{"id":3108,"date":"2026-08-22T21:33:08","date_gmt":"2026-08-22T20:33:08","guid":{"rendered":"https:\/\/wheat-quail-856400.hostingersite.com\/?page_id=3108"},"modified":"2026-11-02T16:24:24","modified_gmt":"2026-11-02T15:24:24","slug":"what-is-msc-mesenchymal-stem-cell","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/what-is-msc-mesenchymal-stem-cell\/","title":{"rendered":"Was ist eine MSC (mesenchymale Stammzelle)?"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"3108\" class=\"elementor elementor-3108\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cc92681 e-con e-atomic-element e-flexbox-base e-default-div e-7f643e7\" data-id=\"cc92681\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"cc92681\">\n    \t\t<div class=\"elementor-element elementor-element-39bf2e5 elementor-widget elementor-widget-html\" data-id=\"39bf2e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- \nWORDPRESS PAGE \u2014 GUTENBERG \"BENUTZERDEFINIERTES HTML\" BLOCK\nSlug: what-is-msc-mesenchymal-stem-cell\nSEO Title: What is an MSC (Mesenchymal Stem Cell)? \u2014 Definition | SeamlessBio\nMeta Description: What is a mesenchymal stem cell (MSC), where do MSCs come from, what do they do, and what serum is used for MSC expansion in cell therapy?\nFocus Keyword: what is MSC mesenchymal stem cell\nAdditional Keywords: mesenchymal stem cell definition culture medium, MSC expansion hPL FBS, MSC cell therapy ATMP\nMenu: Resources \u2192 Glossary\n-->\n<div style=\"background:#e9fbfa;border-left:4px solid #18b7b2;border-radius:0 8px 8px 0;padding:20px 24px;margin-bottom:32px;\">\n<p style=\"font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:1px;color:#139b97;margin-bottom:8px;\">Kurzdefinition<\/p>\n<p style=\"font-size:16px;margin:0;\"><strong>Was ist eine MSC (mesenchymale Stammzelle)?:<\/strong> Mesenchymale Stammzellen (MSCs), auch mesenchymale Stromazellen genannt, sind multipotente adulte Stammzellen aus Knochenmark, Fettgewebe, Nabelschnur und anderen Geweben. Sie k\u00f6nnen sich zu Osteoblasten, Chondrozyten und Adipozyten differenzieren und besitzen ausgepr\u00e4gte immunmodulatorische Eigenschaften \u2013 damit sind sie der klinisch am intensivsten untersuchte Zelltyp in Regenerativmedizin und Zelltherapie.<\/p>\n<\/div>\n<h2>FKS vs. hPL f\u00fcr die MSC-Expansion<\/h2>\n<p>Mehrere ver\u00f6ffentlichte Studien zum Vergleich von FKS und hPL bei der MSC-Expansion kommen \u00fcbereinstimmend zu dem Ergebnis: hPL mit 5 % unterst\u00fctzt h\u00f6here Proliferationsraten (k\u00fcrzere Populationsverdopplungszeit), erh\u00e4lt die ISCT-Immunph\u00e4notyp-Kriterien gleich gut oder besser und zeigt oft eine \u00fcberlegene immunmodulatorische Wirksamkeit. F\u00fcr die MSC-Herstellung in klinischer Qualit\u00e4t ist hPL nach den ATMP-Leitlinien der EMA der bevorzugte Zusatz, weil es keine bovinen Proteine einbringt und in GMP-Qualit\u00e4t mit vollst\u00e4ndiger Spenderdokumentation verf\u00fcgbar ist.<\/p>\n<h2>Klinische Anwendungen von MSCs<\/h2>\n<p>MSCs werden in klinischen Studien untersucht bei: GvHD, Morbus Crohn, ARDS, COVID-19-Pneumonie, Arthrose, Myokardinfarkt und ALS. Allogene MSC-Produkte k\u00f6nnen oft ohne HLA-Abgleich verabreicht werden \u2013 das erm\u00f6glicht eine Off-the-Shelf-Herstellung.<\/p>\n<h2>Wichtige Fakten<\/h2>\n<ul>\n<li>ISCT-Kriterien: plastikadh\u00e4rent; exprimieren CD73, CD90, CD105; ohne CD34, CD45, CD14, HLA-DR; differenzieren zu Osteoblasten, Chondrozyten, Adipozyten<\/li>\n<li>Quellen: Knochenmark (BM-MSC), Fettgewebe (AT-MSC), Nabelschnur (UC-MSC, Wharton-Sulze-MSC), Zahnpulpa, Plazenta<\/li>\n<li>Immunmodulatorisch: hemmen die T-Zell-Proliferation, verringern die NK-Zytotoxizit\u00e4t, polarisieren Makrophagen Richtung M2 \u2013 \u00fcber PGE2, IDO, TGF-\u03b2, IL-10<\/li>\n<li>Standard-Expansion: DMEM oder \u03b1-MEM + 10 % FKS (Forschung) oder 5 % hPL (klinische Qualit\u00e4t, xenofrei)<\/li>\n<li>hPL mit 5 % \u00fcbertrifft FKS mit 10 % bei der MSC-Proliferation in den meisten ver\u00f6ffentlichten Studien \u2013 empfohlen f\u00fcr die Expansion in klinischer Qualit\u00e4t<\/li>\n<li>Passagegrenze: Klinische Protokolle verwenden MSCs meist bis Passage 5\u20138, um die Wirksamkeit zu erhalten<\/li>\n<\/ul>\n<h2>Weiterlesen<\/h2>\n<ul>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-human-platelet-lysate-hpl\/\">Was ist hPL?