific patient populations?<\/h3>\n    <p>Yes. SeamlessBio can source plasma from donors with defined disease states via our EU donor network. Common requests include sepsis, COVID-19 (acute and convalescent), COPD, diabetic ketoacidosis, liver disease (NAFLD, ESLD, HCV) and autoimmune conditions. Contact info@seamlessbio.de with your required disease indication, donor characteristics and volume \u2014 we confirm availability and lead time.<\/p>\n  <\/div>\n\n  <div class=\"sb-pp-faq-item\">\n    <h3>Can I specify donor characteristics such as blood group, age or sex?<\/h3>\n    <p>Yes. Blood group (A, B, AB, O), donor sex (male, female) and age range can be specified. Matching donors by age and sex is recommended for disease-state experiments to reduce confounding variables \u2014 documented in the translational research literature as a critical methodological consideration (Cela et al., 2025).<\/p>\n  <\/div>\n\n  <div class=\"sb-pp-faq-item\">\n    <h3>Is NAT screening available?<\/h3>\n    <p>Yes \u2014 NAT (nucleic acid amplification testing) for HIV-1 RNA, HCV RNA and HBV DNA is available on request. Standard viral screening covers serology per unit (HIV-1\/2, HBsAg, anti-HCV, Syphilis). For IVD validation requiring NAT-screened material, specify at order.<\/p>\n  <\/div>\n\n  <div class=\"sb-pp-faq-item\">\n    <h3>Can I get longitudinal samples from the same donor?<\/h3>\n    <p>Longitudinal sample series (multiple time points from the same donor) are available on request for monitoring studies \u2014 residual disease, treatment response, recovery. Contact info@seamlessbio.de with your study design and sampling schedule.<\/p>\n  <\/div>\n<\/div>\n\n<!-- CTA -->\n<div class=\"sb-pp-cta\">\n  <h2>Request Single Donor Plasma<\/h2>\n  <p>Specify anticoagulant, donor characteristics, volume and any disease-state requirements \u2014 we respond within 48 hours. 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Pooled plasma combines material from multiple donors. Single-donor is required for disease-state research, inter-individual studies and reference panels. Pooled suits IVD calibrators where consistency is the priority.\" }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Which anticoagulant should I use for cell culture experiments with plasma?\",\n      \"acceptedAnswer\": { \"@type\": \"Answer\", \"text\": \"Heparin plasma is recommended for cell culture at \u226520% v\/v. Heparin inhibits thrombin independently of media composition \u2014 EDTA and citrate can be overcome by divalent cations in standard culture media. Minimum 0.25 IU\/mL heparin to prevent coagulation while minimising off-target effects.\" }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Can I order disease-state plasma from specific patient populations?\",\n      \"acceptedAnswer\": { \"@type\": \"Answer\", \"text\": \"Yes. 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