{"id":3545,"date":"2026-09-16T12:09:53","date_gmt":"2026-09-16T11:09:53","guid":{"rendered":"https:\/\/seamlessbio.de\/produkt\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/"},"modified":"2026-09-21T15:47:07","modified_gmt":"2026-09-21T14:47:07","slug":"human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions","status":"publish","type":"product","link":"https:\/\/seamlessbio.de\/de\/product\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/","title":{"rendered":"Human MRP4 Vesicle Kit (HEK293 derived) | ABCC4 | Renal &#038; Hepatic Efflux | 100 Reactions"},"content":{"rendered":"<style>\n.sb-pd{font-family:-apple-system,BlinkMacSystemFont,\"Segoe UI\",Roboto,sans-serif;max-width:100%;color:#202020;line-height:1.75}\n.sb-pd .def{background:#e9fbfa;border-left:4px solid #18b7b2;border-radius:0 10px 10px 0;padding:16px 20px;margin:0 0 28px}\n.sb-pd .def .lb{font-size:11px;font-weight:800;text-transform:uppercase;letter-spacing:.09em;color:#139b97;display:block;margin-bottom:5px}\n.sb-pd .def p{font-size:15px;margin:0;font-weight:500}\n.sb-pd h2{font-size:21px;font-weight:800;margin:32px 0 10px;color:#111;border-bottom:2px solid #e2eceb;padding-bottom:7px}\n.sb-pd h3{font-size:15px;font-weight:700;color:#18b7b2;margin:18px 0 5px}\n.sb-pd p{margin:0 0 12px;font-size:15px}\n.sb-pd ul{margin:0 0 12px;padding-left:20px}\n.sb-pd li{margin-bottom:6px;font-size:14px}\n.sb-pd .cards{display:grid;grid-template-columns:repeat(3,1fr);gap:12px;margin:14px 0 20px}\n.sb-pd .card{background:#f1faf9;border:1px solid #daf3f2;border-top:3px solid #18b7b2;border-radius:0 0 10px 10px;padding:14px}\n.sb-pd .card h3{margin:0 0 5px;font-size:13px;color:#111}\n.sb-pd .card p{margin:0;font-size:12px;color:#5b6b71}\n.sb-pd table{width:100%;border-collapse:collapse;font-size:14px;margin:14px 0 20px}\n.sb-pd th{background:#18b7b2;color:#fff;text-align:left;padding:9px 13px;font-weight:700}\n.sb-pd td{padding:9px 13px;border-bottom:1px solid #e2eceb;vertical-align:top}\n.sb-pd tr:nth-child(even) td{background:#f8fffe}\n.sb-pd td:first-child{font-weight:600;color:#111;width:35%}\n.sb-pd .qa{background:#f8fffe;border:1px solid #daf3f2;border-radius:8px;padding:14px 16px;margin:10px 0}\n.sb-pd .qa .q{font-weight:700;color:#111;margin:0 0 5px;font-size:14px}\n.sb-pd .qa .a{margin:0;font-size:13px;color:#444}\n.sb-pd .cta{background:linear-gradient(135deg,#e4f6f5,#f4fbfb);border:1px solid rgba(24,183,178,.2);border-radius:12px;padding:20px;margin-top:28px;text-align:center}\n.sb-pd .cta h3{margin:0 0 7px;font-size:17px;color:#111}\n.sb-pd .cta p{margin:0 0 14px;font-size:13px;color:#5b6b71}\n.sb-pd .btn{display:inline-block;background:#18b7b2;color:#fff!important;padding:9px 20px;border-radius:7px;font-weight:700;font-size:13px;text-decoration:none!important;margin:0 4px}\n.sb-pd .btn-o{display:inline-block;border:2px solid #18b7b2;color:#18b7b2!important;padding:7px 20px;border-radius:7px;font-weight:700;font-size:13px;text-decoration:none!important;margin:0 4px}\n.sb-pd a{color:#18b7b2;font-weight:600}\n@media(max-width:600px){.sb-pd .cards{grid-template-columns:1fr}}\n<\/style>\n<div class=\"sb-pd\">\n<h2>Product Overview<\/h2>\n<p>The <strong>Human MRP4 Vesicle Kit (HEK293)<\/strong> provides ready-to-use inside-out membrane vesicles overexpressing human MRP4 (ABCC4) for ATP-dependent vesicular transport studies. MRP4 is expressed at the apical membrane of renal proximal tubule cells, hepatocyte basolateral membrane, platelets, and the blood-brain barrier. It transports a broad substrate profile including cyclic nucleotides (cAMP, cGMP), prostaglandins, urate, and nucleotide analogue antiviral and anticancer drugs \u2014 making it particularly important for renal DDI risk assessment, antiviral drug development, and platelet biology.<\/p>\n<p>Guaranteed ATP\/AMP transport ratio &gt;5 per lot. Use alongside the <a href=\"https:\/\/seamlessbio.de\/abc-transporter-vesicle-kits\/\">Human Control Vesicle Kit<\/a> for matched background subtraction \u2014 required for regulatory-grade DDI data per FDA DDI Guidance (2020) and EMA DDI Guideline (2013\/2022).