{"id":644,"date":"2026-05-14T16:20:39","date_gmt":"2026-05-14T15:20:39","guid":{"rendered":"http:\/\/seamlessbio.de\/?page_id=644"},"modified":"2026-07-02T22:36:02","modified_gmt":"2026-07-02T21:36:02","slug":"albumin-proteins","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/albumin-proteins\/","title":{"rendered":"Albumin and Proteins Overview"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"644\" class=\"elementor elementor-644\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-402c5b2 e-con e-atomic-element e-flexbox-base e-d2cdb22 \" data-id=\"402c5b2\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"402c5b2\">\n    \t\t<div class=\"elementor-element elementor-element-5ea3986 elementor-widget elementor-widget-html\" data-id=\"5ea3986\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!--\nYOAST SEO \u00b7 Slug: \/products\/albumin-proteins\/\nSEO Title: Albumin & Proteins | BSA, HSA & rHSA | All Grades | SeamlessBio\nMeta Desc: BSA, HSA and recombinant HSA across 4 grades each \u2014 for cell culture, DMPK assay buffers, IVD calibrators and cryoprotection. All grades available. SeamlessBio EU supplier.\n-->\n<script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\": \"ListItem\", \"position\": 1, \"name\": \"Home\", \"item\": \"https:\/\/www.seamlessbio.de\/\"}, {\"@type\": \"ListItem\", \"position\": 2, \"name\": \"Products\", \"item\": \"https:\/\/www.seamlessbio.de\/products\/\"}]},{\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\": \"Question\", \"name\": \"What albumin products does SeamlessBio supply?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"SeamlessBio supplies three albumin families: Bovine Serum Albumin (BSA) in 4 grades, Human Serum Albumin (HSA) in 4 grades and recombinant HSA (rHSA) in 3 variants. BSA grades include Standard, Low Endotoxin, Fatty Acid-Free and pH 5.2. HSA grades include Excipient, Diagnostic, Cell Culture and Research.\"}}, {\"@type\": \"Question\", \"name\": \"What is the difference between HSA and rHSA?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"HSA (Human Serum Albumin) is derived from human plasma. rHSA (recombinant HSA) is produced in yeast or CHO cell expression systems \\u2014 fully xeno-free and human-sequence identical, without the donor variability or viral safety concerns of plasma-derived HSA. rHSA is the preferred choice for GMP cell therapy formulations where xeno-free documentation is required.\"}}, {\"@type\": \"Question\", \"name\": \"Which BSA grade should I use for DMPK assays?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"BSA Fatty Acid-Free is the correct grade for DMPK protein binding assays \\u2014 standard BSA contains endogenous fatty acids that occupy the fatty acid binding sites on albumin, displacing drug molecules and artificially elevating free fraction measurements. Always use fatty acid-free BSA for protein binding and DMPK buffer preparation.\"}}]}]}<\/script>\n<div class=\"sbp-page\"><div class=\"sbp-wrap\">\n<nav class=\"sbp-bc\"><a href=\"https:\/\/www.seamlessbio.de\/\">Home<\/a><span>\/<\/span><a href=\"https:\/\/www.seamlessbio.de\/products\/\">Products<\/a><span>\/<\/span><strong>Albumin & Proteins<\/strong><\/nav>\n<div class=\"sbp-hero\">\n  <span class=\"sbp-eyebrow\">BSA \u00b7 HSA \u00b7 rHSA \u00b7 4 Grades Each \u00b7 EU Supplier<\/span>\n  <h1>Albumin & Proteins<\/h1>\n  <p>Bovine Serum Albumin (BSA), Human Serum Albumin (HSA) and recombinant HSA in multiple grades \u2014 for serum-free cell culture, DMPK assay buffer preparation, IVD calibrator stabilisation, cryoprotection and pharmaceutical formulation. Full documentation per lot.