{"id":3048,"date":"2026-08-22T21:15:40","date_gmt":"2026-08-22T20:15:40","guid":{"rendered":"https:\/\/wheat-quail-856400.hostingersite.com\/?page_id=3048"},"modified":"2026-11-02T16:24:49","modified_gmt":"2026-11-02T15:24:49","slug":"what-is-adme","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/what-is-adme\/","title":{"rendered":"Was ist ADME?"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"3048\" class=\"elementor elementor-3048\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-49e15f2 e-con e-atomic-element e-flexbox-base e-default-div e-4e66028\" data-id=\"49e15f2\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"49e15f2\">\n    \t\t<div class=\"elementor-element elementor-element-03ab325 elementor-widget elementor-widget-html\" data-id=\"03ab325\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- \nWORDPRESS PAGE \u2014 GUTENBERG \"BENUTZERDEFINIERTES HTML\" BLOCK\nSlug: what-is-adme\nSEO Title: What is ADME? \u2014 Definition in Drug Development | SeamlessBio\nMeta Description: What is ADME (absorption, distribution, metabolism, excretion) in drug development, why is ADME profiling required, and how is each component assessed in vitro?\nFocus Keyword: what is ADME drug development\nAdditional Keywords: ADME pharmacokinetics definition, absorption distribution metabolism excretion, ADME in vitro assays DMPK\nMenu: Resources \u2192 Glossary\n-->\n<div style=\"background:#e9fbfa;border-left:4px solid #18b7b2;border-radius:0 8px 8px 0;padding:20px 24px;margin-bottom:32px;\">\n<p style=\"font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:1px;color:#139b97;margin-bottom:8px;\">Kurzdefinition<\/p>\n<p style=\"font-size:16px;margin:0;\"><strong>Was ist ADME?:<\/strong> ADME steht f\u00fcr Absorption, Distribution, Metabolismus und Exkretion \u2013 die vier pharmakokinetischen Prozesse, die den Weg eines Arzneimittels durch den K\u00f6rper von der Gabe bis zur Elimination bestimmen. Das ADME-Profiling ist ein zentraler Teil der pr\u00e4klinischen Wirkstoffentwicklung: Es sagt aus In-vitro-Daten das pharmakokinetische Verhalten in vivo voraus und steuert die Auswahl der Wirkstoffkandidaten.<\/p>\n<\/div>\n<h2>Warum ADME-Profiling wichtig ist<\/h2>\n<p>Ein Wirkstoff mit hervorragender Wirkst\u00e4rke am Zielmolek\u00fcl scheitert in der klinischen Entwicklung, wenn er schnell abgebaut (kurze Halbwertszeit), schlecht resorbiert (geringe orale Bioverf\u00fcgbarkeit) oder durch reaktive Metaboliten toxisch wird. Das ADME-Profiling erkennt diese Schwachstellen fr\u00fch in der Discovery, sodass die medizinische Chemie sie vor teuren klinischen Investitionen beheben kann.<\/p>\n<h2>ADME und Zulassungsantr\u00e4ge<\/h2>\n<p>FDA, EMA und ICH M12 verlangen in IND-erm\u00f6glichenden Studien ein vollst\u00e4ndiges In-vitro-ADME-Paket: metabolische Stabilit\u00e4t, Reaktionsph\u00e4notypisierung, CYP-Inhibition\/-Induktion, Plasmaproteinbindung und Transporter-DDI-Bewertung. SeamlessBio liefert die biologischen Werkzeuge: ABC-Transporter-Vesikel-Kits sowie humanes AB-Serum\/-Plasma f\u00fcr Proteinbindungsassays.<\/p>\n<h2>Wichtige Fakten<\/h2>\n<ul>\n<li>A: Absorption \u2013 wie der Wirkstoff in den Blutkreislauf gelangt; bestimmt durch L\u00f6slichkeit, Permeabilit\u00e4t und die Aktivit\u00e4t von Efflux-Transportern (P-gp, BCRP) in der Darmwand<\/li>\n<li>D: Distribution \u2013 wie sich der Wirkstoff im Gewebe verteilt; bestimmt durch Plasmaproteinbindung (fu,plasma), Lipophilie (logP) und die Transporterexpression im Gewebe<\/li>\n<li>M: Metabolismus \u2013 chemische Umwandlung durch hepatische CYP450-Enzyme (CYP3A4, 2D6, 2C9, 2C19, 1A2) und Phase-II-Enzyme (UGTs, SULTs)<\/li>\n<li>E: Exkretion \u2013 Ausscheidung \u00fcber die Niere (OCT2, OAT1\/3, MATE1\/2-K) und die Galle (BSEP, MRP2, P-gp)<\/li>\n<li>ADME-Profiling senkt die Ausfallquote in sp\u00e4ten Phasen \u2013 in den 1990er-Jahren scheiterten ~40 % der klinischen Kandidaten an ung\u00fcnstigem ADME<\/li>\n<li>Wichtige In-vitro-Assays: Caco-2\/PAMPA (Permeabilit\u00e4t), Plasmaproteinbindung (fu), mikrosomale Stabilit\u00e4t, Hepatozyten-Clearance, Transporter-DDI<\/li>\n<\/ul>\n<h2>Weiterlesen<\/h2>\n<ul>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-drug-drug-interaction-ddi\/\">Was ist eine DDI?