{"id":3546,"date":"2026-09-16T12:09:53","date_gmt":"2026-09-16T11:09:53","guid":{"rendered":"https:\/\/seamlessbio.de\/produkt\/human-mrp3-vesicle-kit-hek293-derived-abcc3-hepatic-basolateral-efflux-100-reactions\/"},"modified":"2026-09-21T15:22:46","modified_gmt":"2026-09-21T14:22:46","slug":"human-mrp3-vesicle-kit-hek293-derived-abcc3-hepatic-basolateral-efflux-100-reactions","status":"publish","type":"product","link":"https:\/\/seamlessbio.de\/de\/product\/human-mrp3-vesicle-kit-hek293-derived-abcc3-hepatic-basolateral-efflux-100-reactions\/","title":{"rendered":"Human MRP3 Vesicle Kit (HEK293 derived) | 100 Reactions"},"content":{"rendered":"<style>\n.sb-pd{font-family:-apple-system,BlinkMacSystemFont,\"Segoe UI\",Roboto,sans-serif;max-width:100%;color:#202020;line-height:1.75}\n.sb-pd .def{background:#e9fbfa;border-left:4px solid #18b7b2;border-radius:0 10px 10px 0;padding:16px 20px;margin:0 0 28px}\n.sb-pd .def .lb{font-size:11px;font-weight:800;text-transform:uppercase;letter-spacing:.09em;color:#139b97;display:block;margin-bottom:5px}\n.sb-pd .def p{font-size:15px;margin:0;font-weight:500}\n.sb-pd h2{font-size:21px;font-weight:800;margin:32px 0 10px;color:#111;border-bottom:2px solid #e2eceb;padding-bottom:7px}\n.sb-pd h3{font-size:15px;font-weight:700;color:#18b7b2;margin:18px 0 5px}\n.sb-pd p{margin:0 0 12px;font-size:15px}\n.sb-pd ul{margin:0 0 12px;padding-left:20px}\n.sb-pd li{margin-bottom:6px;font-size:14px}\n.sb-pd .cards{display:grid;grid-template-columns:repeat(3,1fr);gap:12px;margin:14px 0 20px}\n.sb-pd .card{background:#f1faf9;border:1px solid #daf3f2;border-top:3px solid #18b7b2;border-radius:0 0 10px 10px;padding:14px}\n.sb-pd .card h3{margin:0 0 5px;font-size:13px;color:#111}\n.sb-pd .card p{margin:0;font-size:12px;color:#5b6b71}\n.sb-pd table{width:100%;border-collapse:collapse;font-size:14px;margin:14px 0 20px}\n.sb-pd th{background:#18b7b2;color:#fff;text-align:left;padding:9px 13px;font-weight:700}\n.sb-pd td{padding:9px 13px;border-bottom:1px solid #e2eceb;vertical-align:top}\n.sb-pd tr:nth-child(even) td{background:#f8fffe}\n.sb-pd td:first-child{font-weight:600;color:#111;width:35%}\n.sb-pd .qa{background:#f8fffe;border:1px solid #daf3f2;border-radius:8px;padding:14px 16px;margin:10px 0}\n.sb-pd .qa .q{font-weight:700;color:#111;margin:0 0 5px;font-size:14px}\n.sb-pd .qa .a{margin:0;font-size:13px;color:#444}\n.sb-pd .cta{background:linear-gradient(135deg,#e4f6f5,#f4fbfb);border:1px solid rgba(24,183,178,.2);border-radius:12px;padding:20px;margin-top:28px;text-align:center}\n.sb-pd .cta h3{margin:0 0 7px;font-size:17px;color:#111}\n.sb-pd .cta p{margin:0 0 14px;font-size:13px;color:#5b6b71}\n.sb-pd .btn{display:inline-block;background:#18b7b2;color:#fff!important;padding:9px 20px;border-radius:7px;font-weight:700;font-size:13px;text-decoration:none!important;margin:0 4px}\n.sb-pd .btn-o{display:inline-block;border:2px solid #18b7b2;color:#18b7b2!important;padding:7px 20px;border-radius:7px;font-weight:700;font-size:13px;text-decoration:none!important;margin:0 4px}\n.sb-pd a{color:#18b7b2;font-weight:600}\n@media(max-width:600px){.sb-pd .cards{grid-template-columns:1fr}}\n<\/style>\n<div class=\"sb-pd\">\n<h2>Product Overview<\/h2>\n<p>The <strong>Human MRP3 Vesicle Kit (HEK293)<\/strong> provides ready-to-use inside-out membrane vesicles overexpressing human MRP3 (ABCC3) for ATP-dependent vesicular transport studies. MRP3 is localised at the basolateral (sinusoidal) membrane of hepatocytes \u2014 the opposite face from canalicular BSEP and MRP2 \u2014 where it pumps glucuronide conjugates and monovalent bile acids from the hepatocyte into sinusoidal blood. This makes MRP3 a key determinant of hepatic drug disposition and the primary overflow pathway for bile acids during cholestasis.