{"id":3053,"date":"2026-08-22T21:16:16","date_gmt":"2026-08-22T20:16:16","guid":{"rendered":"https:\/\/seamlessbio.de\/?page_id=3053"},"modified":"2026-08-23T00:13:08","modified_gmt":"2026-08-22T23:13:08","slug":"what-is-ciptec-renal-transporter","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/what-is-ciptec-renal-transporter\/","title":{"rendered":"What is ciPTEC?"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"3053\" class=\"elementor elementor-3053\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-087895b e-con e-atomic-element e-flexbox-base e-df185c6\" data-id=\"087895b\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"087895b\">\n    \t\t<div class=\"elementor-element elementor-element-3a09d87 elementor-widget elementor-widget-html\" data-id=\"3a09d87\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- \nWORDPRESS PAGE \u2014 GUTENBERG \"BENUTZERDEFINIERTES HTML\" BLOCK\nSlug: what-is-ciptec-renal-transporter\nSEO Title: What is ciPTEC? \u2014 Renal Transporter Cell Model | SeamlessBio\nMeta Description: What is ciPTEC (conditionally immortalised proximal tubule epithelial cells), why it expresses OAT1 and OAT3, and when to use it over HK-2 for renal DDI.\nFocus Keyword: what is ciPTEC renal transporter cell model\nAdditional Keywords: ciPTEC OAT1 OAT3 OCT2 renal transporter, ciPTEC vs HK-2 renal DDI, conditionally immortalised proximal tubule cells\nMenu: Resources \u2192 Glossary\n-->\n<div style=\"background:#e9fbfa;border-left:4px solid #18b7b2;border-radius:0 8px 8px 0;padding:20px 24px;margin-bottom:32px;\">\n<p style=\"font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:1px;color:#139b97;margin-bottom:8px;\">Quick Definition<\/p>\n<p style=\"font-size:16px;margin:0;\"><strong>What is ciPTEC?:<\/strong> ciPTEC (conditionally immortalised proximal tubule epithelial cells) are human renal proximal tubule cells immortalised using a temperature-sensitive SV40 large T antigen. ciPTEC stably express OAT1, OAT3, and OCT2 \u2014 the three renal uptake transporters for most renally-cleared drugs \u2014 making them the most physiologically relevant in vitro model for renal DDI assessment under ICH M12.<\/p>\n<\/div>\n<h2>Why ciPTEC instead of HK-2?<\/h2>\n<p>HK-2 cells do not express OAT1 (SLC22A6) or OAT3 (SLC22A8) \u2014 the two proximal tubule transporters responsible for uptake of most organic anions. Using HK-2 for OAT1\/OAT3 studies produces artifactual results with no physiological relevance. ciPTEC expresses both OAT1 and OAT3 endogenously and has been validated against clinical reference drugs (probenecid\/furosemide OAT1, probenecid\/cimetidine OAT3).<\/p>\n<h2>ciPTEC under ICH M12<\/h2>\n<p>ICH M12 requires assessment of OCT2, OAT1 and OAT3 for all NMEs with renal elimination. ciPTEC covers all three transporters plus additional efflux transporters (MRP4, P-gp, MATE1\/2-K) \u2014 providing complete proximal tubule secretion pathway coverage in a single cell model.<\/p>\n<h2>Key Facts<\/h2>\n<ul>\n<li>Derived from human urine \u2014 retains proximal tubule epithelial cell characteristics<\/li>\n<li>Stably expresses: OAT1 (SLC22A6), OAT3 (SLC22A8), OCT2 (SLC22A2), MRP4, P-gp, MATE1\/2-K<\/li>\n<li>Validated in &gt;90 peer-reviewed publications including studies from AstraZeneca, Roche, and Pfizer<\/li>\n<li>HK-2 (most common alternative) does NOT express OAT1 or OAT3 \u2014 the primary transporters for anionic drug secretion<\/li>\n<li>Available from SeamlessBio Switzerland (seamlessbio.ch) for DACH customers<\/li>\n<li>Used under ICH M12 guidance for OCT2, OAT1, OAT3 substrate and inhibitor studies<\/li>\n<\/ul>\n<h2>Further Reading<\/h2>\n<ul>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-drug-drug-interaction-ddi\/\">What is DDI?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/ressourcen\/blog\/fda-ema-mandatory-drug-transporters-ind-dmpk-guide\/\">FDA & EMA Mandatory Transporters for IND<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-abc-transporter\/\">What is ABC Transporter?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/produkte\/dmpk-transporter-assays\/\">DMPK Kit Portfolio<\/a><\/li>\n<\/ul>\n<div style=\"background:#f4f6f7;border-radius:12px;padding:32px;text-align:center;margin-top:40px;\">\n<p style=\"font-size:18px;font-weight:700;color:#1a2e35;margin-bottom:12px;\">ciPTEC \u2014 Renal Transporter Model via SeamlessBio Switzerland<\/p>\n<a href=\"https:\/\/seamlessbio.ch\/ciptec-renale-transporter\/\" style=\"background:#18b7b2;color:#fff;padding:12px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">View Product \u2192<\/a>\n&nbsp;&nbsp;\n<a href=\"https:\/\/seamlessbio.de\/de\/kontakt\/\" style=\"border:2px solid #18b7b2;color:#139b97;padding:10px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Muster anfordern<\/a>\n<\/div>\n<p style=\"font-size:13px;color:#6b7f82;margin-top:32px;border-top:1px solid #d8e8e7;padding-top:16px;\">\n<em>SeamlessBio GmbH \u00b7 Passau, Germany \u00b7 <a href=\"mailto:info@seamlessbio.de\">info@seamlessbio.de<\/a><\/em>\n<\/p>\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Quick Definition What is ciPTEC?: ciPTEC (conditionally immortalised proximal tubule epithelial cells) are human renal proximal tubule cells immortalised using a temperature-sensitive SV40 large T antigen. ciPTEC stably express OAT1, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_eb_attr":"","footnotes":""},"class_list":["post-3053","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is ciPTEC? 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