{"id":3038,"date":"2026-08-22T21:14:16","date_gmt":"2026-08-22T20:14:16","guid":{"rendered":"https:\/\/wheat-quail-856400.hostingersite.com\/?page_id=3038"},"modified":"2026-11-09T10:19:36","modified_gmt":"2026-11-09T09:19:36","slug":"what-is-abc-transporter","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/what-is-abc-transporter\/","title":{"rendered":"Was ist ein ABC Transporter?"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"3038\" class=\"elementor elementor-3038\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2042bd9 e-con e-atomic-element e-flexbox-base e-default-div e-45cd434\" data-id=\"2042bd9\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"2042bd9\">\n    \t\t<div class=\"elementor-element elementor-element-a880240 elementor-widget elementor-widget-html\" data-id=\"a880240\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- \nWORDPRESS PAGE \u2014 GUTENBERG \"BENUTZERDEFINIERTES HTML\" BLOCK\nSlug: what-is-abc-transporter\nSEO Title: What is an ABC Transporter? \u2014 Definition & Drug Development Role | SeamlessBio\nMeta Description: What is an ABC transporter, how do ATP-binding cassette transporters work, and which are important for drug development DDI assessment?\nFocus Keyword: what is ABC transporter drug development\nAdditional Keywords: ABC transporter definition ATP-binding cassette, ABC efflux transporter drug interaction, P-gp BCRP BSEP MRP ABC transporter\nMenu: Resources \u2192 Glossary\n-->\n<div style=\"background:#e9fbfa;border-left:4px solid #18b7b2;border-radius:0 8px 8px 0;padding:20px 24px;margin-bottom:32px;\">\n<p style=\"font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:1px;color:#139b97;margin-bottom:8px;\">Kurzdefinition<\/p>\n<p style=\"font-size:16px;margin:0;\"><strong>Was ist ein ABC-Transporter?<\/strong> ATP-Binding-Cassette-(ABC-)Transporter sind Membranproteine, die mithilfe der ATP-Hydrolyse Substrate aktiv und gegen ein Konzentrationsgef\u00e4lle \u00fcber Zellmembranen transportieren. In der Pharmakokinetik steuern ABC-Effluxtransporter \u2013 darunter P-gp, BCRP, BSEP und die MRP-Familie \u2013 Resorption, Verteilung und Elimination von Arzneistoffen, indem sie diese an wichtigen biologischen Barrieren aus den Zellen pumpen.<\/p>\n<!-- BUY BOX (SEO: links to buy pages) -->\n<div class=\"sb-buy-box\" style=\"border:1px solid #cfe9e6;background:#f4fbfa;border-radius:12px;padding:22px 26px;margin:28px auto;max-width:1200px;box-sizing:border-box\">\n<h2 style=\"font-size:22px;line-height:1.3;margin:0 0 6px\">ABC-Transporter-Vesikelkits kaufen (aus HEK293)<\/h2>\n<p style=\"margin:0 0 14px\">Angebot f\u00fcr P-gp-, BCRP-, BSEP- und MRP-Vesikelkits f\u00fcr In-vitro-DDI-Studien anfragen.<\/p>\n<ul style=\"margin:0;padding-left:20px;columns:2 300px;column-gap:32px\">\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/p-gp-vesikelkit-mdr1-hek293\/\">P-gp-Vesikelkit (MDR1\/ABCB1)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/bcrp-vesikelkit-abcg2-hek293\/\">BCRP-Vesikelkit (ABCG2)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/bsep-vesikelkit-abcb11-hek293\/\">BSEP-Vesikelkit (ABCB11)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/mrp1-vesikelkit-abcc1-hek293\/\">MRP1-Vesikelkit (ABCC1)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/mrp2-vesikelkit-abcc2-hek293\/\">MRP2-Vesikelkit (ABCC2)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/mrp3-vesikelkit-abcc3-hek293\/\">MRP3-Vesikelkit (ABCC3)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/mrp4-vesikelkit-abcc4-hek293\/\">MRP4-Vesikelkit (ABCC4)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/mrp5-vesikelkit-abcc5-hek293\/\">MRP5-Vesikelkit (ABCC5)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/mrp8-vesikelkit-abcc11-hek293\/\">MRP8-Vesikelkit (ABCC11)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/p-gp-vesikelkit-fluopgp-substrat\/\">P-gp-Vesikelkit mit FluoPgp-Substrat<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/kontroll-vesikelkit-hek293\/\">Kontroll-Vesikelkit (Negativkontrolle)<\/a><\/li>\n<\/ul>\n<p style=\"margin:14px 0 0\"><a href=\"https:\/\/seamlessbio.de\/de\/request-quote\/\" style=\"font-weight:600\">Angebot anfordern \u2192<\/a><\/p>\n<\/div>\n<!