<\/p>\n<p>Guaranteed ATP\/AMP transport ratio &gt;5 per lot. Use alongside the <a href=\"https:\/\/seamlessbio.de\/de\/abc-transporter-vesicle-kits\/\">Kit f\u00fcr Human-Kontrollvesikel<\/a> for matched background subtraction \u2014 required for regulatory-grade DDI data per FDA DDI Guidance (2020) and EMA DDI Guideline (2013\/2022).<\/p>\n<h2>Transporter Profile<\/h2>\n<table>\n<thead>\n<tr>\n<th>Eigenschaft<\/th>\n<th>Detail<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Transporter name<\/td>\n<td>MRP3 \u2014 Multidrug Resistance-Associated Protein 3<\/td>\n<\/tr>\n<tr>\n<td>Gen<\/td>\n<td>ABCC3<\/td>\n<\/tr>\n<tr>\n<td>Protein family<\/td>\n<td>ABC transporter, ABCC subfamily<\/td>\n<\/tr>\n<tr>\n<td>Membrane localisation<\/td>\n<td>Basolateral (sinusoidal) membrane of hepatocytes; also intestinal epithelium, kidney<\/td>\n<\/tr>\n<tr>\n<td>Key substrates<\/td>\n<td>Glucuronide conjugates, monoanionic bile salts, methotrexate, etoposide<\/td>\n<\/tr>\n<tr>\n<td>Inhibitors (reference)<\/td>\n<td>MK571, probenecid<\/td>\n<\/tr>\n<tr>\n<td>DDI relevance<\/td>\n<td>Hepatic metabolite efflux, cholestatic bile acid overflow, intestinal phase II metabolite transport, enterohepatic circulation<\/td>\n<\/tr>\n<tr>\n<td>Compensatory role<\/td>\n<td>MRP3 is upregulated as a compensatory mechanism when canalicular BSEP-mediated secretion is impaired<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Technische Daten<\/h2>\n<table>\n<thead>\n<tr>\n<th>Parameter<\/th>\n<th>Spezifikation<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Transporter<\/td>\n<td>Human MRP3 (Multidrug Resistance-Associated Protein 3) (ABCC3)<\/td>\n<\/tr>\n<tr>\n<td>Expressionssystem<\/td>\n<td>HEK293 (transient overexpression)<\/td>\n<\/tr>\n<tr>\n<td>Vesicle type<\/td>\n<td>Inside-out membrane vesicles<\/td>\n<\/tr>\n<tr>\n<td>Reaktionen pro Kit<\/td>\n<td>100<\/td>\n<\/tr>\n<tr>\n<td>ATP\/AMP transport ratio<\/td>\n<td>&gt;5 (guaranteed per lot)<\/td>\n<\/tr>\n<tr>\n<td>Detection compatibility<\/td>\n<td>Radiolabel, LC-MS\/MS<\/td>\n<\/tr>\n<tr>\n<td>Lagerung<\/td>\n<td>\u221280 \u00b0C (supplied on dry ice)<\/td>\n<\/tr>\n<tr>\n<td>Kit contents<\/td>\n<td>Vesicles, ATP, AMP, reaction buffer, wash buffer, CoA<\/td>\n<\/tr>\n<tr>\n<td>Manufacturer<\/td>\n<td>Cell4Pharma (Netherlands)<\/td>\n<\/tr>\n<tr>\n<td>Distributor DACH<\/td>\n<td>SeamlessBio GmbH, Passau<\/td>\n<\/tr>\n<tr>\n<td>Regulatorisch<\/td>\n<td>Research Use Only (RUO)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Anwendungen<\/h2>\n<table>\n<thead>\n<tr>\n<th>Anwendung<\/th>\n<th>Description<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Hepatic basolateral efflux profiling<\/strong><\/td>\n<td>Characterise MRP3-mediated sinusoidal export of glucuronide drug conjugates \u2014 relevant for predicting hepatic drug accumulation and systemic exposure of phase II metabolites. Particularly important for compounds with extensive hepatic glucuronidation where metabolite fate determines overall PK.