{"id":3033,"date":"2026-08-22T21:13:31","date_gmt":"2026-08-22T20:13:31","guid":{"rendered":"https:\/\/wheat-quail-856400.hostingersite.com\/?page_id=3033"},"modified":"2026-11-02T16:24:56","modified_gmt":"2026-11-02T15:24:56","slug":"what-is-mrp2-abcc2","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/what-is-mrp2-abcc2\/","title":{"rendered":"Was ist MRP2?"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"3033\" class=\"elementor elementor-3033\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d90c789 e-con e-atomic-element e-flexbox-base e-default-div e-f0f2195\" data-id=\"d90c789\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"d90c789\">\n    \t\t<div class=\"elementor-element elementor-element-383a8f6 elementor-widget elementor-widget-html\" data-id=\"383a8f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- \nWORDPRESS PAGE \u2014 GUTENBERG \"BENUTZERDEFINIERTES HTML\" BLOCK\nSlug: what-is-mrp2-abcc2\nSEO Title: What is MRP2 (ABCC2)? \u2014 Definition & Cholestasis Risk | SeamlessBio\nMeta Description: What is MRP2 (ABCC2), its role in hepatic efflux, and why MRP2 inhibition is linked to cholestasis and DILI in drug development?\nFocus Keyword: what is MRP2 ABCC2 hepatic transporter\nAdditional Keywords: MRP2 ABCC2 hepatic efflux cholestasis, MRP2 inhibition drug liver injury, MRP2 vesicle assay DMPK\nMenu: Resources \u2192 Glossary\n-->\n<div style=\"background:#e9fbfa;border-left:4px solid #18b7b2;border-radius:0 8px 8px 0;padding:20px 24px;margin-bottom:32px;\">\n<p style=\"font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:1px;color:#139b97;margin-bottom:8px;\">Kurzdefinition<\/p>\n<p style=\"font-size:16px;margin:0;\"><strong>Was ist MRP2 (Multidrug Resistance-Associated Protein 2 \/ ABCC2)?:<\/strong> MRP2 (ABCC2, cMOAT) ist ein ABC-Efflux-Transporter in der kanalikul\u00e4ren Membran der Hepatozyten, der organische Anionen, Glucuronid- und Sulfatkonjugate, Glutathionkonjugate und Gallensalze in die Galle ausscheidet. Eine MRP2-Hemmung verringert die bili\u00e4re Ausscheidung dieser Substrate und tr\u00e4gt zu intrahepatischer Cholestase und arzneimittelinduzierter Lebersch\u00e4digung bei.<\/p>\n<!-- BUY BOX (SEO: links to buy pages) -->\n<div class=\"sb-buy-box\" style=\"border:1px solid #cfe9e6;background:#f4fbfa;border-radius:12px;padding:22px 26px;margin:28px auto;max-width:1200px;box-sizing:border-box\">\n<h2 style=\"font-size:22px;line-height:1.3;margin:0 0 6px\">ABC-Transporter-Vesikelkits kaufen (aus HEK293)<\/h2>\n<p style=\"margin:0 0 14px\">Angebot f\u00fcr P-gp-, BCRP-, BSEP- und MRP-Vesikelkits f\u00fcr In-vitro-DDI-Studien anfragen.<\/p>\n<ul style=\"margin:0;padding-left:20px;columns:2 300px;column-gap:32px\">\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/mrp2-vesikelkit-abcc2-hek293\/\" style=\"font-weight:700\">MRP2-Vesikelkit (ABCC2)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/p-gp-vesikelkit-mdr1-hek293\/\">P-gp-Vesikelkit (MDR1\/ABCB1)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/bcrp-vesikelkit-abcg2-hek293\/\">BCRP-Vesikelkit (ABCG2)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/bsep-vesikelkit-abcb11-hek293\/\">BSEP-Vesikelkit (ABCB11)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/mrp1-vesikelkit-abcc1-hek293\/\">MRP1-Vesikelkit (ABCC1)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/mrp3-vesikelkit-abcc3-hek293\/\">MRP3-Vesikelkit (ABCC3)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/mrp4-vesikelkit-abcc4-hek293\/\">MRP4-Vesikelkit (ABCC4)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/mrp5-vesikelkit-abcc5-hek293\/\">MRP5-Vesikelkit (ABCC5)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/mrp8-vesikelkit-abcc11-hek293\/\">MRP8-Vesikelkit (ABCC11)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/p-gp-vesikelkit-fluopgp-substrat\/\">P-gp-Vesikelkit mit FluoPgp-Substrat<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/kontroll-vesikelkit-hek293\/\">Kontroll-Vesikelkit (Negativkontrolle)<\/a><\/li>\n<\/ul>\n<p style=\"margin:14px 0 0\"><a href=\"https:\/\/seamlessbio.de\/de\/request-quote\/\" style=\"font-weight:600\">Angebot anfordern \u2192<\/a><\/p>\n<\/div>\n<!-- \/BUY BOX -->\n\n<\/div>\n<h2>Warum BSEP und MRP2 oft gemeinsam bewertet werden<\/h2>\n<p>BSEP und MRP2 arbeiten in der kanalikul\u00e4ren Membran der Hepatozyten zusammen. Viele cholestatische Arzneimittel hemmen beide gleichzeitig \u2013 der klinische Schweregrad einer cholestatischen DILI korreliert mit der kombinierten Hemmung von BSEP und MRP2. MRP2 zus\u00e4tzlich zum BSEP-Vesikelpanel zu testen ist praktisch und kosteneffizient: gleiches Assayformat, \u00e4hnliche Inkubationsbedingungen und ein aussagekr\u00e4ftigeres Ergebnis als BSEP allein.<\/p>\n<h2>MRP2 und Dubin-Johnson-Syndrom<\/h2>\n<p>Ein genetischer MRP2-Mangel (Dubin-Johnson-Syndrom) verursacht eine symptomlose konjugierte Hyperbilirubin\u00e4mie \u2013 der gutartige klinische Ph\u00e4notyp best\u00e4tigt MRP2 als relevantes DDI-Ziel und erkl\u00e4rt, warum manche Arzneimittel eine arzneimittelbedingte konjugierte Hyperbilirubin\u00e4mie ohne vollst\u00e4ndige cholestatische DILI ausl\u00f6sen.<\/p>\n<h2>Wichtige Fakten<\/h2>\n<ul>\n<li>Lokalisiert in der kanalikul\u00e4ren Membran der Hepatozyten \u2013 derselben Membran wie BSEP<\/li>\n<li>Transportiert: Glucuronidkonjugate (Bilirubindiglucuronid), Sulfatkonjugate, Glutathionkonjugate, Methotrexat, Cisplatin<\/li>\n<li>MRP2-Hemmung \u2192 verringerte bili\u00e4re Bilirubinausscheidung \u2192 konjugierte Hyperbilirubin\u00e4mie (cholestatischer Ikterus)<\/li>\n<li>Wird oft von denselben Arzneimitteln wie BSEP mitgehemmt \u2013 die kombinierte Hemmung von BSEP + MRP2 verursacht die schwersten cholestatischen DILI<\/li>\n<li>Die EMA empfiehlt MRP2-Tests, wenn pr\u00e4klinische\/klinische Daten Hinweise auf Cholestase oder konjugierte Hyperbilirubin\u00e4mie zeigen<\/li>\n<li>In vitro: Inside-out-Membranvesikelassay mit HEK293-MRP2-Vesikeln und Glutathion-Methylfluorescein als Sonde<\/li>\n<\/ul>\n<h2>Weiterlesen<\/h2>\n<ul>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-bsep\/\">Was ist BSEP?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-dili-drug-induced-liver-injury\/\">Was ist DILI?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/ressourcen\/blog\/fda-ema-mandatory-drug-transporters-ind-dmpk-guide\/\">Verpflichtende Transporter nach FDA &amp; EMA<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/produkte\/dmpk-transporter-assays\/\">DMPK-Kit-Portfolio<\/a><\/li>\n<\/ul>\n<div style=\"background:#f4f6f7;border-radius:12px;padding:32px;text-align:center;margin-top:40px;\">\n<p style=\"font-size:18px;font-weight:700;color:#1a2e35;margin-bottom:12px;\">MRP2 (ABCC2) Vesikel-Kit \u2013 Cell4Pharma \u00fcber SeamlessBio<\/p>\n<a href=\"https:\/\/seamlessbio.de\/de\/produkte\/dmpk-transporter-assays\/mrp2-vesicle-kit\/\" style=\"background:#18b7b2;color:#fff;padding:12px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Zum