{"id":9072,"date":"2026-09-24T22:38:14","date_gmt":"2026-09-24T21:38:14","guid":{"rendered":"https:\/\/seamlessbio.de\/?page_id=9072"},"modified":"2026-09-24T22:40:35","modified_gmt":"2026-09-24T21:40:35","slug":"rf-positive-human-plasma","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/rf-positive-human-plasma\/","title":{"rendered":"RF-Positive Human Plasma"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"9072\" class=\"elementor elementor-9072\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-724b3b2 e-con e-atomic-element e-flexbox-base e-default-div e-120afcd \" data-id=\"724b3b2\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"724b3b2\" data-e-type=\"e-flexbox\" data-id=\"724b3b2\">\n    \t\t<div class=\"elementor-element elementor-element-6bb464b elementor-widget elementor-widget-html\" data-id=\"6bb464b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<title>RF-Positive Human Plasma<\/title>\n<link rel=\"stylesheet\" href=\"https:\/\/fonts.googleapis.com\/css2?family=Inter:wght@400;500;600;700;800&display=swap\">\n<style>\n:root {\n  --t: #18b7b2;\n  --th: #139b97;\n  --d: #202020;\n  --g: #5b6b71;\n  --bg: #f1faf9;\n  --ln: #e2eceb;\n  --white: #ffffff;\n  color-scheme: light;\n}\n\n*, *::before, *::after { box-sizing: border-box; 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}\n.sb-tw tr:hover td { background: var(--bg); }\n.sb-tw td.titer-val {\n  font-weight: 800;\n  color: var(--th);\n  font-variant-numeric: tabular-nums;\n  white-space: nowrap;\n}\n\n\/* \u2500\u2500 SPECS GRID \u2500\u2500 *\/\n.sb-specs-grid {\n  display: grid;\n  grid-template-columns: 1fr 1fr;\n  gap: 20px;\n}\n@media (max-width: 640px) { .sb-specs-grid { grid-template-columns: 1fr; } }\n\n.sb-spec-box {\n  border: 1px solid var(--ln);\n  border-radius: 12px;\n  overflow: hidden;\n}\n.sb-spec-box-head {\n  background: var(--bg);\n  padding: 13px 18px;\n  font-weight: 700;\n  font-size: 14px;\n  border-bottom: 1px solid var(--ln);\n}\n.sb-spec-row {\n  display: flex;\n  justify-content: space-between;\n  align-items: flex-start;\n  padding: 11px 18px;\n  border-bottom: 1px solid var(--ln);\n  gap: 16px;\n  font-size: 14px;\n}\n.sb-spec-row:last-child { border-bottom: none; }\n.sb-spec-key { color: var(--g); flex-shrink: 0; }\n.sb-spec-val { font-weight: 600; text-align: right; }\n.sb-spec-val.accent { color: var(--th); }\n\n\/* \u2500\u2500 APPLICATIONS \u2500\u2500 *\/\n.sb-apps-list {\n  display: grid;\n  grid-template-columns: repeat(auto-fill, minmax(240px, 1fr));\n  gap: 10px;\n  list-style: none;\n  padding: 0;\n  margin: 0;\n}\n.sb-apps-list li {\n  background: var(--bg);\n  border: 1px solid var(--ln);\n  border-radius: 10px;\n  padding: 14px 16px 14px 38px;\n  font-size: 14px;\n  line-height: 1.5;\n  position: relative;\n}\n.sb-apps-list li::before {\n  content: '';\n  position: absolute;\n  left: 16px;\n  top: 20px;\n  width: 7px;\n  height: 7px;\n  border-radius: 50%;\n  background: var(--t);\n}\n\n\/* \u2500\u2500 NOTE BOX \u2500\u2500 *\/\n.sb-note {\n  background: var(--bg);\n  border-left: 4px solid var(--t);\n  border-radius: 0 12px 12px 0;\n  padding: 18px 22px;\n  margin-top: 28px;\n  font-size: 15px;\n  color: var(--g);\n}\n.sb-note strong { color: var(--d); }\n\n\n\/* \u2500\u2500 FAQ \u2500\u2500 *\/\n.sb-faq { display: flex; flex-direction: column; gap: 8px; }\n.sb-faq-item {\n  border: 1px solid var(--ln);\n  border-radius: 12px;\n  overflow: hidden;\n}\n.sb-faq-item summary {\n  padding: 16px 20px;\n  font-weight: 700;\n  font-size: 15px;\n  cursor: pointer;\n  list-style: none;\n  display: flex;\n  justify-content: space-between;\n  align-items: center;\n  gap: 12px;\n  background: #fff;\n  transition: background .15s;\n}\n.sb-faq-item summary::-webkit-details-marker { display: none; }\n.sb-faq-item summary::after {\n  content: '+';\n  font-size: 20px;\n  font-weight: 400;\n  color: var(--t);\n  flex-shrink: 0;\n  transition: transform .2s;\n}\n.sb-faq-item[open] summary::after { content: '\u2212'; }\n.sb-faq-item summary:hover { background: var(--bg); }\n.sb-faq-item[open] summary { background: var(--bg); border-bottom: 1px solid var(--ln); }\n.sb-faq-item p {\n  padding: 16px 20px;\n  margin: 0;\n  font-size: 14px;\n  color: var(--g);\n  line-height: 1.65;\n}\n\n<\/style>\n\n<div class=\"sb-rf-page\">\n<!