<\/td>\n<\/tr>\n<tr>\n<td><strong>Cholestasis-related bile acid transport<\/strong><\/td>\n<td>Evaluate bile acid overflow through MRP3 as a compensatory mechanism when canalicular BSEP-mediated secretion is impaired. Relevant for BSEP inhibitor DDI studies and for understanding hepatotoxic liability in compounds that disrupt bile acid homeostasis.<\/td>\n<\/tr>\n<tr>\n<td><strong>BSEP\/MRP3 interaction panel<\/strong><\/td>\n<td>MRP3 and BSEP act as functional counterparts in hepatic bile acid handling. Running MRP3 alongside BSEP and MRP2 in a cholestasis DDI panel enables a complete picture of hepatocyte bile acid flux and identifies whether compounds that inhibit BSEP also suppress the MRP3 safety valve.<\/td>\n<\/tr>\n<tr>\n<td><strong>Intestinal drug efflux studies<\/strong><\/td>\n<td>MRP3 at the intestinal basolateral membrane contributes to mucosal-to-serosal transport of phase II metabolites. Relevant for compounds with significant intestinal glucuronidation where basolateral efflux drives oral bioavailability of metabolites and enterohepatic cycling.<\/td>\n<\/tr>\n<tr>\n<td><strong>Methotrexate and cytotoxic transport<\/strong><\/td>\n<td>MRP3 transports methotrexate and etoposide \u2014 cytotoxic drugs where hepatic and intestinal efflux affect tissue exposure and systemic clearance. Relevant for DDI assessment of investigational compounds co-administered with methotrexate-based chemotherapy regimens.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Assay Principle<\/h2>\n<p>Inside-out membrane vesicles present the cytoplasmic face of MRP3 to the external assay buffer, allowing ATP-dependent substrate uptake into the vesicle lumen. Vesicles are incubated with test compound and probe substrate in the presence of ATP (active transport condition) or AMP (background control). The reaction is stopped with cold wash buffer; vesicles are separated by rapid filtration and intravesicular substrate is quantified by LC-MS\/MS or radiolabel. The ATP\/AMP uptake ratio \u2014 calculated against matched Human Control Vesicles \u2014 provides the assay window for IC\u2085\u2080 determination and substrate classification.<\/p>\n<h2>Complete Cell4Pharma Kit Portfolio<\/h2>\n<p>Order all ABC transporter vesicle kits from a single EU source \u2014 fast cold-chain delivery, guaranteed ATP\/AMP ratios, full lot documentation.<\/p>\n<table>\n<thead>\n<tr>\n<th>Bausatz<\/th>\n<th>Transporter<\/th>\n<th>Gen<\/th>\n<th>ATP\/AMP Ratio<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Kit f\u00fcr menschliche BCRP-Vesikel<\/td>\n<td>BCRP<\/td>\n<td>ABCG2<\/td>\n<td>&gt;10<\/td>\n<\/tr>\n<tr>\n<td>BSEP-Vesikel-Kit f\u00fcr den Menschen<\/td>\n<td>BSEP<\/td>\n<td>ABCB11<\/td>\n<td>&gt;10<\/td>\n<\/tr>\n<tr>\n<td>MRP1-Vesikel-Kit f\u00fcr den Menschen<\/td>\n<td>MRP1<\/td>\n<td>ABCC1<\/td>\n<td>&gt;5<\/td>\n<\/tr>\n<tr>\n<td>MRP2-Vesikel-Kit f\u00fcr den Menschen<\/td>\n<td>MRP2<\/td>\n<td>ABCC2<\/td>\n<td>&gt;20<\/td>\n<\/tr>\n<tr>\n<td><strong>MRP3-Vesikel-Kit f\u00fcr den Menschen<\/strong><\/td>\n<td>MRP3<\/td>\n<td>ABCC3<\/td>\n<td>&gt;5<\/td>\n<\/tr>\n<tr>\n<td>MRP4-Vesikel-Kit f\u00fcr den Menschen<\/td>\n<td>MRP4<\/td>\n<td>ABCC4<\/td>\n<td>&gt;5<\/td>\n<\/tr>\n<tr>\n<td>MRP5-Vesikel-Kit f\u00fcr den Menschen<\/td>\n<td>MRP5<\/td>\n<td>ABCC5<\/td>\n<td>&gt;5<\/td>\n<\/tr>\n<tr>\n<td>MRP8-Vesikel-Kit (menschlich)<\/td>\n<td>MRP8<\/td>\n<td>ABCC11<\/td>\n<td>&gt;5<\/td>\n<\/tr>\n<tr>\n<td>Kit f\u00fcr menschliche P-gp-Vesikel<\/td>\n<td>P-gp \/ MDR1<\/td>\n<td>ABCB1<\/td>\n<td>&gt;5<\/td>\n<\/tr>\n<tr>\n<td>Human P-gp + FluoPgp Kit<\/td>\n<td>P-gp \/ MDR1<\/td>\n<td>ABCB1<\/td>\n<td>&gt;5<\/td>\n<\/tr>\n<tr>\n<td>Kit f\u00fcr Human-Kontrollvesikel<\/td>\n<td>\u2014<\/td>\n<td>HEK293 empty vector<\/td>\n<td>\u2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Available Formats<\/h2>\n<table>\n<thead>\n<tr>\n<th>Format<\/th>\n<th>Reactions<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Bausatz<\/td>\n<td>100 Reaktionen<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Key Benefits<\/h2>\n<div class=\"cards\">\n<div class=\"card\">\n<h3>Sammelreservierung<\/h3>\n<p>Reserve validated lots up to 36 months for reproducible long-term DDI study workflows.<\/p>\n<\/div>\n<div class=\"card\">\n<h3>Vollst\u00e4ndige Dokumentation<\/h3>\n<p>Lot-specific QC report and data sheet included with every kit \u2014 from ISO 9001 and ISO 13485 certified partner facilities.<\/p>\n<\/div>\n<div class=\"card\">\n<h3>EU &amp; Swiss Supply<\/h3>\n<p>Manufactured by Cell4Pharma (Netherlands) \u2014 fast cold-chain delivery across EU, UK and Switzerland.<\/p>\n<\/div>\n<\/div>\n<h2>H\u00e4ufig gestellte Fragen<\/h2>\n<div class=\"qa\">\n<p class=\"q\">When should MRP3 be included in a transporter profiling panel?<\/p>\n<p class=\"a\">MRP3 is particularly valuable in three scenarios: (1) compounds with extensive hepatic glucuronidation, where you need to understand the sinusoidal export route for glucuronide metabolites and their systemic exposure; (2) BSEP inhibitors, where cholestatic bile acid overflow through MRP3 is the primary compensatory mechanism and must be characterised to assess net hepatotoxic risk; and (3) compounds with significant enterohepatic circulation, where intestinal MRP3 activity affects the mucosal-to-serosal transport of phase II metabolites. MRP3 is also included when the compound structurally resembles known MRP3 substrates such as methotrexate, etoposide, or monoanionic bile salts.<\/p>\n<\/div>\n<div class=\"qa\">\n<p class=\"q\">What is the relationship between MRP3 and BSEP in cholestasis DDI studies?<\/p>\n<p class=\"a\">BSEP (ABCB11) and MRP3 (ABCC3) serve complementary roles in hepatic bile acid handling. Under normal conditions, BSEP mediates canalicular secretion of conjugated bile acids into bile. When BSEP function is impaired \u2014 by drug inhibition or genetic variation \u2014 bile acids accumulate intracellularly and drive upregulation of MRP3 at the basolateral membrane, redirecting bile acid efflux into sinusoidal blood as a compensatory overflow mechanism. In BSEP DDI studies, characterising MRP3 activity alongside BSEP is important: a compound that strongly inhibits BSEP while also inhibiting MRP3 removes both export routes simultaneously, substantially increasing hepatocyte bile acid accumulation and cholestatic injury risk. Running both assays in parallel gives a more complete picture of net hepatic bile acid flux.<\/p>\n<\/div>\n<div class=\"qa\">\n<p class=\"q\">What substrates and probe substrates are used in MRP3 vesicular transport assays?<\/p>\n<p class=\"a\">Well-characterised MRP3 (ABCC3) substrates for vesicular transport assays include estradiol-17\u03b2-D-glucuronide (E217\u03b2G) \u2014 the most commonly used radiolabelled probe substrate \u2014 as well as taurolithocholate-3-sulfate (TLCS), methotrexate, etoposide glucuronide, and monoanionic bile acids such as glycocholate. For inhibition studies, reference inhibitors include MK571 (pan-MRP inhibitor) and probenecid. The Cell4Pharma kit protocol provides lot-specific recommendations for probe substrate concentration and incubation conditions to achieve the guaranteed ATP\/AMP ratio of &gt;5.