{"id":2928,"date":"2026-08-22T15:51:30","date_gmt":"2026-08-22T14:51:30","guid":{"rendered":"https:\/\/wheat-quail-856400.hostingersite.com\/?page_id=2928"},"modified":"2026-11-09T10:32:42","modified_gmt":"2026-11-09T09:32:42","slug":"what-is-rhsa-recombinant-human-serum-albumin","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/what-is-rhsa-recombinant-human-serum-albumin\/","title":{"rendered":"Was ist rHSA (rekombinantes Humanserumalbumin)?"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"2928\" class=\"elementor elementor-2928\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c244718 e-con e-atomic-element e-flexbox-base e-default-div e-40cb766\" data-id=\"c244718\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"c244718\">\n    \t\t<div class=\"elementor-element elementor-element-2a19da1 elementor-widget elementor-widget-html\" data-id=\"2a19da1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- \nWORDPRESS PAGE \u2014 PASTE INTO GUTENBERG \"BENUTZERDEFINIERTES HTML\" BLOCK\nYoast SEO:\n  Slug: what-is-rhsa-recombinant-human-serum-albumin\n  SEO Title: What is rHSA (Recombinant Human Serum Albumin)? | SeamlessBio\n  Meta Description: What is recombinant human serum albumin (rHSA), how is it produced, what does it do in serum-free cell culture, and when should you use it instead of BSA?\n  Focus Keyword: what is rHSA recombinant human serum albumin\n  Meta Robots: index, follow\n  Page Type: Article\n-->\n\n<div style=\"background:#e9fbfa;border-left:4px solid #18b7b2;border-radius:0 8px 8px 0;padding:20px 24px;margin-bottom:32px;\">\n<p style=\"font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:1px;color:#139b97;margin-bottom:8px;\">Kurzdefinition<\/p>\n<p style=\"font-size:16px;margin:0;\"><strong>Was ist rHSA (rekombinantes humanes Serumalbumin)?:<\/strong> Rekombinantes humanes Serumalbumin (rHSA) ist humanes Serumalbumin, das durch rekombinante Expression in nicht-tierischen Systemen hergestellt wird \u2013 meist Reis (Oryza sativa) oder Hefe (Pichia pastoris). Seine Aminos\u00e4uresequenz ist identisch mit nativem humanem Serumalbumin, es wird aber ohne menschliche Spender und ohne bovine Quellen hergestellt \u2013 damit ist es tierfrei und xenofrei f\u00fcr GMP-Zellkulturanwendungen.<\/p>\n<!-- BUY BOX (SEO: links to buy pages) -->\n<div class=\"sb-buy-box\" style=\"border:1px solid #cfe9e6;background:#f4fbfa;border-radius:12px;padding:22px 26px;margin:28px auto;max-width:1200px;box-sizing:border-box\">\n<h2 style=\"font-size:22px;line-height:1.3;margin:0 0 6px\">Albumin kaufen \u2013 HSA, rHSA und BSA ab EU-Lager<\/h2>\n<p style=\"margin:0 0 14px\">Angebot oder kostenloses Testmuster anfragen \u2013 EU-Lager, Chargenreservierung bis zu 36 Monate.<\/p>\n<ul style=\"margin:0;padding-left:20px;columns:2 300px;column-gap:32px\">\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/rhsa-premium\/\" style=\"font-weight:700\">rHSA Premium \u2013 rekombinantes HSA<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/rhsa-economy-rekombinantes-humanes-serumalbumin\/\" style=\"font-weight:700\">rHSA Economy \u2013 rekombinantes HSA<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/humanes-serumalbumin-hsa-pulver-96\/\">Humanes Serumalbumin (HSA) \u2013 Pulver \u226596 %<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/humanes-serumalbumin-hsa-5-prozent-loesung\/\">HSA-L\u00f6sung 5 %<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/humanes-serumalbumin-hsa-20-prozent-loesung\/\">HSA-L\u00f6sung 20 %<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/humanes-serumalbumin-hsa-25-prozent-loesung\/\">HSA-L\u00f6sung 25 %<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/bsa-standard-grade-bovines-serumalbumin\/\">BSA Standard Grade \u226596 %<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/bsa-frei-von-fettsauren\/\">BSA Fetts\u00e4urefrei<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/bsa-mit-niedrigem-endotoxingehalt\/\">BSA, endotoxinarm<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/?post_type=product&p=3537\">Rekombinantes humanes Transferrin<\/a><\/li>\n<\/ul>\n<p style=\"margin:14px 0 0\"><a href=\"https:\/\/seamlessbio.de\/de\/request-quote\/\" style=\"font-weight:600\">Angebot anfordern \u2192<\/a><\/p>\n<\/div>\n<!