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/ressourcen\/blog\/in-vitro-drug-metabolism-cyp450-microsomes-hepatocytes\/\">Leitfaden In-vitro-Wirkstoffmetabolismus<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/ressourcen\/blog\/fda-ema-mandatory-drug-transporters-ind-dmpk-guide\/\">Verpflichtende Transporter nach FDA &amp; EMA<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-abc-transporter\/\">Was ist ein ABC-Transporter?<\/a><\/li>\n<\/ul>\n<div style=\"background:#f4f6f7;border-radius:12px;padding:32px;text-align:center;margin-top:40px;\">\n<p style=\"font-size:18px;font-weight:700;color:#1a2e35;margin-bottom:12px;\">Werkzeuge f\u00fcr DMPK-Assays \u2013 Transporter-Kits &amp; Humanserum | SeamlessBio<\/p>\n<a href=\"https:\/\/seamlessbio.de\/de\/produkte\/dmpk-transporter-assays\/\" style=\"background:#18b7b2;color:#fff;padding:12px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Zum Produkt \u2192<\/a>\n&nbsp;&nbsp;\n<a href=\"https:\/\/seamlessbio.de\/de\/kontakt\/\" style=\"border:2px solid #18b7b2;color:#139b97;padding:10px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Muster anfordern<\/a>\n<\/div>\n<p style=\"font-size:13px;color:#6b7f82;margin-top:32px;border-top:1px solid #d8e8e7;padding-top:16px;\">\n<em>SeamlessBio \u00b7 Passau, Deutschland \u00b7 <a href=\"mailto:info@seamlessbio.de\">info@seamlessbio.de<\/a><\/em>\n<\/p>\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Quick Definition What is ADME?: ADME stands for Absorption, Distribution, Metabolism, and Excretion \u2014 the four pharmacokinetic processes that determine a drug&#8217;s journey through the body from administration to elimination. ADME profiling is a central part of preclinical drug development that predicts in vivo pharmacokinetic behaviour from in vitro assay data and guides drug candidate [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","footnotes":""},"class_list":["post-3048","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is ADME? \u2014 Definition in Drug Development | SeamlessBio<\/title>\n<meta name=\"description\" content=\"What is ADME (absorption, distribution, metabolism, excretion) in drug development, why is ADME profiling required, and how is each component assessed in vitro?\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/seamlessbio.de\/de\/what-is-adme\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is ADME? \u2014 Definition in Drug Development | SeamlessBio\" \/>\n<meta property=\"og:description\" content=\"What is ADME (absorption, distribution, metabolism, excretion) in drug development, why is ADME profiling required, and how is each component assessed in vitro?\" \/>\n<meta property=\"og:url\" content=\"https:\/\/seamlessbio.de\/de\/what-is-adme\/\" \/>\n<meta property=\"og:site_name\" content=\"SeamlessBio\" \/>\n<meta property=\"article:modified_time\" content=\"2026-11-02T15:24:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/seamlessbio.de\/wp-content\/uploads\/2026\/04\/134428046.png\" \/>\n\t<meta property=\"og:image:width\" content=\"973\" \/>\n\t<meta property=\"og:image:height\" content=\"288\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-adme\\\/\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-adme\\\/\",\"name\":\"What is ADME? \u2014 Definition in Drug Development | SeamlessBio\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#website\"},\"datePublished\":\"2026-08-22T20:15:40+00:00\",\"dateModified\":\"2026-11-02T15:24:49+00:00\",\"description\":\"What is ADME (absorption, distribution, metabolism, excretion) in drug development, why is ADME profiling required, and how is each component assessed in vitro?\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-adme\\\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/seamlessbio.de\\\/what-is-adme\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-adme\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Start\",\"item\":\"https:\\\/\\\/seamlessbio.de\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"What is ADME?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#website\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/\",\"name\":\"SeamlessBio\",\"description\":\"Human serum, plasma and hPL, single-use bioprocessing bags, serum-free media, animal sera and FBS. 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