{"id":2938,"date":"2026-08-22T15:53:07","date_gmt":"2026-08-22T14:53:07","guid":{"rendered":"https:\/\/wheat-quail-856400.hostingersite.com\/?page_id=2938"},"modified":"2026-11-12T18:44:22","modified_gmt":"2026-11-12T17:44:22","slug":"what-is-recombinant-transferrin","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/what-is-recombinant-transferrin\/","title":{"rendered":"Was ist rekombinantes humanes Transferrin?"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"2938\" class=\"elementor elementor-2938\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c78fabe e-con e-atomic-element e-flexbox-base e-default-div e-b4c4ef8\" data-id=\"c78fabe\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"c78fabe\">\n    \t\t<div class=\"elementor-element elementor-element-bc00cee elementor-widget elementor-widget-html\" data-id=\"bc00cee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- \nWORDPRESS PAGE \u2014 PASTE INTO GUTENBERG \"BENUTZERDEFINIERTES HTML\" BLOCK\nYoast SEO:\n  Slug: what-is-recombinant-transferrin\n  SEO Title: What is Recombinant Human Transferrin? \u2014 Definition & Uses | SeamlessBio\n  Meta Description: What is recombinant human transferrin, what does it do in serum-free cell culture, and when do you need OsrhTF instead of bovine transferrin? Definition from SeamlessBio.\n  Focus Keyword: what is recombinant human transferrin serum-free\n  Meta Robots: index, follow\n  Page Type: Article\n-->\n\n<div style=\"background:#e9fbfa;border-left:4px solid #18b7b2;border-radius:0 8px 8px 0;padding:20px 24px;margin-bottom:32px;\">\n<p style=\"font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:1px;color:#139b97;margin-bottom:8px;\">Kurzdefinition<\/p>\n<p style=\"font-size:16px;margin:0;\"><strong>Was ist rekombinantes humanes Transferrin (OsrhTF)?<\/strong> Rekombinantes humanes Transferrin ist humanes Transferrin, das rekombinant in tierfreien Systemen (Reis, Hefe oder CHO-Zellen) exprimiert wird. Es versorgt Zellen in serumfreiem Kulturmedium \u00fcber die transferrinrezeptorvermittelte Endozytose mit Eisen \u2013 und ersetzt so die Eisenversorgung durch FKS, ohne tierische Bestandteile einzubringen.<\/p>\n<!-- BUY BOX (SEO: links to buy pages) -->\n<div class=\"sb-buy-box\" style=\"border:1px solid #cfe9e6;background:#f4fbfa;border-radius:12px;padding:22px 26px;margin:28px auto;max-width:1200px;box-sizing:border-box\">\n<h2 style=\"font-size:22px;line-height:1.3;margin:0 0 6px\">Albumin kaufen \u2013 HSA, rHSA und BSA ab EU-Lager<\/h2>\n<p style=\"margin:0 0 14px\">Angebot oder Testmuster anfragen \u2013 EU-Lager, Chargenreservierung bis zu 36 Monate.<\/p>\n<ul style=\"margin:0;padding-left:20px;columns:2 300px;column-gap:32px\">\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/?post_type=product&p=3537\" style=\"font-weight:700\">Rekombinantes humanes Transferrin<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/humanes-serumalbumin-hsa-pulver-96\/\">Humanes Serumalbumin (HSA) \u2013 Pulver \u226596 %<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/humanes-serumalbumin-hsa-5-prozent-loesung\/\">HSA-L\u00f6sung 5 %<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/humanes-serumalbumin-hsa-20-prozent-loesung\/\">HSA-L\u00f6sung 20 %<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/humanes-serumalbumin-hsa-25-prozent-loesung\/\">HSA-L\u00f6sung 25 %<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/rhsa-premium\/\">rHSA Premium \u2013 rekombinantes HSA<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/rhsa-economy-rekombinantes-humanes-serumalbumin\/\">rHSA Economy \u2013 rekombinantes HSA<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/bsa-standard-grade-bovines-serumalbumin\/\">BSA Standard Grade \u226596 %<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/bsa-frei-von-fettsauren\/\">BSA Fetts\u00e4urefrei<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/bsa-mit-niedrigem-endotoxingehalt\/\">Endotoxinarmes BSA<\/a><\/li>\n<\/ul>\n<p style=\"margin:14px 0 0\"><a href=\"https:\/\/seamlessbio.de\/de\/request-quote\/\" style=\"font-weight:600\">Angebot anfordern \u2192<\/a><\/p>\n<\/div>\n<!-- \/BUY BOX -->\n\n<\/div>\n\n<h2>Warum ist Transferrin in serumfreiem Medium unverzichtbar?<\/h2>\n<p>Iron is essential for haem biosynthesis, electron transport chain function (iron-sulfur clusters in Complex I, II, III), ribonucleotide reductase activity (DNA synthesis), and numerous other metabolic processes. In standard serum-containing medium, transferrin in FBS or human serum continuously delivers iron to cells. In serum-free medium, this delivery mechanism is absent \u2014 cells rapidly deplete the small intracellular iron stores and enter iron deficiency within 1\u20133 passages.<\/p>\n\n<h2>Warum rekombinantes statt bovines Transferrin?