{"id":2953,"date":"2026-08-22T21:00:10","date_gmt":"2026-08-22T20:00:10","guid":{"rendered":"https:\/\/wheat-quail-856400.hostingersite.com\/?page_id=2953"},"modified":"2026-11-12T18:44:13","modified_gmt":"2026-11-12T17:44:13","slug":"what-is-gamma-irradiated-fbs","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/what-is-gamma-irradiated-fbs\/","title":{"rendered":"Was ist gamma-bestrahltes FBS?"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"2953\" class=\"elementor elementor-2953\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f593731 e-con e-atomic-element e-flexbox-base e-default-div e-742afe3\" data-id=\"f593731\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"f593731\">\n    \t\t<div class=\"elementor-element elementor-element-8b9b290 elementor-widget elementor-widget-html\" data-id=\"8b9b290\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- \nWORDPRESS PAGE \u2014 GUTENBERG \"BENUTZERDEFINIERTES HTML\" BLOCK\nSlug: what-is-gamma-irradiated-fbs\nSEO Title: What is Gamma Irradiated FBS? \u2014 Definition & GMP Use | SeamlessBio\nMeta Description: What is gamma irradiated FBS, what does irradiation inactivate, when is it required for GMP and ATMP manufacturing? Definition from SeamlessBio.\nFocus Keyword: what is gamma irradiated FBS\nAdditional Keywords: gamma irradiated fetal bovine serum GMP, FBS gamma irradiation viral inactivation, irradiated FBS ATMP manufacturing\nMenu: Resources \u2192 Glossary\n-->\n<div style=\"background:#e9fbfa;border-left:4px solid #18b7b2;border-radius:0 8px 8px 0;padding:20px 24px;margin-bottom:32px;\">\n<p style=\"font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:1px;color:#139b97;margin-bottom:8px;\">Kurzdefinition<\/p>\n<p style=\"font-size:16px;margin:0;\"><strong>Was ist gammabestrahltes FKS?:<\/strong> Gammabestrahltes FKS ist f\u00f6tales K\u00e4lberserum, das ionisierender Gammastrahlung (typischerweise 25\u201345 kGy) ausgesetzt wurde, um Viren, Mykoplasmen und andere Fremdagenzien zu inaktivieren. Es bietet \u00fcber die Standard-QC hinaus eine zus\u00e4tzliche Virussicherheitsstufe f\u00fcr GMP-Zellkultur und ATMP-Herstellung.<\/p>\n<!-- BUY BOX (SEO: links to buy pages) -->\n<div class=\"sb-buy-box\" style=\"border:1px solid #cfe9e6;background:#f4fbfa;border-radius:12px;padding:22px 26px;margin:28px auto;max-width:1200px;box-sizing:border-box\">\n<h2 style=\"font-size:22px;line-height:1.3;margin:0 0 6px\">Fetales K\u00e4lberserum (FKS) ab EU-Lager kaufen<\/h2>\n<p style=\"margin:0 0 14px\">Angebot oder Testmuster anfordern \u2013 Lager in der EU, ohne Mindestmenge, Chargenreservierung bis zu 36 Monate.<\/p>\n<ul style=\"margin:0;padding-left:20px;columns:2 300px;column-gap:32px\">\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fetales-kaelberserum-fks-suedamerika\/\">Fetales K\u00e4lberserum \u2013 Herkunft S\u00fcdamerika<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fetales-kaelberserum-fks-usa\/\">Fetales K\u00e4lberserum \u2013 Herkunft USA<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fetales-kaelberserum-fks-australien\/\">Fetales K\u00e4lberserum \u2013 Herkunft Australien<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fks-low-igg\/\">FKS Ultra Low IgG (&lt;5 \u00b5g\/ml)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fks-tetrazyklinfrei-tet-free\/\">Tetrazyklinfreies FKS (Tet-free)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fks-hitzeinaktiviert-usa-australien-suedamerika\/\">FKS hitzeinaktiviert<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fks-es-zell-getestet-suedamerika\/\">ES-Zell-getestetes FKS<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fks-low-endotoxin-suedamerika\/\">FBS Geringer Endotoxingehalt (&lt;1 EU\/ml)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/fks-maennlich-testosteron-definiert\/\">FKS m\u00e4nnlich \u2013 Testosteron-definiert<\/a><\/li>\n\n<\/ul>\n<p style=\"margin:14px 0 0\"><a href=\"https:\/\/seamlessbio.de\/de\/request-quote\/\" style=\"font-weight:600\">Angebot anfordern \u2192<\/a><\/p>\n<\/div>\n<!