<\/p>\n<h2>Transporter Profile<\/h2>\n<table>\n<thead>\n<tr>\n<th>Property<\/th>\n<th>Detail<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Transporter name<\/td>\n<td>MRP4 \u2014 Multidrug Resistance-Associated Protein 4<\/td>\n<\/tr>\n<tr>\n<td>Gene<\/td>\n<td>ABCC4<\/td>\n<\/tr>\n<tr>\n<td>Protein family<\/td>\n<td>ABC transporter, ABCC subfamily<\/td>\n<\/tr>\n<tr>\n<td>Tissue expression<\/td>\n<td>Renal proximal tubule (apical), hepatocyte (basolateral), platelets, blood-brain barrier, lung, prostate<\/td>\n<\/tr>\n<tr>\n<td>Key substrates<\/td>\n<td>cAMP, cGMP, PMEA (adefovir), tenofovir, methotrexate, leucovorin, urate, prostaglandins (PGE\u2081, PGE\u2082), thromboxane B\u2082<\/td>\n<\/tr>\n<tr>\n<td>Inhibitors (reference)<\/td>\n<td>MK571, probenecid, dipyridamole, ceefourin-1<\/td>\n<\/tr>\n<tr>\n<td>DDI relevance<\/td>\n<td>Renal excretion of nucleotide analogues, antiviral nephrotoxicity DDI, methotrexate renal clearance, prostaglandin efflux, platelet cAMP regulation<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Technical Specifications<\/h2>\n<table>\n<thead>\n<tr>\n<th>Parameter<\/th>\n<th>Specification<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Transporter<\/td>\n<td>Human MRP4 (Multidrug Resistance-Associated Protein 4) (ABCC4)<\/td>\n<\/tr>\n<tr>\n<td>Expression system<\/td>\n<td>HEK293 (transient overexpression)<\/td>\n<\/tr>\n<tr>\n<td>Vesicle type<\/td>\n<td>Inside-out membrane vesicles<\/td>\n<\/tr>\n<tr>\n<td>Reactions per kit<\/td>\n<td>100<\/td>\n<\/tr>\n<tr>\n<td>ATP\/AMP transport ratio<\/td>\n<td>&gt;5 (guaranteed per lot)<\/td>\n<\/tr>\n<tr>\n<td>Detection compatibility<\/td>\n<td>Radiolabel, LC-MS\/MS<\/td>\n<\/tr>\n<tr>\n<td>Storage<\/td>\n<td>\u221280 \u00b0C (supplied on dry ice)<\/td>\n<\/tr>\n<tr>\n<td>Kit contents<\/td>\n<td>Vesicles, ATP, AMP, reaction buffer, wash buffer, CoA<\/td>\n<\/tr>\n<tr>\n<td>Manufacturer<\/td>\n<td>Cell4Pharma (Netherlands)<\/td>\n<\/tr>\n<tr>\n<td>Distributor DACH<\/td>\n<td>SeamlessBio GmbH, Passau<\/td>\n<\/tr>\n<tr>\n<td>Regulatory<\/td>\n<td>Research Use Only (RUO)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<table>\n<thead>\n<tr>\n<th>Application<\/th>\n<th>Description<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Antiviral nucleotide analogue renal excretion<\/strong><\/td>\n<td>Nucleotide analogue antivirals \u2014 tenofovir, adefovir (PMEA), cidofovir \u2014 are MRP4 substrates at the renal proximal tubule apical membrane. MRP4 inhibition studies assess DDI risk for renal accumulation and nephrotoxicity in combination antiviral regimens, particularly where co-administered drugs (e.g. probenecid, NSAIDs) inhibit renal MRP4.<\/td>\n<\/tr>\n<tr>\n<td><strong>Renal DDI risk assessment<\/strong><\/td>\n<td>MRP4 mediates active tubular secretion of multiple drug classes into urine. Characterise whether an investigational compound is an MRP4 substrate or inhibitor to predict effects on renal clearance, identify renal accumulation risk, and support dose adjustment guidance for combination therapies.<\/td>\n<\/tr>\n<tr>\n<td><strong>Methotrexate and antifolate transport<\/strong><\/td>\n<td>MRP4 transports methotrexate and leucovorin in the renal proximal tubule. Co-administration of MRP4 inhibitors with high-dose methotrexate can impair tubular secretion, reducing methotrexate clearance and increasing systemic exposure \u2014 relevant for oncology and immunology combination therapy DDI assessment.<\/td>\n<\/tr>\n<tr>\n<td><strong>Prostaglandin and cyclic nucleotide efflux<\/strong><\/td>\n<td>Prostaglandins (PGE\u2081, PGE\u2082) and cyclic nucleotides (cAMP, cGMP) are endogenous MRP4 substrates. In platelets, MRP4-mediated cAMP efflux regulates platelet activation via thromboxane A\u2082 signalling \u2014 inhibition can alter platelet aggregation. Relevant for cardiovascular DDI profiling and anti-inflammatory drug development.