-- HERO -->\n  <div class=\"sb-rf-hero\">\n    <div class=\"sb-rf-hero-text\">\n      <div class=\"sb-rf-hero-eyebrow\">SeamlessBio \u2014 Disease State Plasma<\/div>\n      <h1>Human Plasma,<br>Rheumatoid Factor (RF) Positive<\/h1>\n      <p>\n        Disease-state human plasma from donors with confirmed elevated rheumatoid factor levels. Available across six titer thresholds \u2014 from &gt;200 to &gt;4,000 IU\/mL \u2014 for immunoassay development, QC panels, and IVD reagent manufacturing.\n      <\/p>\n      <div class=\"sb-rf-btns\">\n        <a href=\"https:\/\/seamlessbio.de\/about-us\/contact-imprint\/\" class=\"sb-rf-btn\">Contact Us<\/a>\n      <\/div>\n    <\/div>\n    <div class=\"sb-rf-hero-badge\">\n      <div class=\"badge-label\">Available Titers<\/div>\n      <div class=\"badge-val\">6 Levels<\/div>\n      <div class=\"badge-sub\">&gt;200 \u2013 &gt;4,000 IU\/mL<\/div>\n      <hr class=\"badge-divider\">\n      <div class=\"badge-label\">Intended Use<\/div>\n      <div class=\"badge-val\" style=\"font-size:15px\">RUO \/ IVD Mfg.<\/div>\n    <\/div>\n  <\/div>\n\n  <!-- FEATURE CARDS -->\n  <div class=\"sb-rf-grid\">\n    <div class=\"sb-rf-card\">\n      <span>01<\/span>\n      <h3>Six Titer Levels<\/h3>\n      <p>&gt;200, &gt;500, &gt;700, &gt;1,000, &gt;2,500, &gt;4,000 IU\/mL \u2014 matched to your assay range.<\/p>\n    <\/div>\n    <div class=\"sb-rf-card\">\n      <span>02<\/span>\n      <h3>Confirmed RF Positivity<\/h3>\n      <p>Each lot is screened and released against the stated titer threshold with full donor documentation.<\/p>\n    <\/div>\n    <div class=\"sb-rf-card\">\n      <span>03<\/span>\n      <h3>IVDR-Ready Matrix<\/h3>\n      <p>Human plasma matrix for IVDR Class B\/C performance validation and positive control formulation.<\/p>\n    <\/div>\n    <div class=\"sb-rf-card\">\n      <span>04<\/span>\n      <h3>EU Stock &amp; Lot Reservation<\/h3>\n      <p>Supplied from Europe via SeamlessBio. Lot reservation available for long-term manufacturing projects.<\/p>\n    <\/div>\n  <\/div>\n\n  <!-- TITER TABLE -->\n  <div class=\"sb-sec\">\n    <h2>Available Titer Levels<\/h2>\n    <p class=\"lede\">All six variants are produced to the same quality standard \u2014 choose the threshold that fits your assay window.<\/p>\n    <div class=\"sb-tw\">\n      <table>\n        <thead>\n          <tr>\n            <th>RF Titer<\/th>\n            <th>Typical Application<\/th>\n            <th>Format<\/th>\n            \n          <\/tr>\n        <\/thead>\n        <tbody>\n          <tr>\n            <td class=\"titer-val\">&gt; 200 IU\/mL<\/td>\n            <td>Low-range screening, threshold controls<\/td>\n            <td>1 \u2013 50 mL<\/td>\n          <\/tr>\n          <tr>\n            <td class=\"titer-val\">&gt; 500 IU\/mL<\/td>\n            <td>Standard positive control, ELISA validation<\/td>\n            <td>1 \u2013 50 mL<\/td>\n          <\/tr>\n          <tr>\n            <td class=\"titer-val\">&gt; 700 IU\/mL<\/td>\n            <td>Mid-range; matrix and interference studies<\/td>\n            <td>1 \u2013 50 mL<\/td>\n          <\/tr>\n          <tr>\n            <td class=\"titer-val\">&gt; 1,000 IU\/mL<\/td>\n            <td>High-titer positive control, QC panel anchoring<\/td>\n            <td>1 \u2013 50 mL<\/td>\n          <\/tr>\n          <tr>\n            <td class=\"titer-val\">&gt; 2,500 IU\/mL<\/td>\n            <td>Elevated-range stress testing and linearity<\/td>\n            <td>1 \u2013 50 mL<\/td>\n          <\/tr>\n          <tr>\n            <td class=\"titer-val\">&gt; 4,000 IU\/mL<\/td>\n            <td>Hook-effect studies, maximum-range calibration<\/td>\n            <td>1 \u2013 50 mL<\/td>\n          <\/tr>\n        <\/tbody>\n      <\/table>\n    <\/div>\n    <div class=\"sb-note\">\n      <strong>Mixed-titer orders welcome.