{"id":2943,"date":"2026-08-22T20:57:59","date_gmt":"2026-08-22T19:57:59","guid":{"rendered":"https:\/\/wheat-quail-856400.hostingersite.com\/?page_id=2943"},"modified":"2026-11-12T18:44:19","modified_gmt":"2026-11-12T17:44:19","slug":"what-is-fbs-low-igg","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/what-is-fbs-low-igg\/","title":{"rendered":"Was ist geringes IgG FBS?"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"2943\" class=\"elementor elementor-2943\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b75c108 e-con e-atomic-element e-flexbox-base e-default-div e-02f0ef7\" data-id=\"b75c108\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"b75c108\">\n    \t\t<div class=\"elementor-element elementor-element-489da2b elementor-widget elementor-widget-html\" data-id=\"489da2b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- \nWORDPRESS PAGE \u2014 GUTENBERG \"BENUTZERDEFINIERTES HTML\" BLOCK\nSlug: what-is-fbs-low-igg\nSEO Title: What is FBS Low IgG? \u2014 Definition & Hybridoma Use | SeamlessBio\nMeta Description: What is FBS Low IgG, what bovine IgG level does it contain, and when do you need it for hybridoma culture and Protein A purification?\nFocus Keyword: what is FBS Low IgG\nAdditional Keywords: FBS low IgG hybridoma, fetal bovine serum low immunoglobulin, FBS low IgG protein A purification\nMenu: Resources \u2192 Glossary\n-->\n<div style=\"background:#e9fbfa;border-left:4px solid #18b7b2;border-radius:0 8px 8px 0;padding:20px 24px;margin-bottom:32px;\">\n<p style=\"font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:1px;color:#139b97;margin-bottom:8px;\">Kurzdefinition<\/p>\n<p style=\"font-size:16px;margin:0;\"><strong>Was ist FKS Low IgG?:<\/strong> FBS Low IgG is fetal bovine serum processed to reduce bovine immunoglobulin G to less than 200 \u00b5g\/mL, compared to 50\u2013200 \u00b5g\/mL in standard FBS. It is used in hybridoma monoclonal antibody production where bovine IgG co-purification during Protein A\/G affinity chromatography contaminates the final antibody product.<\/p>\n<!-- BUY BOX (SEO: links to buy pages) -->\n<div class=\"sb-buy-box\" style=\"border:1px solid #cfe9e6;background:#f4fbfa;border-radius:12px;padding:22px 26px;margin:28px auto;max-width:1200px;box-sizing:border-box\">\n<h2 style=\"font-size:22px;line-height:1.3;margin:0 0 6px\">Fetales K\u00e4lberserum (FKS) ab EU-Lager kaufen<\/h2>\n<p style=\"margin:0 0 14px\">Angebot oder Testmuster anfordern \u2013 Lager in der EU, ohne Mindestmenge, Chargenreservierung bis zu 36 Monate.<\/p>\n<ul style=\"margin:0;padding-left:20px;columns:2 300px;column-gap:32px\">\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fks-low-igg\/\" style=\"font-weight:700\">FKS Ultra Low IgG (&lt;5 \u00b5g\/ml)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fetales-kaelberserum-fks-suedamerika\/\">Fetales K\u00e4lberserum \u2013 Herkunft S\u00fcdamerika<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fetales-kaelberserum-fks-usa\/\">Fetales K\u00e4lberserum \u2013 Herkunft USA<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fetales-kaelberserum-fks-australien\/\">Fetales K\u00e4lberserum \u2013 Herkunft Australien<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fks-tetrazyklinfrei-tet-free\/\">Tetrazyklinfreies FKS (Tet-free)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fks-hitzeinaktiviert-usa-australien-suedamerika\/\">FKS hitzeinaktiviert<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fks-es-zell-getestet-suedamerika\/\">ES-Zell-getestetes FKS<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fks-low-endotoxin-suedamerika\/\">FBS Geringer Endotoxingehalt (&lt;1 EU\/ml)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fks-maennlich-testosteron-definiert\/\">FKS m\u00e4nnlich \u2013 Testosteron-definiert<\/a><\/li>\n\n<\/ul>\n<p style=\"margin:14px 0 0\"><a href=\"https:\/\/seamlessbio.de\/de\/request-quote\/\" style=\"font-weight:600\">Angebot anfordern \u2192<\/a><\/p>\n<\/div>\n<!-- \/BUY BOX -->\n\n<\/div>\n<h2>Wann brauchen Sie FKS Low IgG?<\/h2>\n<p>Bei Hybridomfusion und Klonierung durch limitierende Verd\u00fcnnung ist Standard-FKS mit 15 % richtig \u2013 Priorit\u00e4t haben maximale Wachstumsunterst\u00fctzung und Klonierungseffizienz. Im Produktionsma\u00dfstab senkt der Wechsel auf FKS Low IgG die bovine IgG-Last im Kultur\u00fcberstand vor der Protein-A\/G-Aufreinigung. Bei schwach produzierenden Hybridomen mit &lt;20 \u00b5g\/ml mAb kann das bovine IgG aus Standard-FKS die mAb-Konzentration \u00fcbersteigen und die Aufreinigung verschlechtern. FKS Low IgG l\u00f6st das ohne Umstellung auf serumfrei.<\/p>\n<h2>Low IgG vs. Ultra Low IgG<\/h2>\n<p>FKS Low IgG (&lt;200 \u00b5g\/ml) reicht f\u00fcr die mAb-Produktion in Forschungsqualit\u00e4t, wenn &gt;85 % Reinheit nach einem einzigen Protein-A-Schritt gen\u00fcgen. FKS Ultra Low IgG (&lt;5 \u00b5g\/ml) ist f\u00fcr die Herstellung diagnostischer Antik\u00f6rper oder jede Anwendung erforderlich, bei der Kreuzreaktivit\u00e4t mit bovinem IgG den Assay st\u00f6ren w\u00fcrde.