<\/td>\n<\/tr>\n<tr>\n<td><strong>Urate excretion and gout DDI<\/strong><\/td>\n<td>MRP4 contributes to renal urate secretion. Drugs that inhibit MRP4-mediated urate efflux in the proximal tubule can raise serum urate levels, increasing gout risk in predisposed patients \u2014 particularly relevant for uricosuric drug development and DDI studies in patients with hyperuricaemia.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Assay Principle<\/h2>\n<p>Inside-out membrane vesicles present the cytoplasmic face of MRP4 to the external assay buffer, allowing ATP-dependent substrate uptake into the vesicle lumen. Vesicles are incubated with test compound and probe substrate in the presence of ATP (active transport condition) or AMP (background control). The reaction is stopped with cold wash buffer; vesicles are separated by rapid filtration and intravesicular substrate is quantified by LC-MS\/MS or radiolabel. The ATP\/AMP uptake ratio \u2014 calculated against matched Human Control Vesicles \u2014 provides the assay window for IC\u2085\u2080 determination and substrate classification.<\/p>\n<h2>Complete Cell4Pharma Kit Portfolio<\/h2>\n<p>Order all ABC transporter vesicle kits from a single EU source \u2014 fast cold-chain delivery, guaranteed ATP\/AMP ratios, full lot documentation.<\/p>\n<table>\n<thead>\n<tr>\n<th>Kit<\/th>\n<th>Transporter<\/th>\n<th>Gene<\/th>\n<th>ATP\/AMP Ratio<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Human BCRP Vesicle Kit<\/td>\n<td>BCRP<\/td>\n<td>ABCG2<\/td>\n<td>&gt;10<\/td>\n<\/tr>\n<tr>\n<td>Human BSEP Vesicle Kit<\/td>\n<td>BSEP<\/td>\n<td>ABCB11<\/td>\n<td>&gt;10<\/td>\n<\/tr>\n<tr>\n<td>Human MRP1 Vesicle Kit<\/td>\n<td>MRP1<\/td>\n<td>ABCC1<\/td>\n<td>&gt;5<\/td>\n<\/tr>\n<tr>\n<td>Human MRP2 Vesicle Kit<\/td>\n<td>MRP2<\/td>\n<td>ABCC2<\/td>\n<td>&gt;20<\/td>\n<\/tr>\n<tr>\n<td>Human MRP3 Vesicle Kit<\/td>\n<td>MRP3<\/td>\n<td>ABCC3<\/td>\n<td>&gt;5<\/td>\n<\/tr>\n<tr>\n<td><strong>Human MRP4 Vesicle Kit<\/strong><\/td>\n<td>MRP4<\/td>\n<td>ABCC4<\/td>\n<td>&gt;5<\/td>\n<\/tr>\n<tr>\n<td>Human MRP5 Vesicle Kit<\/td>\n<td>MRP5<\/td>\n<td>ABCC5<\/td>\n<td>&gt;5<\/td>\n<\/tr>\n<tr>\n<td>Human MRP8 Vesicle Kit<\/td>\n<td>MRP8<\/td>\n<td>ABCC11<\/td>\n<td>&gt;5<\/td>\n<\/tr>\n<tr>\n<td>Human P-gp Vesicle Kit<\/td>\n<td>P-gp \/ MDR1<\/td>\n<td>ABCB1<\/td>\n<td>&gt;5<\/td>\n<\/tr>\n<tr>\n<td>Human P-gp + FluoPgp Kit<\/td>\n<td>P-gp \/ MDR1<\/td>\n<td>ABCB1<\/td>\n<td>&gt;5<\/td>\n<\/tr>\n<tr>\n<td>Human Control Vesicle Kit<\/td>\n<td>\u2014<\/td>\n<td>HEK293 empty vector<\/td>\n<td>\u2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Available Formats<\/h2>\n<table>\n<thead>\n<tr>\n<th>Format<\/th>\n<th>Reactions<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Kit<\/td>\n<td>100 reactions<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Key Benefits<\/h2>\n<div class=\"cards\">\n<div class=\"card\">\n<h3>Batch Reservation<\/h3>\n<p>Reserve validated lots up to 36 months for reproducible long-term DDI study workflows.<\/p>\n<\/div>\n<div class=\"card\">\n<h3>Full Documentation<\/h3>\n<p>Lot-specific QC report and data sheet included with every kit \u2014 from ISO 9001 and ISO 13485 certified partner facilities.<\/p>\n<\/div>\n<div class=\"card\">\n<h3>EU &amp; Swiss Supply<\/h3>\n<p>Manufactured by Cell4Pharma (Netherlands) \u2014 fast cold-chain delivery across EU, UK and Switzerland.<\/p>\n<\/div>\n<\/div>\n<h2>Frequently Asked Questions<\/h2>\n<div class=\"qa\">\n<p class=\"q\">Is MRP4 relevant for specific drug classes in DDI submissions?