<\/strong> If your QC panel requires multiple titer levels, contact us for a combined order \u2014 we can supply all six variants in a single shipment with matched lot documentation.\n    <\/div>\n  <\/div>\n\n  <!-- SPECS -->\n  <div class=\"sb-sec\">\n    <h2>Product Specifications<\/h2>\n    <p class=\"lede\">Full lot documentation including CoA and donor screening data is supplied with every order.<\/p>\n    <div class=\"sb-specs-grid\">\n      <div class=\"sb-spec-box\">\n        <div class=\"sb-spec-box-head\">Technical Details<\/div>\n        <div class=\"sb-spec-row\"><span class=\"sb-spec-key\">Source<\/span><span class=\"sb-spec-val\">Human plasma (disease-state donor)<\/span><\/div>\n        <div class=\"sb-spec-row\"><span class=\"sb-spec-key\">Matrix<\/span><span class=\"sb-spec-val\">Plasma (anticoagulated)<\/span><\/div>\n        <div class=\"sb-spec-row\"><span class=\"sb-spec-key\">Analyte<\/span><span class=\"sb-spec-val accent\">Rheumatoid Factor (RF)<\/span><\/div>\n        <div class=\"sb-spec-row\"><span class=\"sb-spec-key\">Titer Range<\/span><span class=\"sb-spec-val accent\">&gt;200 \u2013 &gt;4,000 IU\/mL<\/span><\/div>\n        <div class=\"sb-spec-row\"><span class=\"sb-spec-key\">Storage<\/span><span class=\"sb-spec-val\">\u221220 \u00b0C (avoid repeated freeze-thaw)<\/span><\/div>\n        <div class=\"sb-spec-row\"><span class=\"sb-spec-key\">Volumes<\/span><span class=\"sb-spec-val\">1 mL, 2 mL, 5 mL, 10 mL, 20 mL, 50 mL<\/span><\/div>\n        <div class=\"sb-spec-row\"><span class=\"sb-spec-key\">Documentation<\/span><span class=\"sb-spec-val\">CoA, donor screening data<\/span><\/div>\n      <\/div>\n      <div class=\"sb-spec-box\">\n        <div class=\"sb-spec-box-head\">Supply &amp; Regulatory<\/div>\n        \n        \n        <div class=\"sb-spec-row\"><span class=\"sb-spec-key\">Intended Use<\/span><span class=\"sb-spec-val\">RUO \/ IVD manufacturing<\/span><\/div>\n        <div class=\"sb-spec-row\"><span class=\"sb-spec-key\">IVDR Relevance<\/span><span class=\"sb-spec-val\">Positive control for Class B\/C assays<\/span><\/div>\n        <div class=\"sb-spec-row\"><span class=\"sb-spec-key\">Lead Time<\/span><span class=\"sb-spec-val\">Typically 2\u20134 weeks (lot-dependent)<\/span><\/div>\n        <div class=\"sb-spec-row\"><span class=\"sb-spec-key\">Lot Reservation<\/span><span class=\"sb-spec-val\">Available on request<\/span><\/div>\n      <\/div>\n    <\/div>\n  <\/div>\n\n  <!-- APPLICATIONS -->\n  <div class=\"sb-sec\">\n    <h2>Applications<\/h2>\n    <p class=\"lede\">RF-positive plasma is required wherever a human-matrix positive control with defined autoantibody titer is needed.<\/p>\n    <ul class=\"sb-apps-list\">\n      <li>Immunoassay development for RF detection (ELISA, CLIA, nephelometry, latex agglutination)<\/li>\n      <li>Positive control material for IVD kit QC panels<\/li>\n      <li>Cross-reactivity and specificity studies in autoimmune assay development<\/li>\n      <li>Linearity and hook-effect evaluation at high titer levels<\/li>\n      <li>IVDR analytical performance assessment \u2014 sensitivity and specificity<\/li>\n      <li>Calibrator matrix formulation for quantitative RF assays<\/li>\n      <li>Proficiency testing and external QC programs for clinical labs<\/li>\n      <li>Research into complement activation and RF-mediated immune complex formation<\/li>\n    <\/ul>\n  <\/div>\n\n\n  <!-- FAQ -->\n  <div class=\"sb-sec\">\n    <h2>Frequently Asked Questions<\/h2>\n    <p class=\"lede\">Common questions from assay developers and IVD manufacturers.<\/p>\n    <div class=\"sb-faq\">\n\n      <details class=\"sb-faq-item\">\n        <summary>What is RF-positive human plasma used for in diagnostics?