-- \/BUY BOX -->\n\n<\/div>\n<!-- SB-BUY-BOX --><div style=\"border:1px solid #daf3f2;border-left:4px solid #18b7b2;background:#f1faf9;border-radius:0 10px 10px 0;padding:14px 18px;margin:18px 0 26px;font-size:15px;line-height:1.6\"><strong>Bereit zu bestellen?<\/strong> <a href=\"https:\/\/seamlessbio.de\/de\/abc-transporter-vesikelkits\/\" style=\"color:#18b7b2;font-weight:700\">ABC-Transporter-Vesikel-Kits \u2013 P-gp, BCRP, BSEP, MRPs \u2192<\/a><br><span style=\"font-size:14px;color:#5b6b71\">Vesikel-Kits f\u00fcr Transporterstudien nach FDA\/EMA\/ICH M12 \u00b7 EU-Lager<\/span><\/div>\n<h2>Wie funktionieren ABC-Transporter?<\/h2>\n<p>ABC-Transporter haben zwei Transmembrandom\u00e4nen (TMD), die den Translokationsweg des Substrats bilden, und zwei Nukleotidbindungsdom\u00e4nen (NBD), die ATP binden und hydrolysieren. Transportzyklus: (1) Das Substrat bindet vom Zytoplasma aus an die nach innen gerichtete TMD; (2) ATP bindet an beide NBD \u2192 Dimerisierung \u2192 die TMD wechseln in die nach au\u00dfen gerichtete Konformation; (3) das Substrat wird nach au\u00dfen abgegeben; (4) ATP-Hydrolyse \u2192 der Transporter kehrt in den Ausgangszustand zur\u00fcck.<\/p>\n<h2>Klinische Bedeutung von ABC-Transporter-DDI<\/h2>\n<p>Die wichtigsten klinischen Beispiele: P-gp-Hemmung durch Ritonavir erh\u00f6ht die AUC von Digoxin um 86 %; duale P-gp\/BCRP-Hemmung durch Eltrombopag verdoppelt die Rosuvastatin-Exposition; BSEP-Hemmung durch Troglitazon verursachte fulminantes Leberversagen und die Marktr\u00fccknahme; P-gp-Induktion durch Rifampicin senkt die Bioverf\u00fcgbarkeit von Digoxin um 30\u201340 %.<\/p>\n<h2>Wichtige Fakten<\/h2>\n<ul>\n<li>ABC = ATP-Binding Cassette \u2013 benannt nach den konservierten Nukleotidbindungsdom\u00e4nen, die ATP hydrolysieren und so den Transport antreiben<\/li>\n<li>Das menschliche Genom kodiert 48 ABC-Transportergene in 7 Unterfamilien (ABCA\u2013ABCG)<\/li>\n<li>Pharmakologisch relevante Effluxtransporter: P-gp (ABCB1), BCRP (ABCG2), BSEP (ABCB11), MRP1\u20138 (ABCC1\u20136, ABCC10\u201311)<\/li>\n<li>Die Lokalisation bestimmt die pharmakokinetische Rolle: Darmepithel (begrenzt die orale Resorption), Blut-Hirn-Schranke (begrenzt die ZNS-Penetration), kanalikul\u00e4re Membran der Hepatozyten (bili\u00e4re Ausscheidung), Nierentubulus (renale Ausscheidung)<\/li>\n<li>ABC-Transporter arbeiten als Effluxpumpen: Das Substrat bindet auf der intrazellul\u00e4ren Seite \u2192 ATP-Hydrolyse \u2192 Konformations\u00e4nderung \u2192 Abgabe des Substrats nach au\u00dfen<\/li>\n<li>FDA, EMA und ICH M12 verlangen f\u00fcr alle NMEs eine In-vitro-Bewertung der Interaktionen mit P-gp, BCRP, BSEP und der MRP-Familie<\/li>\n<\/ul>\n<h2>Weiterlesen<\/h2>\n<ul>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-p-glycoprotein-pgp\/\">Was ist P-Glykoprotein (P-gp)?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-bcrp-abcg2\/\">Was ist BCRP?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-bsep\/\">Was ist BSEP?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-vesicular-transport-assay\/\">Was ist ein vesikul\u00e4rer Transportassay?