<\/p>\n<p class=\"a\">Yes \u2014 MRP4 (ABCC4) is most important for three drug classes: (1) nucleotide analogue antivirals (tenofovir, adefovir, cidofovir), where renal MRP4 mediates tubular secretion and inhibition can cause nephrotoxic accumulation; (2) antifolates and cytotoxics (methotrexate, leucovorin), where MRP4 inhibition reduces renal clearance and increases systemic exposure; and (3) NSAIDs and COX inhibitors, which can inhibit MRP4-mediated prostaglandin efflux and alter renal and platelet physiology. MRP4 is not currently a primary Tier 1 DDI transporter under FDA (2020) or EMA (2022) guidance, but it is routinely included in extended renal transporter panels alongside OAT1, OAT3, and OCT2 for the drug classes above.<\/p>\n<\/div>\n<div class=\"qa\">\n<p class=\"q\">What probe substrates and inhibitors are used in MRP4 vesicular transport assays?<\/p>\n<p class=\"a\">The most commonly used radiolabelled probe substrates for MRP4 (ABCC4) vesicular transport assays are [\u00b3H]-PMEA (adefovir dipivoxil precursor) and [\u00b3H]-methotrexate; unlabelled cAMP and estradiol-17\u03b2-D-glucuronide (E217\u03b2G) are also used with LC-MS\/MS detection. For inhibition studies, reference inhibitors include MK571 (pan-MRP inhibitor), probenecid, dipyridamole, and the selective MRP4 inhibitor ceefourin-1. The Cell4Pharma kit protocol provides lot-specific recommendations for probe substrate concentration and incubation conditions to achieve the guaranteed ATP\/AMP ratio of &gt;5.<\/p>\n<\/div>\n<div class=\"qa\">\n<p class=\"q\">How does MRP4 contribute to antiviral nephrotoxicity, and how does the vesicle assay help?<\/p>\n<p class=\"a\">Nucleotide analogue antivirals such as tenofovir and adefovir are renally excreted primarily via active tubular secretion, which requires uptake from blood into the tubular cell (mediated by OAT1\/OAT3 at the basolateral membrane) followed by efflux into urine (mediated by MRP4 at the apical membrane). When MRP4 is inhibited \u2014 by a co-administered drug or by the antiviral itself at high doses \u2014 the drug accumulates intracellularly in proximal tubule cells, causing mitochondrial toxicity and nephrotoxicity. The MRP4 vesicle assay quantifies the IC\u2085\u2080 of a test compound for MRP4-mediated efflux of probe substrate (e.g. PMEA), enabling DDI risk assessment and informing whether dose adjustment or renal monitoring is warranted in combination regimens.<\/p>\n<\/div>\n<div class=\"qa\">\n<p class=\"q\">Why is MRP4 relevant in platelet biology and cardiovascular DDI studies?<\/p>\n<p class=\"a\">MRP4 (ABCC4) is expressed at high levels in platelets, where it mediates efflux of cAMP and thromboxane B\u2082. Intracellular cAMP in platelets acts as an inhibitory second messenger, suppressing platelet activation and aggregation \u2014 MRP4 efflux reduces intracellular cAMP, thereby supporting the platelet activation threshold. Inhibition of platelet MRP4 by drugs such as dipyridamole raises intracellular cAMP and inhibits platelet aggregation, contributing to the antiplatelet mechanism of this compound class. For investigational drugs where platelet effects or cardiovascular DDI are a concern, including MRP4 in the transporter profiling panel helps characterise this mechanism.<\/p>\n<\/div>\n<div class=\"qa\">\n<p class=\"q\">What documentation is supplied with the Human MRP4 Vesicle Kit?<\/p>\n<p class=\"a\">Every kit shipment includes a lot-specific QC report confirming the ATP\/AMP transport ratio (&gt;5) and vesicle preparation parameters, and a data sheet with recommended assay conditions, probe substrates, and reference inhibitor concentrations. All Cell4Pharma kits are manufactured under ISO 9001 and ISO 13485 certified quality systems. Batch reservation for up to 36 months is available on request \u2014 particularly important for multi-transporter renal DDI panels where lot-to-lot consistency between the MRP4 kit and matched Control Vesicle Kit must be maintained across the full study duration.