Produkt \u2192<\/a>\n&nbsp;&nbsp;\n<a href=\"https:\/\/seamlessbio.de\/de\/kontakt\/\" style=\"border:2px solid #18b7b2;color:#139b97;padding:10px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Muster anfordern<\/a>\n<\/div>\n<p style=\"font-size:13px;color:#6b7f82;margin-top:32px;border-top:1px solid #d8e8e7;padding-top:16px;\">\n<em>SeamlessBio \u00b7 Passau, Deutschland \u00b7 <a href=\"mailto:info@seamlessbio.de\">info@seamlessbio.de<\/a><\/em>\n<\/p>\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Quick Definition What is MRP2 (Multidrug Resistance-Associated Protein 2 \/ ABCC2)?: MRP2 (ABCC2, cMOAT) is an ABC efflux transporter on the canalicular membrane of hepatocytes that exports organic anions, glucuronide and sulfate conjugates, glutathione conjugates, and bile salts into bile. MRP2 inhibition reduces biliary excretion of these substrates, contributing to intrahepatic cholestasis and drug-induced liver [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","footnotes":""},"class_list":["post-3033","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is MRP2 (ABCC2)? \u2014 Definition &amp; Cholestasis Risk<\/title>\n<meta name=\"description\" content=\"What is MRP2 (ABCC2), its role in hepatic efflux, and why MRP2 inhibition is linked to cholestasis and DILI in drug development?\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/seamlessbio.de\/de\/what-is-mrp2-abcc2\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is MRP2 (ABCC2)? \u2014 Definition &amp; Cholestasis Risk\" \/>\n<meta property=\"og:description\" content=\"What is MRP2 (ABCC2), its role in hepatic efflux, and why MRP2 inhibition is linked to cholestasis and DILI in drug development?\" \/>\n<meta property=\"og:url\" content=\"https:\/\/seamlessbio.de\/de\/what-is-mrp2-abcc2\/\" \/>\n<meta property=\"og:site_name\" content=\"SeamlessBio\" \/>\n<meta property=\"article:modified_time\" content=\"2026-11-02T15:24:56+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/seamlessbio.de\/wp-content\/uploads\/2026\/04\/134428046.png\" \/>\n\t<meta property=\"og:image:width\" content=\"973\" \/>\n\t<meta property=\"og:image:height\" content=\"288\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-mrp2-abcc2\\\/\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-mrp2-abcc2\\\/\",\"name\":\"What is MRP2 (ABCC2)? \u2014 Definition & Cholestasis Risk\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#website\"},\"datePublished\":\"2026-08-22T20:13:31+00:00\",\"dateModified\":\"2026-11-02T15:24:56+00:00\",\"description\":\"What is MRP2 (ABCC2), its role in hepatic efflux, and why MRP2 inhibition is linked to cholestasis and DILI in drug development?\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-mrp2-abcc2\\\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/seamlessbio.de\\\/what-is-mrp2-abcc2\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-mrp2-abcc2\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Start\",\"item\":\"https:\\\/\\\/seamlessbio.de\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"What is MRP2 (ABCC2)?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#website\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/\",\"name\":\"SeamlessBio\",\"description\":\"Human serum, plasma and hPL, single-use bioprocessing bags, serum-free media, animal sera and FBS. 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