<\/p>\n  <div class=\"sbp-tags\"><span>BSA 4 Grades<\/span><span>HSA 4 Grades<\/span><span>rHSA 3 Variants<\/span><span>US Origin HSA<\/span><span>DMPK Grade Available<\/span><\/div>\n  <div class=\"sbp-btns\"><a href=\"mailto:info@seamlessbio.de?subject=Albumin%20Enquiry\" class=\"sbp-btn\">Request Quote<\/a><a href=\"https:\/\/shop.seamlessbio.de\" class=\"sbp-btn-o\">Visit Shop<\/a><\/div>\n<\/div>\n\n<div class=\"sbp-section\">\n<h2 class=\"sbp-h2\">Bovine Serum Albumin (BSA)<\/h2>\n<p class=\"sbp-intro\">BSA is the most widely used protein supplement in cell culture and biochemical research. SeamlessBio supplies 4 BSA grades matched to specific application requirements.<\/p>\n<div class=\"sbp-grid-4\">\n<a href=\"https:\/\/www.seamlessbio.de\/products\/albumin-proteins\/bsa-standard\/\" class=\"sbp-card-link\"><h3>BSA Standard Grade<\/h3><p>General cell culture, ELISA blocking, assay buffer protein supplement. Cost-effective baseline albumin.<\/p><\/a>\n<a href=\"https:\/\/www.seamlessbio.de\/products\/albumin-proteins\/bsa-low-endotoxin\/\" class=\"sbp-card-link\"><h3>BSA Low Endotoxin<\/h3><p>\u22641 EU\/mg endotoxin. For endotoxin-sensitive cell culture, immunoassay development and cytokine release assays.<\/p><\/a>\n<a href=\"https:\/\/www.seamlessbio.de\/products\/albumin-proteins\/bsa-fatty-acid-free\/\" class=\"sbp-card-link\"><h3>BSA Fatty Acid-Free<\/h3><p>Endogenous fatty acids removed. Essential for DMPK protein binding assays and lipid binding research.<\/p><\/a>\n<a href=\"https:\/\/www.seamlessbio.de\/products\/albumin-proteins\/bsa-ph-5-2\/\" class=\"sbp-card-link\"><h3>BSA pH 5.2<\/h3><p>Specific pH formulation for buffer systems requiring acidic albumin. For specialist formulation applications.<\/p><\/a>\n<\/div>\n<\/div>\n\n<div class=\"sbp-alt\">\n<h2 class=\"sbp-h2\">Human Serum Albumin (HSA)<\/h2>\n<p class=\"sbp-intro\">Plasma-derived HSA in 4 grades \u2014 from pharmacopoeial excipient grade through to research use. US-origin. Full documentation per lot including TSE\/BSE statement.<\/p>\n<div class=\"sbp-grid-4\">\n<a href=\"https:\/\/www.seamlessbio.de\/products\/albumin-proteins\/human-serum-albumin\/\" class=\"sbp-card-link\"><h3>HSA Excipient Grade<\/h3><p>Pharmacopoeial, for pharmaceutical formulations. EP\/USP compliant. Full pharma documentation package.<\/p><\/a>\n<a href=\"https:\/\/www.seamlessbio.de\/products\/albumin-proteins\/human-serum-albumin\/\" class=\"sbp-card-link\"><h3>HSA Diagnostic Grade<\/h3><p>For IVD calibrator and control manufacturing. Lot-specific quantitative testing. IVDR documentation on request.<\/p><\/a>\n<a href=\"https:\/\/www.seamlessbio.de\/products\/albumin-proteins\/human-serum-albumin\/\" class=\"sbp-card-link\"><h3>HSA Cell Culture Grade<\/h3><p>Xeno-free, ISO 13485-aligned. For ATMP and cell therapy formulations, cryoprotection and defined serum-free media.<\/p><\/a>\n<a href=\"https:\/\/www.seamlessbio.de\/products\/albumin-proteins\/human-serum-albumin\/\" class=\"sbp-card-link\"><h3>HSA Research Grade<\/h3><p>Cost-effective HSA for research applications. Full CoA, CoO, TSE\/BSE statement per lot.<\/p><\/a>\n<\/div>\n<p style=\"font-size:13px;color:#999;margin-top:16px\">Available as 5%, 20% and 25% solutions in PET\/PETG vials and single-use bags (250 mL \u2013 5 L). All on request.<\/p>\n<\/div>\n\n<div class=\"sbp-section\">\n<h2 class=\"sbp-h2\">Recombinant HSA (rHSA)<\/h2>\n<p class=\"sbp-intro\">Produced in yeast or CHO expression systems \u2014 human-sequence identical, fully xeno-free, without plasma donor variability or viral safety concerns. The preferred albumin for GMP cell therapy and advanced manufacturing.<\/p>\n<div class=\"sbp-grid-3\">\n<a href=\"https:\/\/www.seamlessbio.de\/products\/albumin-proteins\/rhsa-economy\/\" class=\"sbp-card-link\"><h3>rHSA Economy<\/h3><p>Yeast-expressed recombinant HSA. Cost-effective xeno-free albumin for research and process development applications.<\/p><\/a>\n<a href=\"https:\/\/www.seamlessbio.de\/products\/albumin-proteins\/rhsa-premium\/\" class=\"sbp-card-link\"><h3>rHSA Premium<\/h3><p>High purity yeast-expressed rHSA for xeno-free defined cell culture, MSC expansion media and cell therapy formulation.