-- \/BUY BOX -->\n\n<\/div>\n\n<!-- SB-BUY-BOX --><div style=\"border:1px solid #daf3f2;border-left:4px solid #18b7b2;background:#f1faf9;border-radius:0 10px 10px 0;padding:14px 18px;margin:18px 0 26px;font-size:15px;line-height:1.6\"><strong>Bereit zu bestellen?<\/strong> <a href=\"https:\/\/seamlessbio.de\/de\/rhsa-uebersicht\/\" style=\"color:#18b7b2;font-weight:700\">Rekombinantes humanes Serumalbumin (rHSA) kaufen \u2192<\/a><br><span style=\"font-size:14px;color:#5b6b71\">Qualit\u00e4ten Economy, Premium und CHO-exprimiert \u00b7 tierfrei \u00b7 EU-Lager \u00b7 gratis Muster<\/span><\/div>\n<h2>Warum rHSA statt BSA?<\/h2>\n<p>Bovines Serumalbumin (BSA) ist in serumfreien Medien als Albuminquelle weit verbreitet, hat aber zwei Nachteile: Es ist tierischen Ursprungs (problematisch f\u00fcr die xenofreie ATMP-Herstellung), und seine Wirkstoffbindungsaffinit\u00e4t unterscheidet sich bei vielen Substanzen von humanem Albumin (relevant f\u00fcr DMPK-Proteinbindungsassays). rHSA l\u00f6st beide Probleme \u2013 tierfreie Herstellung mit den Bindungseigenschaften der humanen Sequenz.<\/p>\n\n<h2>rHSA in der Formulierung serumfreier Medien<\/h2>\n<p>In einem vollst\u00e4ndigen serumfreien FKS-Ersatzmedium \u00fcbernimmt rHSA mit 1\u20135 g\/l die Funktion des Tr\u00e4gerproteins. Es muss mit weiteren FKS-Ersatzkomponenten kombiniert werden: rekombinantes Transferrin (OsrhTF, f\u00fcr den Eisentransport), rekombinantes Insulin (f\u00fcr die Glukoseaufnahme), rekombinantes IGF-1, EGF oder FGF-2 (zelltypspezifische Wachstumsfaktoren) und Selen (Antioxidans). Ohne rHSA lassen sich fettl\u00f6sliche N\u00e4hrstoffe im w\u00e4ssrigen Medium nicht zu den Zellen transportieren.<\/p>\n\n<h2>rHSA-Varianten von SeamlessBio<\/h2>\n<p>SeamlessBio liefert drei rHSA-Qualit\u00e4ten: Economy (kosteng\u00fcnstig f\u00fcr Forschung ohne GMP), Premium (h\u00f6here Reinheit f\u00fcr empfindliche Anwendungen) und CHO-exprimiert (S\u00e4ugerexpressionssystem f\u00fcr besondere Glykosylierungsanforderungen).<\/p>\n\n<h2>Wichtige Fakten<\/h2>\n<ul>\n<li>rHSA hat dieselbe Sequenz wie natives HSA (585 Aminos\u00e4uren, MW ~66,5 kDa) \u2013 mit denselben Wirkstoffbindungsstellen (Site I Warfarin, Site II Diazepam)<\/li>\n<li>In Reis (OsrhHSA) oder Hefe hergestellt \u2013 vollst\u00e4ndig tierfrei und xenofrei<\/li>\n<li>Hauptfunktionen im serumfreien Medium: Fetts\u00e4uretr\u00e4ger, Radikalf\u00e4nger (ROS), L\u00f6sungsvermittler f\u00fcr Wirkstoffe\/Hormone, Beitrag zum osmotischen Druck<\/li>\n<li>In serumfreien Zellkulturmedien mit 1\u20135 g\/l eingesetzt, um die Albuminfunktion von FKS zu ersetzen<\/li>\n<li>Kritische Komponente in serumfreien AAV-Produktionsmedien \u2013 stabilisiert Viruspartikel bei Ernte und Aufreinigung<\/li>\n<li>F\u00fcr DMPK-fu,plasma-Assays: rHSA liefert humanrelevante Wirkstoffbindungskonstanten (BSA unterscheidet sich bei vielen sauren Wirkstoffen von HSA)<\/li>\n<li>In GMP-Qualit\u00e4t mit vollst\u00e4ndiger Herstellungsdokumentation f\u00fcr ATMP- und klinische Herstellung erh\u00e4ltlich<\/li>\n<li>SeamlessBio liefert OsrhHSA (in Reis exprimiert, \u226595 % Reinheit) in den Varianten Economy, Premium und CHO-exprimiert<\/li>\n<\/ul>\n\n<h2>Weiterlesen<\/h2>\n<ul>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/rhsa-vs-bsa-serum-free-cell-culture\/\">rHSA vs. BSA \u2013 was sollten Sie verwenden?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-xeno-free-cell-culture\/\">Was ist eine xeno-freie Zellkultur?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/anpassung-an-die-serumfreie-zellkultur\/\">Protokoll zur serumfreien Adaptation<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-recombinant-transferrin\/\">Was ist rekombinantes Transferrin?