-- \/BUY BOX -->\n\n<\/div>\n<h2>Wann ist gammabestrahltes FKS erforderlich?<\/h2>\n<p>Gammabestrahltes FKS ist erforderlich oder dringend empfohlen in der ATMP-Herstellung (CAR-T, MSC, NK-Zellen), wenn eine virale Kontamination des Zellprodukts ein Risiko f\u00fcr Patienten darstellt; in der GMP-Herstellung, wenn die Risikobewertung validierte Virusinaktivierungsschritte verlangt; und bei der Herstellung von Pr\u00fcfpr\u00e4paraten unter IND, wenn die Beh\u00f6rden \u00fcber die Standard-Chargenpr\u00fcfung hinaus zus\u00e4tzliche Kontrollen von Fremdagenzien erwarten.<\/p>\n<h2>Beeinflusst die Bestrahlung die Zellkulturleistung?<\/h2>\n<p>Die Gammabestrahlung verringert die Wachstumsfaktoraktivit\u00e4t je nach Dosis um 10\u201330 %. Manche Zelllinien wachsen langsamer, andere zeigen keinen Unterschied. Validieren Sie bestrahltes FKS immer gegen Ihre nicht bestrahlte Referenzcharge. Die Klonierungseffizienz von Hybridomen und die Transfektionseffizienz von HEK293T reagieren besonders empfindlich auf die bestrahlungsbedingte Abnahme der Wachstumsfaktoren.<\/p>\n<h2>Wichtige Fakten<\/h2>\n<ul>\n<li>Standarddosis: 25\u201345 kGy Gammastrahlung aus einer Co-60-Quelle<\/li>\n<li>Inaktiviert: BVDV, BHV-1, BRSV, PI-3, Mykoplasmen, die meisten beh\u00fcllten und unbeh\u00fcllten Viren<\/li>\n<li>Inaktiviert NICHT: Prionen (TSE\/BSE) \u2013 die Gammabestrahlung ist kein validierter Schritt zur Prionenreduktion<\/li>\n<li>Wachstumsfaktoraktivit\u00e4t um 10\u201330 % reduziert \u2013 ggf. zelllinienspezifische Optimierung n\u00f6tig<\/li>\n<li>Geliefert mit Bestrahlungszertifikat inklusive Dosis-Mapping und Dosimetriebericht<\/li>\n<li>Von EMA und FDA als Virusreduktionsschritt in der GMP-Risikobewertung von Rohstoffen f\u00fcr die ATMP-Herstellung akzeptiert<\/li>\n<\/ul>\n<h2>Weiterlesen<\/h2>\n<ul>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-fbs\/\">Was ist FBS?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/ressourcen\/blog\/fbs-bvdv-testing-cpe-rna-qpcr-guide\/\">Leitfaden zur BVDV-Pr\u00fcfung von FKS<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/anwendungen\/aav-viral-vector-production\/\">Leitfaden zur Produktion viraler AAV-Vektoren<\/a><\/li>\n<\/ul>\n<div style=\"background:#f4f6f7;border-radius:12px;padding:32px;text-align:center;margin-top:40px;\">\n<p style=\"font-size:18px;font-weight:700;color:#1a2e35;margin-bottom:12px;\">FKS gammabestrahlt \u2013 erh\u00e4ltlich bei SeamlessBio<\/p>\n<a href=\"https:\/\/seamlessbio.de\/de\/produkte\/fks-gammabestrahlt\/\" style=\"background:#18b7b2;color:#fff;padding:12px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Zum Produkt \u2192<\/a>\n&nbsp;&nbsp;\n<a href=\"https:\/\/seamlessbio.de\/de\/kontakt\/\" style=\"border:2px solid #18b7b2;color:#139b97;padding:10px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Muster anfordern<\/a>\n<\/div>\n<p style=\"font-size:13px;color:#6b7f82;margin-top:32px;border-top:1px solid #d8e8e7;padding-top:16px;\">\n<em>SeamlessBio \u00b7 Passau, Deutschland \u00b7 <a href=\"mailto:info@seamlessbio.de\">info@seamlessbio.de<\/a><\/em>\n<\/p>\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Quick Definition What is Gamma Irradiated FBS?: Gamma irradiated FBS is fetal bovine serum exposed to ionising gamma radiation (typically 25\u201345 kGy) to inactivate viruses, mycoplasma, and other adventitious agents. It provides an additional viral safety layer for GMP cell culture and ATMP manufacturing beyond standard QC testing. Buy fetal bovine serum (FBS) from EU [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","footnotes":""},"class_list":["post-2953","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is Gamma Irradiated FBS? \u2014 Definition &amp; GMP Use<\/title>\n<meta name=\"description\" content=\"What is gamma irradiated FBS, what does irradiation inactivate, when is it required for GMP and ATMP manufacturing? 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