{"id":9226,"date":"2026-10-15T13:06:30","date_gmt":"2026-10-15T12:06:30","guid":{"rendered":"https:\/\/wheat-quail-856400.hostingersite.com\/?page_id=9226"},"modified":"2026-11-04T18:54:38","modified_gmt":"2026-11-04T17:54:38","slug":"humanserum-plasma-ivd-cro","status":"publish","type":"page","link":"https:\/\/seamlessbio.de\/de\/human-serum-plasma-ivd-cro\/","title":{"rendered":"Anwendung Humanserum vs. Plasma"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"9226\" class=\"elementor elementor-9226\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-169e9d1 e-con e-atomic-element e-flexbox-base e-default-div e-c046b47 \" data-id=\"169e9d1\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"169e9d1\" data-e-type=\"e-flexbox\" data-id=\"169e9d1\">\n    \t\t<div class=\"elementor-element elementor-element-37d4d34 elementor-widget elementor-widget-html\" data-id=\"37d4d34\" 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.ctab1:hover{background:#139b97;transform:translateY(-2px);}.sb-app .ctab2{background:transparent;border:2px solid #18b7b2;color:#18b7b2!important;}.sb-app .ctab2:hover{background:#18b7b2;color:#fff!important;transform:translateY(-2px);}@media(max-width:1100px){.sb-app .hero{padding:48px 36px;}.sb-app .rel-grid{grid-template-columns:1fr;}}@media(max-width:700px){.sb-app{padding:50px 16px 70px;}.sb-app .hero{padding:40px 24px;border-radius:24px;}.sb-app .hero h1{font-size:25px;}.sb-app .hbtns,.sb-app .ctabtns{flex-direction:column;}.sb-app .btn1,.sb-app .btn2,.sb-app .ctab1,.sb-app .ctab2{width:100%;}.sb-app .sec,.sb-app .faq{padding:20px;}.sb-app .cta{padding:36px 20px;}}<\/style>\n\n<div class=\"wrap\">\n  <div class=\"bc\">\n    <a href=\"https:\/\/seamlessbio.de\/\">Home<\/a><span>\/<\/span>\n    <a href=\"https:\/\/seamlessbio.de\/applications\/\">Applications<\/a><span>\/<\/span>\n    <strong>Human Serum &amp; Plasma<\/strong>\n  <\/div>\n\n  <div class=\"hero\">\n    <span class=\"ey\">SeamlessBio \u2014 Human Biologicals \u00b7 EU Stock \u00b7 IVD &amp; CRO Supply<\/span>\n    <h1>Human Serum &amp; Plasma for IVD, CRO &amp; Bioanalytical Applications \u2014 EU Delivery<\/h1>\n    <p class=\"sub\">The right human matrix makes or breaks your assay. SeamlessBio supplies Human Serum Type AB and Human Plasma (citrate, apheresis) from EU-sourced, fully documented donors \u2014 for matrix matching, assay validation, calibrator preparation, and method development. No minimum order, same-week delivery across the EU.<\/p>\n    <div class=\"hbtns\">\n      <a href=\"https:\/\/seamlessbio.de\/products\/human-sera-plasma-and-more\/human-serum-type-ab-male\" class=\"btn1\">Order Human Serum<\/a>\n      <a href=\"mailto:info@seamlessbio.de\" class=\"btn2\">Request Custom Lot<\/a>\n    <\/div>\n  <\/div>\n\n  <div class=\"sec\">\n    \n<!-- BUY BOX (SEO: links to buy pages) -->\n<div class=\"sb-buy-box\" style=\"border:1px solid #cfe9e6;background:#f4fbfa;border-radius:12px;padding:22px 26px;margin:28px auto;max-width:1200px;box-sizing:border-box\">\n<h2 style=\"font-size:22px;line-height:1.3;margin:0 0 6px\">Order human serum and plasma from our EU stock<\/h2>\n<p style=\"margin:0 0 14px\">Request a quote or a free test sample \u2013 EU stock, no minimum order, lot reservation up to 36 months.