<\/a><\/li>\n<\/ul>\n\n<div style=\"background:#f4f6f7;border-radius:12px;padding:32px;text-align:center;margin-top:40px;\">\n<p style=\"font-size:18px;font-weight:700;color:#1a2e35;margin-bottom:12px;\">rHSA \u2013 Economy, Premium &amp; CHO-exprimiert | SeamlessBio<\/p>\n<p style=\"color:#6b7f82;margin-bottom:20px;\">Kostenloses Muster oder Angebot innerhalb von 48 Stunden anfordern.<\/p>\n<a href=\"https:\/\/seamlessbio.de\/de\/rhsa-uebersicht\/\" style=\"background:#18b7b2;color:#fff;padding:12px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Zum Produkt \u2192<\/a>\n&nbsp;&nbsp;\n<a href=\"https:\/\/seamlessbio.de\/de\/kontakt\/\" style=\"border:2px solid #18b7b2;color:#139b97;padding:10px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Muster anfordern<\/a>\n<\/div>\n\n<p style=\"font-size:13px;color:#6b7f82;margin-top:32px;border-top:1px solid #d8e8e7;padding-top:16px;\">\n<em>SeamlessBio \u00b7 Passau, Deutschland \u00b7 <a href=\"mailto:info@seamlessbio.de\">info@seamlessbio.de<\/a> \u00b7 +49 851 37932226<\/em>\n<\/p>\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Quick Definition What is rHSA (Recombinant Human Serum Albumin)?: Recombinant human serum albumin (rHSA) is human serum albumin produced by recombinant expression in non-animal systems \u2014 typically rice (Oryza sativa) or yeast (Pichia pastoris). It has an identical amino acid sequence to native human serum albumin but is produced without human donors or bovine sources, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","footnotes":""},"class_list":["post-2928","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is rHSA (Recombinant Human Serum Albumin)?<\/title>\n<meta name=\"description\" content=\"What is recombinant human serum albumin (rHSA), how is it produced, what does it do in serum-free cell culture, and when should you use it instead of BSA?\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/seamlessbio.de\/de\/what-is-rhsa-recombinant-human-serum-albumin\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is rHSA (Recombinant Human Serum Albumin)?\" \/>\n<meta property=\"og:description\" content=\"What is recombinant human serum albumin (rHSA), how is it produced, what does it do in serum-free cell culture, and when should you use it instead of BSA?\" \/>\n<meta property=\"og:url\" content=\"https:\/\/seamlessbio.de\/de\/what-is-rhsa-recombinant-human-serum-albumin\/\" \/>\n<meta property=\"og:site_name\" content=\"SeamlessBio\" \/>\n<meta property=\"article:modified_time\" content=\"2026-11-09T09:32:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/seamlessbio.de\/wp-content\/uploads\/2026\/04\/134428046.png\" \/>\n\t<meta property=\"og:image:width\" content=\"973\" \/>\n\t<meta property=\"og:image:height\" content=\"288\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-rhsa-recombinant-human-serum-albumin\\\/\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-rhsa-recombinant-human-serum-albumin\\\/\",\"name\":\"What is rHSA (Recombinant Human Serum Albumin)?\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#website\"},\"datePublished\":\"2026-08-22T14:51:30+00:00\",\"dateModified\":\"2026-11-09T09:32:42+00:00\",\"description\":\"What is recombinant human serum albumin (rHSA), how is it produced, what does it do in serum-free cell culture, and when should you use it instead of BSA?\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-rhsa-recombinant-human-serum-albumin\\\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/seamlessbio.de\\\/what-is-rhsa-recombinant-human-serum-albumin\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-rhsa-recombinant-human-serum-albumin\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Start\",\"item\":\"https:\\\/\\\/seamlessbio.de\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"What is rHSA (Recombinant Human Serum Albumin)?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#website\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/\",\"name\":\"SeamlessBio\",\"description\":\"Human serum, plasma and hPL, single-use bioprocessing bags, serum-free media, animal sera and FBS. 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