<\/p>\n<\/div>\n<div class=\"cta\">\n<h3>Request a Quote or Sample<\/h3>\n<p>48h response \u00b7 EU &amp; Swiss Supply \u00b7 Batch reservation available \u00b7 Full documentation<\/p>\n<p>  <a href=\"https:\/\/seamlessbio.de\/request-quote\/\" class=\"btn\">Request Quote \u2192<\/a><br \/>\n  <a href=\"https:\/\/seamlessbio.de\/abc-transporter-vesicle-kits\/\" class=\"btn-o\">All ABC Transporter Kits \u2192<\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Human MRP4 Vesicle Kit (HEK293 derived) | ABCC4 | Renal &#038; Hepatic Efflux | 100 Reactions. Available in 100. Price on request \u2014 contact our team for availability, batch documentation and delivery. <\/p>\n<div style='margin-top:12px'><a href='https:\/\/seamlessbio.de\/de\/sammelreservierung\/' style='display:block;background:#fff;border:2px solid #18b7b2;color:#18b7b2;padding:10px 24px;border-radius:8px;font-weight:700;font-size:14px;text-decoration:none;text-align:center;'>Test Sample &amp; Batch Reservation \u2192<\/a><\/div>","protected":false},"featured_media":3704,"template":"","meta":{"_eb_attr":""},"product_brand":[],"product_cat":[73],"product_tag":[58],"class_list":["post-3545","product","type-product","status-publish","has-post-thumbnail","product_cat-dmpk-transporter-kits","product_tag-cell-culture","first","instock","taxable","shipping-taxable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>MRP4 Vesicle Kit | Renal Efflux DMPK | SeamlessBio<\/title>\n<meta name=\"description\" content=\"MRP4 ABCC4 HEK293 inside-out vesicle kit. FDA DDI renal tubular efflux for antivirals and NSAIDs. **100 reactions per kit.**\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/seamlessbio.de\/de\/produkt\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MRP4 Vesicle Kit | Renal Efflux DMPK | SeamlessBio\" \/>\n<meta property=\"og:description\" content=\"MRP4 ABCC4 HEK293 inside-out vesicle kit. FDA DDI renal tubular efflux for antivirals and NSAIDs. **100 reactions per kit.**\" \/>\n<meta property=\"og:url\" content=\"https:\/\/seamlessbio.de\/de\/produkt\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/\" \/>\n<meta property=\"og:site_name\" content=\"SeamlessBio\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-21T14:47:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/seamlessbio.de\/wp-content\/uploads\/2026\/09\/ciptec-cell-line-seamlessbio-1024x768.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"768\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"4\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/product\\\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\\\/\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/product\\\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\\\/\",\"name\":\"MRP4 Vesicle Kit | Renal Efflux DMPK | SeamlessBio\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/product\\\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/product\\\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/seamlessbio.de\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/ciptec-cell-line-seamlessbio.jpg\",\"datePublished\":\"2026-09-16T11:09:53+00:00\",\"dateModified\":\"2026-09-21T14:47:07+00:00\",\"description\":\"MRP4 ABCC4 HEK293 inside-out vesicle kit. FDA DDI renal tubular efflux for antivirals and NSAIDs. **100 reactions per kit.**\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/product\\\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\\\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/seamlessbio.de\\\/product\\\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/product\\\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\\\/#primaryimage\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/ciptec-cell-line-seamlessbio.jpg\",\"contentUrl\":\"https:\\\/\\\/seamlessbio.de\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/ciptec-cell-line-seamlessbio.jpg\",\"width\":2560,\"height\":1920,\"caption\":\"MRP5 vesicle kit ABCC5\"},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#website\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/\",\"name\":\"SeamlessBio\",\"description\":\"Expert for biological materials for pharma, vaccines and research