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/ressourcen\/blog\/inside-out-membrane-vesicles-abc-transporter-explained\/\">Inside-out-Vesikel erkl\u00e4rt<\/a><\/li>\n<\/ul>\n<div style=\"background:#f4f6f7;border-radius:12px;padding:32px;text-align:center;margin-top:40px;\">\n<p style=\"font-size:18px;font-weight:700;color:#1a2e35;margin-bottom:12px;\">Vesikelkit-Portfolio f\u00fcr ABC-Transporter \u2013 Cell4Pharma \u00fcber SeamlessBio<\/p>\n<a href=\"https:\/\/seamlessbio.de\/de\/produkte\/dmpk-transporter-assays\/\" style=\"background:#18b7b2;color:#fff;padding:12px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Zum Produkt \u2192<\/a>\n&nbsp;&nbsp;\n<a href=\"https:\/\/seamlessbio.de\/de\/kontakt\/\" style=\"border:2px solid #18b7b2;color:#139b97;padding:10px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Muster anfordern<\/a>\n<\/div>\n<p style=\"font-size:13px;color:#6b7f82;margin-top:32px;border-top:1px solid #d8e8e7;padding-top:16px;\">\n<em>SeamlessBio \u00b7 Passau, Deutschland \u00b7 <a href=\"mailto:info@seamlessbio.de\">info@seamlessbio.de<\/a><\/em>\n<\/p>\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Quick Definition What is an ABC Transporter?: ATP-binding cassette (ABC) transporters are membrane proteins that use ATP hydrolysis to actively transport substrates across cell membranes against a concentration gradient. In pharmacokinetics, ABC efflux transporters \u2014 including P-gp, BCRP, BSEP, and the MRP family \u2014 control drug absorption, distribution, and elimination by pumping drugs out of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","footnotes":""},"class_list":["post-3038","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ABC Transporters: Function, Types &amp; Drug Interactions<\/title>\n<meta name=\"description\" content=\"How ABC transporters \u2013 P-gp, BCRP, BSEP and MRPs \u2013 pump drugs out of cells, why FDA, EMA and ICH M12 require transporter studies and how vesicle assays test them.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/seamlessbio.de\/de\/what-is-abc-transporter\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ABC Transporters: Function, Types &amp; Drug Interactions\" \/>\n<meta property=\"og:description\" content=\"How ABC transporters \u2013 P-gp, BCRP, BSEP and MRPs \u2013 pump drugs out of cells, why FDA, EMA and ICH M12 require transporter studies and how vesicle assays test them.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/seamlessbio.de\/de\/what-is-abc-transporter\/\" \/>\n<meta property=\"og:site_name\" content=\"SeamlessBio\" \/>\n<meta property=\"article:modified_time\" content=\"2026-11-09T09:19:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/seamlessbio.de\/wp-content\/uploads\/2026\/04\/134428046.png\" \/>\n\t<meta property=\"og:image:width\" content=\"973\" \/>\n\t<meta property=\"og:image:height\" content=\"288\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-abc-transporter\\\/\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-abc-transporter\\\/\",\"name\":\"ABC Transporters: Function, Types & Drug Interactions\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#website\"},\"datePublished\":\"2026-08-22T20:14:16+00:00\",\"dateModified\":\"2026-11-09T09:19:36+00:00\",\"description\":\"How ABC transporters \u2013 P-gp, BCRP, BSEP and MRPs \u2013 pump drugs out of cells, why FDA, EMA and ICH M12 require transporter studies and how vesicle assays test them.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-abc-transporter\\\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/seamlessbio.de\\\/what-is-abc-transporter\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-abc-transporter\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Start\",\"item\":\"https:\\\/\\\/seamlessbio.de\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"What is an ABC Transporter?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#website\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/\",\"name\":\"SeamlessBio\",\"description\":\"Human serum, plasma and hPL, single-use bioprocessing bags, serum-free media, animal sera and FBS. 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