<\/summary>\n        <p>RF-positive plasma serves as a disease-state positive control in immunoassays that detect rheumatoid factor (RF) \u2014 an autoantibody elevated in rheumatoid arthritis and other autoimmune conditions. It is used for assay development, calibration, QC panel formulation, and IVDR performance validation of RF detection kits (ELISA, CLIA, nephelometry, latex agglutination).<\/p>\n      <\/details>\n\n      <details class=\"sb-faq-item\">\n        <summary>What is the difference between the six titer levels?<\/summary>\n        <p>Each titer level defines the minimum confirmed RF concentration in the plasma: &gt;200, &gt;500, &gt;700, &gt;1,000, &gt;2,500, and &gt;4,000 IU\/mL. Lower titers are used for threshold controls and screening assays; higher titers are needed for linearity studies, hook-effect testing, and high-range calibration. Choose the level that matches your assay's measurement range.<\/p>\n      <\/details>\n\n      <details class=\"sb-faq-item\">\n        <summary>Is this plasma suitable for IVDR compliance?<\/summary>\n        <p>Yes. The human plasma matrix and confirmed RF titer make this material suitable for IVDR analytical performance studies including sensitivity, specificity, and trueness assessment for Class B and C in-vitro diagnostic devices. Full lot documentation (CoA, donor screening data) is supplied with every order to support your technical file.<\/p>\n      <\/details>\n\n      <details class=\"sb-faq-item\">\n        <summary>Can I order multiple titer levels in one shipment?<\/summary>\n        <p>Yes \u2014 mixed-titer orders are welcome. If your QC panel requires several levels, we can consolidate all variants into a single shipment with matched lot documentation. Contact us with your requirements and we will provide a combined quote.<\/p>\n      <\/details>\n\n      <details class=\"sb-faq-item\">\n        <summary>What volumes are available?<\/summary>\n        <p>Standard volumes are 1, 2, 5, 10, 20, and 50 mL per titer level. For larger bulk quantities (&gt;50 mL), please contact us to discuss lot availability and lead time.<\/p>\n      <\/details>\n\n      <details class=\"sb-faq-item\">\n        <summary>How should RF-positive plasma be stored?<\/summary>\n        <p>Store at \u221220 \u00b0C upon receipt. Avoid repeated freeze-thaw cycles, as these can degrade antibody activity and affect titer accuracy. For frequent use, aliquot into single-use volumes before freezing.<\/p>\n      <\/details>\n\n      <details class=\"sb-faq-item\">\n        <summary>What is the typical lead time?<\/summary>\n        <p>Lead time is typically 2\u20134 weeks depending on lot availability. For long-term manufacturing projects, lot reservation is available \u2014 contact us early to secure a dedicated lot for your production schedule.<\/p>\n      <\/details>\n\n      <details class=\"sb-faq-item\">\n        <summary>Is this product available for research use only (RUO)?<\/summary>\n        <p>Yes. This material is available for both RUO (Research Use Only) and IVD manufacturing use. It is not intended for direct clinical diagnostic use on patient samples.<\/p>\n      <\/details>\n\n    <\/div>\n  <\/div>\n\n<\/div><!-- \/sb-rf-page -->\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>RF-Positive Human Plasma SeamlessBio \u2014 Disease State Plasma Human Plasma,Rheumatoid Factor (RF) Positive Disease-state human plasma from donors with confirmed elevated rheumatoid factor levels. Available across six titer thresholds \u2014 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_eb_attr":"","_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","footnotes":""},"class_list":["post-9072","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>RF-Positive Human Plasma | 6 Titer Levels &gt;200\u2013&gt;4,000 IU\/mL<\/title>\n<meta name=\"description\" content=\"RF-positive human plasma for immunoassay development, IVD manufacturing &amp; IVDR validation. Six titer levels (&gt;200 to &gt;4,000 IU\/mL), available in 1\u201350 mL. 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