<\/p>\n<h2>Wichtige Fakten<\/h2>\n<ul>\n<li>Standard-FKS enth\u00e4lt 50\u2013200 \u00b5g\/ml bovines IgG \u2013 eine erhebliche Verunreinigung Protein-A\/G-gereinigter muriner mAb-Eluate<\/li>\n<li>FKS Low IgG: &lt;200 \u00b5g\/ml bovines IgG \u2013 f\u00fcr die mAb-Produktion in Forschungsqualit\u00e4t<\/li>\n<li>FKS Ultra Low IgG: &lt;5 \u00b5g\/ml \u2013 erforderlich f\u00fcr Antik\u00f6rper in Diagnostik- oder Therapiequalit\u00e4t<\/li>\n<li>Bovines und murines IgG eluieren bei pH 2,8 gemeinsam von Protein-A\/G-S\u00e4ulen \u2013 nach der Aufreinigung nicht mehr trennbar<\/li>\n<li>Erst in der Produktionsphase von Standard-FKS auf Low IgG umstellen \u2013 f\u00fcr Fusion und Klonierung gen\u00fcgt Standard-FKS<\/li>\n<li>Bei SeamlessBio in 50 ml, 100 ml und 500 ml erh\u00e4ltlich<\/li>\n<\/ul>\n<h2>Weiterlesen<\/h2>\n<ul>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-fbs\/\">Was ist FBS?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-fbs-ultra-low-igg\/\">Was ist FBS Ultra Low IgG?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/anwendungen\/hybridoma-monoclonal-antibody-production\/\">Leitfaden Hybridom- &amp; mAb-Produktion<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/produkte\/fetales-kaelberserum\/\">FKS-Portfolio \u2013 alle Qualit\u00e4ten<\/a><\/li>\n<\/ul>\n<div style=\"background:#f4f6f7;border-radius:12px;padding:32px;text-align:center;margin-top:40px;\">\n<p style=\"font-size:18px;font-weight:700;color:#1a2e35;margin-bottom:12px;\">FKS Low IgG (&lt;200 \u00b5g\/ml) \u2013 erh\u00e4ltlich bei SeamlessBio<\/p>\n<a href=\"https:\/\/seamlessbio.de\/de\/produkte\/fks-low-igg\/\" style=\"background:#18b7b2;color:#fff;padding:12px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Zum Produkt \u2192<\/a>\n&nbsp;&nbsp;\n<a href=\"https:\/\/seamlessbio.de\/de\/kontakt\/\" style=\"border:2px solid #18b7b2;color:#139b97;padding:10px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Muster anfordern<\/a>\n<\/div>\n<p style=\"font-size:13px;color:#6b7f82;margin-top:32px;border-top:1px solid #d8e8e7;padding-top:16px;\">\n<em>SeamlessBio \u00b7 Passau, Deutschland \u00b7 <a href=\"mailto:info@seamlessbio.de\">info@seamlessbio.de<\/a><\/em>\n<\/p>\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Quick Definition What is FBS Low IgG?: FBS Low IgG is fetal bovine serum processed to reduce bovine immunoglobulin G to less than 200 \u00b5g\/mL, compared to 50\u2013200 \u00b5g\/mL in standard FBS. It is used in hybridoma monoclonal antibody production where bovine IgG co-purification during Protein A\/G affinity chromatography contaminates the final antibody product. Buy [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","footnotes":""},"class_list":["post-2943","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is FBS Low IgG? \u2014 Definition &amp; Hybridoma Use<\/title>\n<meta name=\"description\" content=\"What is FBS Low IgG, what bovine IgG level does it contain, and when do you need it for hybridoma culture and Protein A purification?\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/seamlessbio.de\/de\/what-is-fbs-low-igg\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is FBS Low IgG? \u2014 Definition &amp; Hybridoma Use\" \/>\n<meta property=\"og:description\" content=\"What is FBS Low IgG, what bovine IgG level does it contain, and when do you need it for hybridoma culture and Protein A purification?\" \/>\n<meta property=\"og:url\" content=\"https:\/\/seamlessbio.de\/de\/what-is-fbs-low-igg\/\" \/>\n<meta property=\"og:site_name\" content=\"SeamlessBio\" \/>\n<meta property=\"article:modified_time\" content=\"2026-11-12T17:44:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/seamlessbio.de\/wp-content\/uploads\/2026\/04\/134428046.png\" \/>\n\t<meta property=\"og:image:width\" content=\"973\" \/>\n\t<meta property=\"og:image:height\" content=\"288\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-fbs-low-igg\\\/\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-fbs-low-igg\\\/\",\"name\":\"What is FBS Low IgG? \u2014 Definition & Hybridoma Use\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#website\"},\"datePublished\":\"2026-08-22T19:57:59+00:00\",\"dateModified\":\"2026-11-12T17:44:19+00:00\",\"description\":\"What is FBS Low IgG, what bovine IgG level does it contain, and when do you need it for hybridoma culture and Protein A purification?\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-fbs-low-igg\\\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/seamlessbio.de\\\/what-is-fbs-low-igg\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-fbs-low-igg\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Start\",\"item\":\"https:\\\/\\\/seamlessbio.de\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"What is FBS Low IgG?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#website\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/\",\"name\":\"SeamlessBio\",\"description\":\"Human serum, plasma and hPL, single-use bioprocessing bags, serum-free media, animal sera and FBS. 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