{"id":2948,"date":"2026-08-22T20:59:33","date_gmt":"2026-08-22T19:59:33","guid":{"rendered":"https:\/\/seamlessbio.de\/?page_id=2948"},"modified":"2026-08-23T00:46:19","modified_gmt":"2026-08-22T23:46:19","slug":"what-is-fbs-ultra-low-igg","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/what-is-fbs-ultra-low-igg\/","title":{"rendered":"What is FBS Ultra Low IgG?"},"content":{"rendered":"
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Quick Definition<\/p>\n

What is FBS Ultra Low IgG?:<\/strong> FBS Ultra Low IgG is fetal bovine serum processed to reduce bovine IgG to less than 5 \u00b5g\/mL \u2014 the industry standard for diagnostic-grade monoclonal antibody production and high-sensitivity immunoassay development where trace bovine IgG contamination would cause assay interference or reduce antibody purity below acceptable limits.<\/p>\n<\/div>\n

When is Ultra Low IgG required vs Low IgG FBS?<\/h2>\n

FBS Low IgG (<200 \u00b5g\/mL) is sufficient for most research applications where final mAb purity after Protein A is >85%. FBS Ultra Low IgG (<5 \u00b5g\/mL) is required when the mAb will be used as a diagnostic antibody where bovine IgG cross-reactivity creates false positives; when EU IVDR or FDA 510(k) submissions require demonstrated absence of bovine IgG interference; when the hybridoma produces <10 \u00b5g\/mL mAb; or for therapeutic antibody research where xenogenic protein contamination must be minimised.<\/p>\n

Key Facts<\/h2>\n