{"id":3098,"date":"2026-08-22T21:24:01","date_gmt":"2026-08-22T20:24:01","guid":{"rendered":"https:\/\/wheat-quail-856400.hostingersite.com\/?page_id=3098"},"modified":"2026-11-12T18:43:44","modified_gmt":"2026-11-12T17:43:44","slug":"what-is-chemically-defined-medium","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/what-is-chemically-defined-medium\/","title":{"rendered":"Was ist ein chemisch definiertes Medium?"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"3098\" class=\"elementor elementor-3098\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f627c9 e-con e-atomic-element e-flexbox-base e-default-div e-2958c0c\" data-id=\"7f627c9\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"7f627c9\">\n    \t\t<div class=\"elementor-element elementor-element-93541b1 elementor-widget elementor-widget-html\" data-id=\"93541b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- \nWORDPRESS PAGE \u2014 GUTENBERG \"BENUTZERDEFINIERTES HTML\" BLOCK\nSlug: what-is-chemically-defined-medium\nSEO Title: What is Chemically Defined Medium? \u2014 Cell Culture Definition | SeamlessBio\nMeta Description: What is chemically defined cell culture medium, how does it differ from serum-containing and serum-free media, and when is it required for GMP manufacturing?\nFocus Keyword: what is chemically defined medium cell culture\nAdditional Keywords: chemically defined medium GMP ATMP, CDM cell culture definition, chemically defined vs serum free medium\nMenu: Resources \u2192 Glossary\n-->\n<div style=\"background:#e9fbfa;border-left:4px solid #18b7b2;border-radius:0 8px 8px 0;padding:20px 24px;margin-bottom:32px;\">\n<p style=\"font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:1px;color:#139b97;margin-bottom:8px;\">Kurzdefinition<\/p>\n<p style=\"font-size:16px;margin:0;\"><strong>Was ist chemisch definiertes Medium (CDM)?:<\/strong> Chemisch definiertes Medium (CDM) ist ein Zellkulturmedium, in dem jede Komponente eine aufgereinigte, identifizierte chemische Substanz mit bekannter Molek\u00fclstruktur und Konzentration ist. Undefinierte biologische Gemische \u2013 etwa Serum, Proteinhydrolysate, Hefeextrakt oder Gewebeextrakte \u2013 sind nicht enthalten. CDM bietet maximale Reproduzierbarkeit und ist der regulatorische Goldstandard f\u00fcr die GMP-Herstellung von Biopharmazeutika.<\/p>\n<!-- BUY BOX (SEO: links to buy pages) -->\n<div class=\"sb-buy-box\" style=\"border:1px solid #cfe9e6;background:#f4fbfa;border-radius:12px;padding:22px 26px;margin:28px auto;max-width:1200px;box-sizing:border-box\">\n<h2 style=\"font-size:22px;line-height:1.3;margin:0 0 6px\">Serumfreie Zellkulturmedien ab EU-Lager kaufen<\/h2>\n<p style=\"margin:0 0 14px\">Angebot oder Testmuster anfragen \u2013 keine Mindestbestellmenge, Angebot innerhalb von 48 Stunden.<\/p>\n<ul style=\"margin:0;padding-left:20px;columns:2 300px;column-gap:32px\">\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/simplacex-serumfreies-medium-hek293t\/\">SimplaceX \u2013 serumfreies HEK293T-Medium<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/simplacecdx-chemisch-definiertes-medium-hek293t\/\">SimplaceCDX \u2013 chemisch definiertes HEK293T-Medium<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/naivacore-naives-ipsc-medium-hensm\/\">NaivaCore \u2013 naives iPSC-Medium (HENSM)<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/serumfreies-medium-cho\/\">Serumfreie CHO-Zellkulturmedien<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/cellimax-metacho-cd-cho-basalmedium\/\">CelliMax\u00ae MetaCHO &amp; Versa \u2013 CHO-Basalmedien<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/produkt\/cellimax-cho-fga-feedmedium\/\">CelliMax\u00ae CHO-Feeds \u2013 FGa, FGa plus, FGb<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/serumfreies-msc-medium-gmp\/\">Serumfreies MSC-Medium<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/serumfreies-ipsc-medium-gmp\/\">Serumfreies iPSC- &amp; hESC-Medium<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/anwendungen\/organoid-3d-cell-culture\/\">OrganoMedium \u2013 Medium f\u00fcr die Organoid-Expansion<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/de\/massgeschneiderte-zellkulturmedien\/\">Ma\u00dfgeschneiderte Zellkulturmedien \u2013 individuelle Formulierung<\/a><\/li>\n<\/ul>\n<p style=\"margin:14px 0 0\"><a href=\"https:\/\/seamlessbio.de\/de\/request-quote\/\" style=\"font-weight:600\">Angebot anfordern \u2192<\/a><\/p>\n<\/div>\n<!-- \/BUY BOX -->\n\n<\/div>\n<h2>Warum chemisch definiertes Medium regulatorisch bevorzugt wird<\/h2>\n<p>Undefinierte Rohstoffe (Serum, Hydrolysate) bringen schwer kontrollierbare Schwankungen mit. Chargenunterschiede bei FKS k\u00f6nnen Zellwachstum, Produktivit\u00e4t und Produktqualit\u00e4t (Glykosylierung, Ladungsvarianten) verschieben \u2013 und erfordern bei jeder neuen Charge eine erneute Qualifizierung. CDM beseitigt diese Variabilit\u00e4t, weil jede Komponente definiert ist und gleichbleibend geliefert wird. Deshalb ist CDM f\u00fcr alle zugelassenen biopharmazeutischen Herstellungsprozesse die regulatorisch bevorzugte Wahl.<\/p>\n<h2>CDM f\u00fcr die CHO- und HEK293-Produktion<\/h2>\n<p>Die Biopharma-Industrie hat die CHO-basierte mAk-Produktion weitgehend auf CDM umgestellt. F\u00fcr die HEK293-basierte Produktion von AAV- und Lentivirusvektoren gibt es mehrere CDM-Optionen. SeamlessBio unterst\u00fctzt CDM-Formulierungen mit rHSA und OsrhTF als ACF-Quellen f\u00fcr Albumin und Transferrin.