organizations\",\"publisher\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/seamlessbio.de\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"de\"},{\"@type\":[\"Organization\",\"Place\",\"ProfessionalService\"],\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/#organization\",\"name\":\"SeamlessBio\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/\",\"logo\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/product\\\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\\\/#local-main-organization-logo\"},\"image\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/product\\\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\\\/#local-main-organization-logo\"},\"address\":{\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/product\\\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\\\/#local-main-place-address\"},\"telephone\":[\"+49 (851) 37932226\"],\"contactPoint\":{\"@type\":\"ContactPoint\",\"telephone\":\"+49 (851) 37932226\",\"email\":\"info@seamlessbio.de\"},\"openingHoursSpecification\":[{\"@type\":\"OpeningHoursSpecification\",\"dayOfWeek\":[\"Monday\",\"Tuesday\",\"Wednesday\",\"Thursday\",\"Friday\"],\"opens\":\"09:00\",\"closes\":\"17:00\"},{\"@type\":\"OpeningHoursSpecification\",\"dayOfWeek\":[\"Saturday\",\"Sunday\"],\"opens\":\"00:00\",\"closes\":\"00:00\"}],\"email\":\"info@seamlessbio.de\"},{\"@type\":\"PostalAddress\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/product\\\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\\\/#local-main-place-address\",\"streetAddress\":\"Dr.-Ernst-Derra-Str. 4\",\"addressLocality\":\"Passau\",\"postalCode\":\"94036\",\"addressRegion\":\"Bavaria\",\"addressCountry\":\"DE\"},{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\\\/\\\/seamlessbio.de\\\/product\\\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\\\/#local-main-organization-logo\",\"url\":\"https:\\\/\\\/seamlessbio.de\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/134428046-2.png\",\"contentUrl\":\"https:\\\/\\\/seamlessbio.de\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/134428046-2.png\",\"width\":973,\"height\":288,\"caption\":\"SeamlessBio\"}]}<\/script>\n<meta name=\"geo.placename\" content=\"Passau\" \/>\n<meta name=\"geo.region\" content=\"Deutschland\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"MRP4 Vesicle Kit | Renal Efflux DMPK | SeamlessBio","description":"MRP4 ABCC4 HEK293 inside-out vesicle kit. FDA DDI renal tubular efflux for antivirals and NSAIDs. **100 reactions per kit.**","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/seamlessbio.de\/de\/produkt\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/","og_locale":"de_DE","og_type":"article","og_title":"MRP4 Vesicle Kit | Renal Efflux DMPK | SeamlessBio","og_description":"MRP4 ABCC4 HEK293 inside-out vesicle kit. FDA DDI renal tubular efflux for antivirals and NSAIDs. **100 reactions per kit.**","og_url":"https:\/\/seamlessbio.de\/de\/produkt\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/","og_site_name":"SeamlessBio","article_modified_time":"2026-09-21T14:47:07+00:00","og_image":[{"width":1024,"height":768,"url":"https:\/\/seamlessbio.de\/wp-content\/uploads\/2026\/09\/ciptec-cell-line-seamlessbio-1024x768.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Gesch\u00e4tzte Lesezeit":"4\u00a0Minuten"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/seamlessbio.de\/product\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/","url":"https:\/\/seamlessbio.de\/product\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/","name":"MRP4 Vesicle Kit | Renal Efflux DMPK | SeamlessBio","isPartOf":{"@id":"https:\/\/seamlessbio.de\/#website"},"primaryImageOfPage":{"@id":"https:\/\/seamlessbio.de\/product\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/#primaryimage"},"image":{"@id":"https:\/\/seamlessbio.de\/product\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/#primaryimage"},"thumbnailUrl":"https:\/\/seamlessbio.de\/wp-content\/uploads\/2026\/09\/ciptec-cell-line-seamlessbio.jpg","datePublished":"2026-09-16T11:09:53+00:00","dateModified":"2026-09-21T14:47:07+00:00","description":"MRP4 ABCC4 HEK293 inside-out vesicle kit. FDA DDI renal tubular efflux for antivirals and NSAIDs. **100 reactions per kit.