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-atmp\/\">Was ist ein ATMP?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-xeno-free-cell-culture\/\">Was ist eine xeno-freie Zellkultur?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/ressourcen\/blog\/human-platelet-lysate-hpl-fbs-replacement-guide\/\">hPL \u2013 der vollst\u00e4ndige Leitfaden<\/a><\/li>\n<\/ul>\n<div style=\"background:#f4f6f7;border-radius:12px;padding:32px;text-align:center;margin-top:40px;\">\n<p style=\"font-size:18px;font-weight:700;color:#1a2e35;margin-bottom:12px;\">hPL &amp; FKS f\u00fcr die MSC-Expansion \u2013 SeamlessBio<\/p>\n<a href=\"https:\/\/seamlessbio.de\/de\/produkte\/humanserum\/\" style=\"background:#18b7b2;color:#fff;padding:12px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Zum Produkt \u2192<\/a>\n&nbsp;&nbsp;\n<a href=\"https:\/\/seamlessbio.de\/de\/kontakt\/\" style=\"border:2px solid #18b7b2;color:#139b97;padding:10px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Muster anfordern<\/a>\n<\/div>\n<p style=\"font-size:13px;color:#6b7f82;margin-top:32px;border-top:1px solid #d8e8e7;padding-top:16px;\">\n<em>SeamlessBio \u00b7 Passau, Deutschland \u00b7 <a href=\"mailto:info@seamlessbio.de\">info@seamlessbio.de<\/a><\/em>\n<\/p>\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Quick Definition What is an MSC (Mesenchymal Stem Cell)?: Mesenchymal stem cells (MSCs), also called mesenchymal stromal cells, are multipotent adult stem cells found in bone marrow, adipose tissue, umbilical cord, and other tissues. They can differentiate into osteoblasts, chondrocytes, and adipocytes, and have potent immunomodulatory properties \u2014 making them the most clinically investigated cell [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","footnotes":""},"class_list":["post-3108","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is an MSC (Mesenchymal Stem Cell)? \u2014 Definition<\/title>\n<meta name=\"description\" content=\"What is a mesenchymal stem cell (MSC), where do MSCs come from, what do they do, and what serum is used for MSC expansion in cell therapy?\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/seamlessbio.de\/de\/what-is-msc-mesenchymal-stem-cell\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is an MSC (Mesenchymal Stem Cell)? \u2014 Definition\" \/>\n<meta property=\"og:description\" content=\"What is a mesenchymal stem cell (MSC), where do MSCs come from, what do they do, and what serum is used for MSC expansion in cell therapy?\" \/>\n<meta property=\"og:url\" content=\"https:\/\/seamlessbio.de\/de\/what-is-msc-mesenchymal-stem-cell\/\" \/>\n<meta property=\"og:site_name\" content=\"SeamlessBio\" \/>\n<meta property=\"article:modified_time\" content=\"2026-11-02T15:24:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/seamlessbio.de\/wp-content\/uploads\/2026\/04\/134428046.png\" \/>\n\t<meta property=\"og:image:width\" content=\"973\" \/>\n\t<meta property=\"og:image:height\" content=\"288\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-msc-mesenchymal-stem-cell\\\/\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-msc-mesenchymal-stem-cell\\\/\",\"name\":\"What is an MSC (Mesenchymal Stem Cell)? \u2014 Definition\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#website\"},\"datePublished\":\"2026-08-22T20:33:08+00:00\",\"dateModified\":\"2026-11-02T15:24:24+00:00\",\"description\":\"What is a mesenchymal stem cell (MSC), where do MSCs come from, what do they do, and what serum is used for MSC expansion in cell therapy?\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-msc-mesenchymal-stem-cell\\\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/seamlessbio.de\\\/what-is-msc-mesenchymal-stem-cell\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/what-is-msc-mesenchymal-stem-cell\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Start\",\"item\":\"https:\\\/\\\/seamlessbio.de\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"What is an MSC (Mesenchymal Stem Cell)?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#website\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/\",\"name\":\"SeamlessBio\",\"description\":\"Human serum, plasma and hPL, single-use bioprocessing bags, serum-free media, animal sera and FBS. 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