<\/p>\n<ul style=\"margin:0;padding-left:20px;columns:2 300px;column-gap:32px\">\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/product\/human-serum-type-ab-male-eu-us-origin-sterile\/\">Human Serum Type AB Male \u2013 EU\/US origin<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/product\/human-serum-type-ab-mixed-donors-eu-us-origin-sterile-filtered\/\">Human AB Serum, Mixed Donors \u2013 heat inactivated<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/product\/human-serum-off-the-clot-eu-us-origin-sterile-filtered\/\">Human Serum Off-the-Clot \u2013 EU\/US origin<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/product\/human-apheresis-plasma-bulk-eu-origin\/\">Human Plasma \u2013 apheresis, EDTA\/citrate\/heparin<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/product\/human-plasma-pooled-eu-us-origin\/\">Pooled Human Plasma \u2013 EU & US donors<\/a><\/li>\n<li style=\"margin:0 0 6px\"><a href=\"https:\/\/seamlessbio.de\/product\/human-plasma-single-donor-eu-origin\/\">Single Donor Human Plasma \u2013 EU origin<\/a><\/li>\n<\/ul>\n<\/div>\n<h2>Serum or Plasma \u2014 Which Do You Need?<\/h2>\n    <p>The choice between serum and plasma depends entirely on your assay type and regulatory requirements. Using the wrong matrix introduces systematic error that cannot be corrected downstream.<\/p>\n    <div class=\"tw\">\n      <table>\n        <thead><tr><th>Application<\/th><th>Use Serum<\/th><th>Use Plasma<\/th><\/tr><\/thead>\n        <tbody>\n          <tr><td>Immunoassay \/ ELISA (antibodies, hormones, tumour markers)<\/td><td class=\"ok\">\u2713 Preferred<\/td><td>Possible, check kit<\/td><\/tr>\n          <tr><td>Serology (HIV, Hepatitis, syphilis)<\/td><td class=\"ok\">\u2713 Preferred<\/td><td>\u2014<\/td><\/tr>\n          <tr><td>IVD calibrator &amp; control matrix matching<\/td><td class=\"ok\">\u2713 Standard<\/td><td>For coagulation kits<\/td><\/tr>\n          <tr><td>Drug level assays (PK\/TDM)<\/td><td class=\"ok\">\u2713 Preferred<\/td><td>Possible (heparin-plasma)<\/td><\/tr>\n          <tr><td>Matrix effect validation (FDA\/EMA bioanalytical guidance)<\/td><td class=\"ok\">\u2713 Six individual lots<\/td><td class=\"ok\">\u2713 Six individual lots<\/td><\/tr>\n          <tr><td>Coagulation assays (PT, aPTT, fibrinogen)<\/td><td>\u2014<\/td><td class=\"ok\">\u2713 Citrate plasma required<\/td><\/tr>\n          <tr><td>Biomarker discovery \/ proteomics<\/td><td>\u2014<\/td><td class=\"ok\">\u2713 EDTA or citrate plasma<\/td><\/tr>\n          <tr><td>Cell culture supplement \/ conditioned media<\/td><td class=\"ok\">\u2713 Human AB Serum<\/td><td>\u2014<\/td><\/tr>\n        <\/tbody>\n      <\/table>\n    <\/div>\n  <\/div>\n\n  <div class=\"sec\">\n    <h2>Human Serum Type AB \u2014 Specifications<\/h2>\n    <p>Pooled from male AB-type donors \u2014 the universal serum matrix for immunoassay development and cell culture applications requiring a human matrix without ABO antibody interference.<\/p>\n    <div class=\"tw\">\n      <table>\n        <thead><tr><th>Specification<\/th><th>Detail<\/th><\/tr><\/thead>\n        <tbody>\n          <tr><td><strong>Blood group<\/strong><\/td><td>Type AB, male donors<\/td><\/tr>\n          <tr><td><strong>Source<\/strong><\/td><td>EU-sourced, fully traceable donor documentation<\/td><\/tr>\n          <tr><td><strong>Sterility<\/strong><\/td><td>Sterile filtered (0.2 \u00b5m); tested negative for HBsAg, HCV, HIV-1\/2, syphilis<\/td><\/tr>\n          <tr><td><strong>Haemolysis<\/strong><\/td><td>&lt; 20 mg\/dL haemoglobin (non-haemolytic grade)<\/td><\/tr>\n          <tr><td><strong>Format<\/strong><\/td><td>From 1 mL to bulk; pooled or individual donor lots available on request<\/td><\/tr>\n          <tr><td><strong>Storage<\/strong><\/td><td>\u221220 \u00b0C; shipped on dry ice<\/td><\/tr>\n          <tr><td><strong>Documentation<\/strong><\/td><td>CoA, donor screening report, lot-specific data on request<\/td><\/tr>\n        <\/tbody>\n      <\/table>\n    <\/div>\n  <\/div>\n\n  <div class=\"sec\">\n    <h2>Human Plasma \u2014 Citrate &amp; Apheresis<\/h2>\n    <p>Citrate-anticoagulated human plasma from apheresis donors \u2014 for coagulation assay development, biomarker studies, and applications requiring intact clotting factors.