<\/p>\n<\/div>\n<div class=\"qa\">\n<p class=\"q\">How does MRP3 differ from MRP2, and why are both relevant in hepatic DDI panels?<\/p>\n<p class=\"a\">MRP2 (ABCC2) and MRP3 (ABCC3) share significant substrate overlap \u2014 both transport glucuronide conjugates and bile salts \u2014 but are localised on opposite faces of the hepatocyte. MRP2 sits at the canalicular (apical) membrane and drives substrate secretion into bile, while MRP3 sits at the basolateral (sinusoidal) membrane and redirects substrates into the portal circulation. This opposing polarity means the two transporters compete for the same hepatocellular substrate pool and together determine whether a glucuronide conjugate exits via bile or systemic blood. For DDI risk assessment of compounds that undergo hepatic glucuronidation, characterising both MRP2-mediated biliary excretion and MRP3-mediated sinusoidal efflux provides the complete picture of hepatic clearance routes and metabolite systemic exposure.<\/p>\n<\/div>\n<div class=\"qa\">\n<p class=\"q\">What documentation is supplied with the Human MRP3 Vesicle Kit?<\/p>\n<p class=\"a\">Every kit shipment includes a lot-specific QC report confirming the ATP\/AMP transport ratio (&gt;5) and vesicle preparation parameters, and a data sheet with recommended assay conditions, probe substrates, and reference inhibitor concentrations. All Cell4Pharma kits are manufactured under ISO 9001 and ISO 13485 certified quality systems. Batch reservation for up to 36 months is available on request \u2014 particularly important for multi-transporter DDI panels where lot-to-lot consistency between the MRP3 kit and matched Control Vesicle Kit must be maintained across the full study duration.<\/p>\n<\/div>\n<div class=\"cta\">\n<h3>Request a Quote or Sample<\/h3>\n<p>48h response \u00b7 EU &amp; Swiss Supply \u00b7 Batch reservation available \u00b7 Full documentation<\/p>\n<p>  <a href=\"https:\/\/seamlessbio.de\/de\/request-quote\/\" class=\"btn\">Request Quote \u2192<\/a><br \/>\n  <a href=\"https:\/\/seamlessbio.de\/de\/abc-transporter-vesicle-kits\/\" class=\"btn-o\">All ABC Transporter Kits \u2192<\/a>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Human MRP3 Vesicle Kit (HEK293 derived) | ABCC3 | Hepatic Basolateral Efflux | 100 Reactions. Available in 100. Price on request \u2014 contact our team for availability, batch documentation and delivery. <\/p>\n<div style='margin-top:12px'><a href='https:\/\/seamlessbio.de\/de\/sammelreservierung\/' style='display:block;background:#fff;border:2px solid #18b7b2;color:#18b7b2;padding:10px 24px;border-radius:8px;font-weight:700;font-size:14px;text-decoration:none;text-align:center;'>Test Sample &amp; Batch Reservation \u2192<\/a><\/div>","protected":false},"featured_media":3704,"template":"","meta":{"_eb_attr":""},"product_brand":[],"product_cat":[73],"product_tag":[58],"class_list":["post-3546","product","type-product","status-publish","has-post-thumbnail","product_cat-dmpk-transporter-kits","product_tag-cell-culture","first","instock","taxable","shipping-taxable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>MRP3 Vesicle Kit | ABCC3 DDI Assay | SeamlessBio<\/title>\n<meta name=\"description\" content=\"MRP3 ABCC3 HEK293 inside-out vesicle kit. 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