<\/h2>\n<p>Aus Rinderserum gewonnenes bovines Transferrin wird h\u00e4ufig in serumfreien Medien eingesetzt, ist aber tierischen Ursprungs \u2013 und damit unvereinbar mit xenofreien und ACF-Protokollen f\u00fcr die ATMP-Herstellung. OsrhTF (in Reis exprimiertes rekombinantes humanes Transferrin) ist funktionell identisch mit nativem humanem Transferrin, tierfrei und wird unter definierten Bedingungen mit hoher Chargenkonsistenz hergestellt. F\u00fcr die Zellherstellung in klinischer Qualit\u00e4t ersetzt rHSA + OsrhTF die Albumin- und Eisenversorgungsfunktion von FKS in einem vollst\u00e4ndig definierten, tierfreien Format.<\/p>\n\n<h2>OsrhTF in der Formulierung serumfreier Medien<\/h2>\n<p>Geben Sie OsrhTF in 5\u201310 \u00b5g\/ml zum serumfreien Basalmedium, zusammen mit rHSA (1\u20135 g\/l), rekombinantem Insulin (10 \u00b5g\/ml), Natriumselenit (5 ng\/ml) und zelltypspezifischen Wachstumsfaktoren. So sind die minimalen Tr\u00e4ger- und Eisenversorgungsfunktionen von FKS in einem definierten, tierfreien Format abgedeckt.<\/p>\n\n<h2>Wichtige Fakten<\/h2>\n<ul>\n<li>Transferrin ist ein eisenbindendes Glykoprotein von ~79 kDa \u2013 der wichtigste Eisentr\u00e4ger in Blut und Serum<\/li>\n<li>Zellen nehmen Eisen auf, indem diferrisches Transferrin (Tf-Fe2) an den Transferrinrezeptor 1 (TfR1) bindet \u2192 rezeptorvermittelte Endozytose \u2192 Eisenfreisetzung im Endosom \u2192 Apo-Transferrin wird zur Zelloberfl\u00e4che zur\u00fcckgef\u00fchrt<\/li>\n<li>Ohne Transferrin im serumfreien Medium werden Zellen innerhalb von 48\u201372 Stunden eisenlimitiert \u2192 geringere Proliferation \u2192 mitochondriale Dysfunktion \u2192 Apoptose<\/li>\n<li>Eisenmangel ist die am h\u00e4ufigsten \u00fcbersehene Ursache gescheiterter Serumfrei-Adaptionen<\/li>\n<li>OsrhTF (in Reis exprimiertes rekombinantes humanes Transferrin) ist tierfrei, xenofrei, \u226599 % Reinheit<\/li>\n<li>Standardkonzentration in serumfreiem Medium: 5\u201310 \u00b5g\/ml<\/li>\n<li>Eingesetzt in: serumfreien AAV-Produktionsmedien, iPSC-Erhaltung, MSC-Expansion, Satellitenzellkultur f\u00fcr kultiviertes Fleisch, jedem xenofreien oder ACF-Protokoll<\/li>\n<li>SeamlessBio liefert OsrhTF (in Oryza sativa exprimiertes rekombinantes humanes Transferrin)<\/li>\n<\/ul>\n\n<h2>Weiterlesen<\/h2>\n<ul>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-rhsa-recombinant-human-serum-albumin\/\">Was ist rHSA?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-xeno-free-cell-culture\/\">Was ist eine xeno-freie Zellkultur?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/anpassung-an-die-serumfreie-zellkultur\/\">Serumfrei-Adaption \u2013 warum sie scheitert<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/rhsa-vs-bsa-serum-free-cell-culture\/\">Vergleich rHSA vs. BSA<\/a><\/li>\n<\/ul>\n\n<div style=\"background:#f4f6f7;border-radius:12px;padding:32px;text-align:center;margin-top:40px;\">\n<p style=\"font-size:18px;font-weight:700;color:#1a2e35;margin-bottom:12px;\">OsrhTF \u2013 rekombinantes humanes Transferrin | SeamlessBio<\/p>\n<p style=\"color:#6b7f82;margin-bottom:20px;\">Muster oder Angebot innerhalb von 48 Stunden anfordern.<\/p>\n<a href=\"https:\/\/seamlessbio.de\/de\/request-quote\/\" style=\"background:#18b7b2;color:#fff;padding:12px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Zum Produkt \u2192<\/a>\n&nbsp;&nbsp;\n<a href=\"https:\/\/seamlessbio.de\/de\/kontakt\/\" style=\"border:2px solid #18b7b2;color:#139b97;padding:10px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Muster anfordern<\/a>\n<\/div>\n\n<p style=\"font-size:13px;color:#6b7f82;margin-top:32px;border-top:1px solid #d8e8e7;padding-top:16px;\">\n<em>SeamlessBio \u00b7 Passau, Deutschland \u00b7 <a href=\"mailto:info@seamlessbio.de\">info@seamlessbio.de<\/a> \u00b7 +49 851 37932226<\/em>\n<\/p>\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Quick Definition What is Recombinant Human Transferrin (OsrhTF)?: Recombinant human transferrin is human transferrin produced by recombinant expression in non-animal systems (rice, yeast, or CHO cells). It delivers iron to cells in serum-free culture medium via transferrin receptor-mediated endocytosis \u2014 replacing the iron delivery function of FBS without introducing animal-derived components. Buy albumin \u2013 HSA, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","footnotes":""},"class_list":["post-2938","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is Recombinant Human Transferrin? \u2014 Definition &amp; Uses<\/title>\n<meta name=\"description\" content=\"What is recombinant human transferrin, what does it do in serum-free cell culture, and when do you need OsrhTF instead of bovine transferrin? 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