<\/p>\n    <div class=\"tw\">\n      <table>\n        <thead><tr><th>Specification<\/th><th>Detail<\/th><\/tr><\/thead>\n        <tbody>\n          <tr><td><strong>Anticoagulant<\/strong><\/td><td>Sodium citrate (3.2 %); EDTA available on request<\/td><\/tr>\n          <tr><td><strong>Collection method<\/strong><\/td><td>Apheresis \u2014 higher volume per donor, reduced lot variability<\/td><\/tr>\n          <tr><td><strong>Source<\/strong><\/td><td>EU-sourced (Poland); fully traceable<\/td><\/tr>\n          <tr><td><strong>Sterility<\/strong><\/td><td>Sterile filtered; tested for HBsAg, HCV, HIV-1\/2<\/td><\/tr>\n          <tr><td><strong>Clotting factors<\/strong><\/td><td>Intact \u2014 suitable for PT, aPTT, fibrinogen, FVIII assays<\/td><\/tr>\n          <tr><td><strong>Format<\/strong><\/td><td>Individual donor aliquots or pooled; 1 mL to bulk<\/td><\/tr>\n          <tr><td><strong>Storage<\/strong><\/td><td>\u221280 \u00b0C; shipped on dry ice<\/td><\/tr>\n        <\/tbody>\n      <\/table>\n    <\/div>\n  <\/div>\n\n  <div class=\"sec\">\n    <h2>Bioanalytical Method Validation \u2014 FDA &amp; EMA Matrix Requirements<\/h2>\n    <p>Both FDA (2018) and EMA (2011) bioanalytical guidance require matrix matching with the intended study matrix. For human PK studies, this means validated calibrators and QCs prepared in human serum or plasma \u2014 with at least six individual donor lots demonstrated for selectivity.<\/p>\n<p>Need EDTA plasma in K2EDTA, K3EDTA or sodium EDTA, individual donor sets or hemolyzed and lipemic plasma for your PK method? See our page on <a href=\"\/human-edta-plasma-pk-bioanalysis\/\">human EDTA plasma for PK studies and bioanalysis<\/a>.<\/p>\n    <div class=\"tw\">\n      <table>\n        <thead><tr><th>Validation Requirement<\/th><th>What You Need<\/th><th>SeamlessBio Format<\/th><\/tr><\/thead>\n        <tbody>\n          <tr><td>Selectivity (\u2265 6 individual donor lots)<\/td><td>6 \u00d7 individual serum or plasma lots, same matrix type<\/td><td>Individual donor aliquots, lot-specific CoA per vial<\/td><\/tr>\n          <tr><td>Matrix effect (IS-normalised)<\/td><td>\u2265 6 individual lots, spiked at LQC and HQC<\/td><td>Individual lots, matched anticoagulant<\/td><\/tr>\n          <tr><td>Calibrator \/ QC preparation<\/td><td>Pooled matrix, protein-normal, documented<\/td><td>Pooled Human Serum AB or pooled citrate plasma<\/td><\/tr>\n          <tr><td>Haemolysed \/ lipaemic matrix<\/td><td>Surrogate samples for interference testing<\/td><td>Available on request<\/td><\/tr>\n        <\/tbody>\n      <\/table>\n    <\/div>\n  <\/div>\n\n  <div class=\"faq\">\n    <h2>Frequently Asked Questions<\/h2>\n    <div class=\"faq-item\">\n      <div class=\"faq-q\">Why Type AB male serum specifically?<\/div>\n      <div class=\"faq-a\">Type AB serum contains no ABO antibodies, eliminating one source of lot-to-lot interference in immunoassays. Male donors are preferred because female donors may carry HLA antibodies from prior pregnancies, which can interfere with certain assay formats. For most IVD calibration and cell culture applications, AB male pooled serum is the industry standard.<\/div>\n    <\/div>\n    <div class=\"faq-item\">\n      <div class=\"faq-q\">Can I request individual donor lots for selectivity testing?<\/div>\n      <div class=\"faq-a\">Yes. SeamlessBio supplies individual donor aliquots with per-lot CoA and donor screening documentation \u2014 specifically to support the six-lot selectivity and matrix effect panels required under FDA and EMA bioanalytical guidance. Contact us with your volume and lot count requirements.<\/div>\n    <\/div>\n    <div class=\"faq-item\">\n      <div class=\"faq-q\">What is the minimum order quantity?<\/div>\n      <div class=\"faq-a\">There is no minimum order. Method development quantities starting from 1 mL per lot are available. For larger validation panels or production batches, we supply up to bulk volumes \u2014 contact us for a quote.