**","breadcrumb":{"@id":"https:\/\/seamlessbio.de\/product\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/#breadcrumb"},"inLanguage":"de","potentialAction":[{"@type":"ReadAction","target":["https:\/\/seamlessbio.de\/product\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/"]}]},{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/seamlessbio.de\/product\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/#primaryimage","url":"https:\/\/seamlessbio.de\/wp-content\/uploads\/2026\/09\/ciptec-cell-line-seamlessbio.jpg","contentUrl":"https:\/\/seamlessbio.de\/wp-content\/uploads\/2026\/09\/ciptec-cell-line-seamlessbio.jpg","width":2560,"height":1920,"caption":"MRP5 vesicle kit ABCC5"},{"@type":"WebSite","@id":"https:\/\/seamlessbio.de\/#website","url":"https:\/\/seamlessbio.de\/","name":"SeamlessBio","description":"Experte f\u00fcr biologische Materialien f\u00fcr die Pharmaindustrie, Impfstoffe und Forschungseinrichtungen","publisher":{"@id":"https:\/\/seamlessbio.de\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/seamlessbio.de\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"de"},{"@type":["Organization","Place","ProfessionalService"],"@id":"https:\/\/seamlessbio.de\/#organization","name":"SeamlessBio","url":"https:\/\/seamlessbio.de\/","logo":{"@id":"https:\/\/seamlessbio.de\/product\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/#local-main-organization-logo"},"image":{"@id":"https:\/\/seamlessbio.de\/product\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/#local-main-organization-logo"},"address":{"@id":"https:\/\/seamlessbio.de\/product\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/#local-main-place-address"},"telephone":["+49 (851) 37932226"],"contactPoint":{"@type":"ContactPoint","telephone":"+49 (851) 37932226","email":"info@seamlessbio.de"},"openingHoursSpecification":[{"@type":"OpeningHoursSpecification","dayOfWeek":["Monday","Tuesday","Wednesday","Thursday","Friday"],"opens":"09:00","closes":"17:00"},{"@type":"OpeningHoursSpecification","dayOfWeek":["Saturday","Sunday"],"opens":"00:00","closes":"00:00"}],"email":"info@seamlessbio.de"},{"@type":"PostalAddress","@id":"https:\/\/seamlessbio.de\/product\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/#local-main-place-address","streetAddress":"Dr.-Ernst-Derra-Str. 4","addressLocality":"Passau","postalCode":"94036","addressRegion":"Bavaria","addressCountry":"DE"},{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/seamlessbio.de\/product\/human-mrp4-vesicle-kit-hek293-derived-abcc4-renal-hepatic-efflux-100-reactions\/#local-main-organization-logo","url":"https:\/\/seamlessbio.de\/wp-content\/uploads\/2026\/04\/134428046-2.png","contentUrl":"https:\/\/seamlessbio.de\/wp-content\/uploads\/2026\/04\/134428046-2.png","width":973,"height":288,"caption":"SeamlessBio"}]},"geo.placename":"Passau","geo.region":"Deutschland"},"_links":{"self":[{"href":"https:\/\/seamlessbio.de\/de\/wp-json\/wp\/v2\/product\/3545","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/seamlessbio.de\/de\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/seamlessbio.de\/de\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/seamlessbio.de\/de\/wp-json\/wp\/v2\/media\/3704"}],"wp:attachment":[{"href":"https:\/\/seamlessbio.de\/de\/wp-json\/wp\/v2\/media?parent=3545"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/seamlessbio.de\/de\/wp-json\/wp\/v2\/product_brand?post=3545"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/seamlessbio.de\/de\/wp-json\/wp\/v2\/product_cat?post=3545"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/seamlessbio.de\/de\/wp-json\/wp\/v2\/product_tag?post=3545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}