<\/p>\n<h2>Wichtige Fakten<\/h2>\n<ul>\n<li>Jede Komponente ist chemisch identifiziert \u2013 mit CAS-Nummer, Summenformel und definierter Konzentration<\/li>\n<li>Schlie\u00dft aus: FKS, Humanserum, hPL, Proteinhydrolysate, Hefeextrakt, Sojaextrakt \u2013 alle undefinierten biologischen Gemische<\/li>\n<li>Schlie\u00dft ein: Aminos\u00e4uren, Vitamine, anorganische Salze, aufgereinigte rekombinante Proteine (sofern vollst\u00e4ndig charakterisiert), synthetische Lipide, Glukose<\/li>\n<li>Rekombinante Proteine (rHSA, OsrhTF, rekombinantes Insulin, rekombinante Wachstumsfaktoren) gelten als chemisch definiert, wenn sie vollst\u00e4ndig charakterisiert sind<\/li>\n<li>Eingesetzt in: CHO-Zellkultur f\u00fcr die mAk-Produktion, HEK293-Suspension f\u00fcr virale Vektoren, iPSC-Erhaltung<\/li>\n<li>CDM erfordert Chargenkonstanz \u2013 gesteuert \u00fcber das CoA jeder Komponente und des fertigen Mediums<\/li>\n<\/ul>\n<h2>Weiterlesen<\/h2>\n<ul>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-serum-free-medium\/\">Was ist serumfreies Medium?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-animal-component-free-acf\/\">Was ist tierkomponentenfrei?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/ressourcen\/guides\/anpassung-an-die-serumfreie-zellkultur\/\">Protokoll zur serumfreien Adaptation<\/a><\/li>\n<\/ul>\n<div style=\"background:#f4f6f7;border-radius:12px;padding:32px;text-align:center;margin-top:40px;\">\n<p style=\"font-size:18px;font-weight:700;color:#1a2e35;margin-bottom:12px;\">CDM-Komponenten \u2013 rHSA &amp; OsrhTF | SeamlessBio<\/p>\n<a href=\"https:\/\/seamlessbio.de\/de\/produkte\/albuminproteine\/\" style=\"background:#18b7b2;color:#fff;padding:12px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Zum Produkt \u2192<\/a>\n&nbsp;&nbsp;\n<a href=\"https:\/\/seamlessbio.de\/de\/kontakt\/\" style=\"border:2px solid #18b7b2;color:#139b97;padding:10px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Muster anfordern<\/a>\n<\/div>\n<p style=\"font-size:13px;color:#6b7f82;margin-top:32px;border-top:1px solid #d8e8e7;padding-top:16px;\">\n<em>SeamlessBio \u00b7 Passau, Deutschland \u00b7 <a href=\"mailto:info@seamlessbio.de\">info@seamlessbio.de<\/a><\/em>\n<\/p>\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Quick Definition What is Chemically Defined Medium (CDM)?: Chemically defined medium (CDM) is cell culture medium where every component is a purified, identified chemical entity with a known molecular structure and concentration. No undefined biological mixtures \u2014 such as serum, protein hydrolysates, yeast extract, or tissue extracts \u2014 are present. CDM provides maximum reproducibility and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","footnotes":""},"class_list":["post-3098","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is Chemically Defined Medium? \u2014 Cell Culture Definition | SeamlessBio<\/title>\n<meta name=\"description\" content=\"What is chemically defined cell culture medium, how does it differ from serum-containing and serum-free media, and when is it required for GMP manufacturing?\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/seamlessbio.de\/de\/what-is-chemically-defined-medium\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is Chemically Defined Medium? \u2014 Cell Culture Definition | SeamlessBio\" \/>\n<meta property=\"og:description\" content=\"What is chemically defined cell culture medium, how does it differ from serum-containing and serum-free media, and when is it required for GMP manufacturing?\" \/>\n<meta property=\"og:url\" content=\"https:\/\/seamlessbio.de\/de\/what-is-chemically-defined-medium\/\" \/>\n<meta property=\"og:site_name\" content=\"SeamlessBio\" \/>\n<meta property=\"article:modified_time\" content=\"2026-11-12T17:43:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/seamlessbio.de\/wp-content\/uploads\/2026\/04\/134428046.png\" \/>\n\t<meta property=\"og:image:width\" content=\"973\" \/>\n\t<meta property=\"og:image:height\" content=\"288\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-chemically-defined-medium\\\/\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-chemically-defined-medium\\\/\",\"name\":\"What is Chemically Defined Medium? \u2014 Cell Culture Definition | SeamlessBio\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#website\"},\"datePublished\":\"2026-08-22T20:24:01+00:00\",\"dateModified\":\"2026-11-12T17:43:44+00:00\",\"description\":\"What is chemically defined cell culture medium, how does it differ from serum-containing and serum-free media, and when is it required for GMP manufacturing?\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-chemically-defined-medium\\\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/seamlessbio.de\\\/what-is-chemically-defined-medium\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-chemically-defined-medium\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Start\",\"item\":\"https:\\\/\\\/seamlessbio.de\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"What is Chemically Defined Medium?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#website\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/\",\"name\":\"SeamlessBio\",\"description\":\"Human serum, plasma and hPL, single-use bioprocessing bags, serum-free media, animal sera and FBS. 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