<\/div>\n    <\/div>\n    <div class=\"faq-item\">\n      <div class=\"faq-q\">How quickly can you deliver to Germany, Austria, and Switzerland?<\/div>\n      <div class=\"faq-a\">Standard delivery: 24\u201348 hours to Germany and Austria; 2\u20133 days to Switzerland (export documentation included). Shipment on dry ice; cold-chain continuity documentation available on request.<\/div>\n    <\/div>\n    <div class=\"faq-item\">\n      <div class=\"faq-q\">Can Human Serum AB be used for cell culture \u2014 T cell expansion, CAR-T, MSC?<\/div>\n      <div class=\"faq-a\">Yes. Human AB Serum is used as a supplement in serum-containing media for primary cell culture, T cell expansion, and MSC culture where a human matrix is required to avoid xenogeneic components. It is not a GMP-grade ATMP starting material by default \u2014 contact us if GMP documentation is required for your application.<\/div>\n    <\/div>\n  <\/div>\n\n  <div class=\"related\">\n    <h3>Related Applications &amp; Products<\/h3>\n    <div class=\"rel-grid\">\n      <a href=\"https:\/\/seamlessbio.de\/applications\/cro-contract-research\">\u2192 CRO &amp; Contract Research Supply Guide<\/a>\n      <a href=\"https:\/\/seamlessbio.de\/applications\/dmpk-abc-transporter-assays\">\u2192 DMPK &amp; ABC Transporter Assays<\/a>\n      <a href=\"https:\/\/seamlessbio.de\/products\/human-sera-plasma-and-more\/human-serum-type-ab-male\">\u2192 Human Serum Type AB Male \u2014 Product Page<\/a>\n      <a href=\"https:\/\/seamlessbio.de\/products\/fetal-bovine-serum\">\u2192 FBS Portfolio<\/a>\n      <a href=\"https:\/\/seamlessbio.de\/products\/bsa\">\u2192 BSA \u2014 IVD &amp; Cell Culture Grade<\/a>\n      <a href=\"https:\/\/seamlessbio.de\/applications\/atmp-cell-gene-therapy\">\u2192 ATMP &amp; Cell Therapy Applications<\/a>\n    <\/div>\n  <\/div>\n\n  <div class=\"hub-back\"><a href=\"https:\/\/seamlessbio.de\/applications\/\">\u2190 All Application Guides Overview<\/a><\/div>\n\n  <div class=\"cta\">\n    <h2>Order Human Serum or Plasma \u2014 or Request a Custom Lot<\/h2>\n    <p>Tell us your matrix type, volume, donor lot count, and application. We respond within 24 hours with a quote and available lot documentation.<br>Email: info@seamlessbio.de | +49 851 37932226<\/p>\n    <div class=\"ctabtns\">\n      <a href=\"https:\/\/seamlessbio.de\/products\/human-sera-plasma-and-more\/human-serum-type-ab-male\" class=\"ctab1\">Order Human Serum AB<\/a>\n      <a href=\"mailto:info@seamlessbio.de\" class=\"ctab2\">Request Plasma \/ Custom Lot<\/a>\n    <\/div>\n  <\/div>\n<\/div>\n\n<script type=\"application\/ld+json\">\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@graph\": [\n    {\n      \"@type\": \"FAQPage\",\n      \"@id\": \"https:\/\/seamlessbio.de\/applications\/human-serum-plasma-ivd-cro#faqpage\",\n      \"mainEntity\": [\n        {\n          \"@type\": \"Question\",\n          \"name\": \"Why Type AB male serum specifically?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Type AB serum contains no ABO antibodies, eliminating interference in immunoassays. 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SeamlessBio supplies Human Serum Type AB and Human Plasma (citrate, apheresis) from EU-sourced, fully documented [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","footnotes":""},"class_list":["post-9226","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Human Serum &amp; Plasma for IVD, CRO &amp; Bioanalytics \u2014 EU Supply<\/title>\n<meta name=\"description\" content=\"Human Serum Type AB and citrate plasma from EU-sourced donors \u2014 for IVD calibration, bioanalytical validation, and CRO applications. 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