{"id":3108,"date":"2026-08-22T21:33:08","date_gmt":"2026-08-22T20:33:08","guid":{"rendered":"https:\/\/seamlessbio.de\/?page_id=3108"},"modified":"2026-08-22T23:49:25","modified_gmt":"2026-08-22T22:49:25","slug":"what-is-msc-mesenchymal-stem-cell","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/what-is-msc-mesenchymal-stem-cell\/","title":{"rendered":"What is an MSC (Mesenchymal Stem Cell)?"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"3108\" class=\"elementor elementor-3108\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cc92681 e-con e-atomic-element e-flexbox-base e-7f643e7\" data-id=\"cc92681\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"cc92681\">\n    \t\t<div class=\"elementor-element elementor-element-39bf2e5 elementor-widget elementor-widget-html\" data-id=\"39bf2e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- \nWORDPRESS PAGE \u2014 GUTENBERG \"BENUTZERDEFINIERTES HTML\" BLOCK\nSlug: what-is-msc-mesenchymal-stem-cell\nSEO Title: What is an MSC (Mesenchymal Stem Cell)? \u2014 Definition | SeamlessBio\nMeta Description: What is a mesenchymal stem cell (MSC), where do MSCs come from, what do they do, and what serum is used for MSC expansion in cell therapy?\nFocus Keyword: what is MSC mesenchymal stem cell\nAdditional Keywords: mesenchymal stem cell definition culture medium, MSC expansion hPL FBS, MSC cell therapy ATMP\nMenu: Resources \u2192 Glossary\n-->\n<div style=\"background:#e9fbfa;border-left:4px solid #18b7b2;border-radius:0 8px 8px 0;padding:20px 24px;margin-bottom:32px;\">\n<p style=\"font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:1px;color:#139b97;margin-bottom:8px;\">Quick Definition<\/p>\n<p style=\"font-size:16px;margin:0;\"><strong>What is an MSC (Mesenchymal Stem Cell)?:<\/strong> Mesenchymal stem cells (MSCs), also called mesenchymal stromal cells, are multipotent adult stem cells found in bone marrow, adipose tissue, umbilical cord, and other tissues. They can differentiate into osteoblasts, chondrocytes, and adipocytes, and have potent immunomodulatory properties \u2014 making them the most clinically investigated cell type in regenerative medicine and cell therapy.<\/p>\n<\/div>\n<h2>FBS vs hPL for MSC expansion<\/h2>\n<p>Multiple published studies comparing FBS and hPL for MSC expansion consistently find: hPL at 5% supports higher proliferation rates (shorter population doubling time), equivalent or better maintenance of ISCT immunophenotype criteria, and often superior immunomodulatory potency. For clinical-grade MSC manufacturing, hPL is the preferred supplement under EMA ATMP guidelines because it eliminates bovine protein exposure and is available in GMP grade with full donor documentation.<\/p>\n<h2>MSC clinical applications<\/h2>\n<p>MSCs are in clinical trials for: GvHD, Crohn's disease, ARDS, COVID-19 pneumonia, osteoarthritis, myocardial infarction, and ALS. Allogeneic MSC products can often be administered without HLA matching \u2014 enabling off-the-shelf manufacturing approaches.<\/p>\n<h2>Key Facts<\/h2>\n<ul>\n<li>ISCT criteria: plastic-adherent; express CD73, CD90, CD105; lack CD34, CD45, CD14, HLA-DR; differentiate into osteoblasts, chondrocytes, adipocytes<\/li>\n<li>Sources: bone marrow (BM-MSC), adipose tissue (AT-MSC), umbilical cord (UC-MSC, Wharton's Jelly MSC), dental pulp, placenta<\/li>\n<li>Immunomodulatory: suppress T cell proliferation, reduce NK cytotoxicity, polarise macrophages toward M2 \u2014 via PGE2, IDO, TGF-\u03b2, IL-10<\/li>\n<li>Standard expansion: DMEM or \u03b1-MEM + 10% FBS (research) or 5% hPL (clinical grade, xeno-free)<\/li>\n<li>hPL at 5% outperforms FBS at 10% for MSC proliferation in most published studies \u2014 recommended for clinical-grade expansion<\/li>\n<li>Passage limit: clinical protocols typically use MSCs up to passage 5\u20138 to maintain potency<\/li>\n<\/ul>\n<h2>Further Reading<\/h2>\n<ul>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-human-platelet-lysate-hpl\/\">What is hPL?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-atmp\/\">What is ATMP?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/what-is-xeno-free-cell-culture\/\">What is Xeno-Free Cell Culture?<\/a><\/li>\n<li><a href=\"https:\/\/seamlessbio.de\/de\/ressourcen\/blog\/human-platelet-lysate-hpl-fbs-replacement-guide\/\">hPL Complete Guide<\/a><\/li>\n<\/ul>\n<div style=\"background:#f4f6f7;border-radius:12px;padding:32px;text-align:center;margin-top:40px;\">\n<p style=\"font-size:18px;font-weight:700;color:#1a2e35;margin-bottom:12px;\">hPL & FBS for MSC Expansion \u2014 SeamlessBio<\/p>\n<a href=\"https:\/\/seamlessbio.de\/de\/produkte\/menschliches-serum\/\" style=\"background:#18b7b2;color:#fff;padding:12px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">View Product \u2192<\/a>\n&nbsp;&nbsp;\n<a href=\"https:\/\/seamlessbio.de\/de\/kontakt\/\" style=\"border:2px solid #18b7b2;color:#139b97;padding:10px 28px;border-radius:50px;font-size:13px;font-weight:700;text-decoration:none;\">Muster anfordern<\/a>\n<\/div>\n<p style=\"font-size:13px;color:#6b7f82;margin-top:32px;border-top:1px solid #d8e8e7;padding-top:16px;\">\n<em>SeamlessBio GmbH \u00b7 Passau, Germany \u00b7 <a href=\"mailto:info@seamlessbio.de\">info@seamlessbio.de<\/a><\/em>\n<\/p>\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Quick Definition What is an MSC (Mesenchymal Stem Cell)?: Mesenchymal stem cells (MSCs), also called mesenchymal stromal cells, are multipotent adult stem cells found in bone marrow, adipose tissue, umbilical [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_eb_attr":"","footnotes":""},"class_list":["post-3108","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is an MSC (Mesenchymal Stem Cell)? 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