<\/p><\/a>\n<a href=\"https:\/\/www.seamlessbio.de\/products\/albumin-proteins\/rhsa-cho-expressed\/\" class=\"sbp-card-link\"><h3>rHSA CHO-Expressed<\/h3><p>Human CHO cell-line expressed rHSA. Highest purity for clinical-stage manufacturing. ISO 13485 documentation available.<\/p><\/a>\n<\/div>\n<\/div>\n\n<div class=\"sbp-alt\">\n<h2 class=\"sbp-h2\">HSA vs. rHSA \u2014 Which to Choose?<\/h2>\n<table class=\"sbp-table\">\n<tr><th>Parameter<\/th><th>HSA (Plasma-Derived)<\/th><th>rHSA (Recombinant)<\/th><\/tr>\n<tr><td>Source<\/td><td>Human plasma (US donors)<\/td><td>Yeast or CHO expression system<\/td><\/tr>\n<tr><td>Xeno-free<\/td><td>Human-derived \u2014 xeno-free<\/td><td>Fully xeno-free, no animal components<\/td><\/tr>\n<tr><td>Lot variability<\/td><td>Some donor-to-donor variation<\/td><td>Highly consistent \u2014 defined expression system<\/td><\/tr>\n<tr><td>Viral safety<\/td><td>Viral inactivation step required<\/td><td>No viral safety concerns<\/td><\/tr>\n<tr><td>Best for<\/td><td>IVD calibrators, pharma formulation, cell culture<\/td><td>GMP cell therapy, ATMP, defined media<\/td><\/tr>\n<tr><td>Cost<\/td><td>Lower<\/td><td>Higher \u2014 but preferred for GMP<\/td><\/tr>\n<\/table>\n<a href=\"https:\/\/www.seamlessbio.de\/compare\/hsa-rhsa-grades-comparison\/\" class=\"sbp-btn\" style=\"margin-top:20px;display:inline-block\">Full HSA vs rHSA Guide \u2192<\/a>\n<\/div>\n\n<div class=\"sbp-section\">\n<h2 class=\"sbp-h2\">Frequently Asked Questions<\/h2>\n<div class=\"sbp-faq\"><h3>Which BSA grade for DMPK assays?<\/h3><p>BSA Fatty Acid-Free only \u2014 standard BSA contains endogenous fatty acids that occupy the fatty acid binding sites, displacing drug molecules and artificially elevating free fraction measurements. Always use fatty acid-free BSA for DMPK protein binding assays.<\/p><\/div>\n<div class=\"sbp-faq\"><h3>What HSA concentration is isotonic?<\/h3><p>HSA 5% (50 g\/L) is isotonic \u2014 equivalent to physiological plasma albumin concentration. Standard for cell washing, separation buffers and isotonic infusion formulations. HSA 20% and 25% are concentrated and diluted to working concentration at point of use.<\/p><\/div>\n<div class=\"sbp-faq\"><h3>Is rHSA truly xeno-free?<\/h3><p>Yes \u2014 rHSA expressed in yeast (Pichia pastoris) contains no animal-derived components in the final product. CHO-expressed rHSA uses an animal cell line but the product itself is recombinant human albumin with no animal-derived contaminants in the final purified material. Full xeno-free documentation available.<\/p><\/div>\n<\/div>\n\n<div class=\"sbp-cta\"><h2>Request Albumin & Proteins<\/h2><p>BSA, HSA and rHSA \u2014 all grades available. Quote within 48 hours. Free test samples on request.<\/p><div class=\"sbp-cta-btns\"><a href=\"https:\/\/www.seamlessbio.de\/about-us\/contact-imprint\/\" class=\"sbp-btn\">Contact Us<\/a><a href=\"https:\/\/shop.seamlessbio.de\" class=\"sbp-btn-o\">Visit Shop<\/a><\/div><\/div>\n<\/div><\/div>\n<style>\n.sbp-page,.sbp-page *{box-sizing:border-box}\n.sbp-page{font-family:Arial,sans-serif;color:#202020;background:#fff;padding:60px 0 90px}\n.sbp-wrap{max-width:1400px;margin:0 auto;padding:0 40px}\n.sbp-bc{display:flex;flex-wrap:wrap;gap:6px;align-items:center;font-size:13px;color:#999;margin-bottom:32px}\n.sbp-bc a{color:#18b7b2!important;text-decoration:none!important;font-weight:600}.sbp-bc span{color:#ddd}\n.sbp-hero{background:#f7fbfb;border:1px solid rgba(24,183,178,.15);border-radius:24px;padding:52px;margin-bottom:56px}\n.sbp-eyebrow{display:inline-block;font-size:12px;font-weight:800;letter-spacing:.1em;text-transform:uppercase;color:#18b7b2;margin-bottom:14px}\n.sbp-hero 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