{"id":3559,"date":"2026-09-16T12:09:59","date_gmt":"2026-09-16T11:09:59","guid":{"rendered":"https:\/\/seamlessbio.de\/produkt\/human-bsep-vesicle-kit-hek293-derived\/"},"modified":"2026-09-22T16:23:47","modified_gmt":"2026-09-22T15:23:47","slug":"human-bsep-vesicle-kit-hek293-derived","status":"publish","type":"product","link":"https:\/\/seamlessbio.de\/de\/product\/human-bsep-vesicle-kit-hek293-derived\/","title":{"rendered":"Human BSEP Vesicle Kit (HEK293-derived)"},"content":{"rendered":"<style>\n.sb-pd{font-family:-apple-system,BlinkMacSystemFont,\"Segoe UI\",Roboto,sans-serif;max-width:100%;color:#202020;line-height:1.75}\n.sb-pd .def{background:#e9fbfa;border-left:4px solid #18b7b2;border-radius:0 10px 10px 0;padding:16px 20px;margin:0 0 28px}\n.sb-pd .def .lb{font-size:11px;font-weight:800;text-transform:uppercase;letter-spacing:.09em;color:#139b97;display:block;margin-bottom:5px}\n.sb-pd .def p{font-size:15px;margin:0;font-weight:500}\n.sb-pd h2{font-size:21px;font-weight:800;margin:32px 0 10px;color:#111;border-bottom:2px solid #e2eceb;padding-bottom:7px}\n.sb-pd h3{font-size:15px;font-weight:700;color:#18b7b2;margin:18px 0 5px}\n.sb-pd p{margin:0 0 12px;font-size:15px}\n.sb-pd ul{margin:0 0 12px;padding-left:20px}\n.sb-pd li{margin-bottom:6px;font-size:14px}\n.sb-pd .cards{display:grid;grid-template-columns:repeat(3,1fr);gap:12px;margin:14px 0 20px}\n.sb-pd .card{background:#f1faf9;border:1px solid #daf3f2;border-top:3px solid #18b7b2;border-radius:0 0 10px 10px;padding:14px}\n.sb-pd .card h3{margin:0 0 5px;font-size:13px;color:#111}\n.sb-pd .card p{margin:0;font-size:12px;color:#5b6b71}\n.sb-pd table{width:100%;border-collapse:collapse;font-size:14px;margin:14px 0 20px}\n.sb-pd th{background:#18b7b2;color:#fff;text-align:left;padding:9px 13px;font-weight:700}\n.sb-pd td{padding:9px 13px;border-bottom:1px solid #e2eceb;vertical-align:top}\n.sb-pd tr:nth-child(even) td{background:#f8fffe}\n.sb-pd td:first-child{font-weight:600;color:#111;width:35%}\n.sb-pd .qa{background:#f8fffe;border:1px solid #daf3f2;border-radius:8px;padding:14px 16px;margin:10px 0}\n.sb-pd .qa .q{font-weight:700;color:#111;margin:0 0 5px;font-size:14px}\n.sb-pd .qa .a{margin:0;font-size:13px;color:#444}\n.sb-pd .cta{background:linear-gradient(135deg,#e4f6f5,#f4fbfb);border:1px solid rgba(24,183,178,.2);border-radius:12px;padding:20px;margin-top:28px;text-align:center}\n.sb-pd .cta h3{margin:0 0 7px;font-size:17px;color:#111}\n.sb-pd .cta p{margin:0 0 14px;font-size:13px;color:#5b6b71}\n.sb-pd .btn{display:inline-block;background:#18b7b2;color:#fff!important;padding:9px 20px;border-radius:7px;font-weight:700;font-size:13px;text-decoration:none!important;margin:0 4px}\n.sb-pd .btn-o{display:inline-block;border:2px solid #18b7b2;color:#18b7b2!important;padding:7px 20px;border-radius:7px;font-weight:700;font-size:13px;text-decoration:none!important;margin:0 4px}\n.sb-pd a{color:#18b7b2;font-weight:600}\n@media(max-width:600px){.sb-pd .cards{grid-template-columns:1fr}}\n<\/style>\n<div class=\"sb-pd\">\n<h2>Product Overview<\/h2>\n<p>The <strong>Cell4Pharma Human BSEP Vesicle Kit (C4PVK-BSEP)<\/strong> provides inside-out membrane vesicles isolated from HEK293 cells transiently overexpressing the Bile Salt Export Pump (<strong>BSEP \/ ABCB11<\/strong>). BSEP is the primary canalicular efflux transporter for conjugated bile salts in hepatocytes \u2014 its inhibition by drugs is a well-established mechanism of drug-induced cholestatic liver injury (DILI). The kit enables ATP-dependent taurocholate transport studies and inhibition assays in a high-throughput format compatible with radiolabel, fluorescent, and LC-MS\/MS detection. It is designed for <strong>BSEP inhibition assessment and DILI risk characterization<\/strong> in accordance with FDA Drug Interaction Guidance (2017) and EMA Guideline on the Investigation of Drug Interactions (2013). Kit size: <strong>100 Reaktionen<\/strong>. Also available: cat and dog BSEP vesicle kits for comparative species studies. Manufactured by Cell4Pharma; available exclusively in the DACH region via SeamlessBio.<\/p>\n<h2>Transporter Profile<\/h2>\n<table>\n<thead>\n<tr>\n<th>Parameter<\/th>\n<th>Details<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Transporter name<\/td>\n<td>BSEP \u2014 Bile Salt Export Pump<\/td>\n<\/tr>\n<tr>\n<td>Synonyms<\/td>\n<td>ABCB11, Sister of P-glycoprotein (SPGP), ATP-binding cassette sub-family B member 11<\/td>\n<\/tr>\n<tr>\n<td>Gen<\/td>\n<td>ABCB11<\/td>\n<\/tr>\n<tr>\n<td>Transporter family<\/td>\n<td>ABC (ATP-binding cassette) \u2014 efflux transporter, full-transporter<\/td>\n<\/tr>\n<tr>\n<td>ATP\/AMP-Verh\u00e4ltnis<\/td>\n<td>&gt;10 (guaranteed)<\/td>\n<\/tr>\n<tr>\n<td>Tissue expression<\/td>\n<td>Canalicular plasma membrane of hepatocytes (liver-exclusive expression)<\/td>\n<\/tr>\n<tr>\n<td>Known substrates<\/td>\n<td>Taurocholate (TCA), taurochenodeoxycholate, glycocholate, taurolitocholate-3-sulfate (TLCS), pravastatin, conjugated monovalent bile salts<\/td>\n<\/tr>\n<tr>\n<td>Known inhibitors<\/td>\n<td>Cyclosporin A, bosentan, troglitazone, glibenclamide, rifampicin<\/td>\n<\/tr>\n<tr>\n<td>Disease relevance<\/td>\n<td>Inherited cholestasis (PFIC2, BRIC2); drug-induced cholestatic DILI \u2014 primary BSEP inhibition mechanism<\/td>\n<\/tr>\n<tr>\n<td>Regulatory relevance<\/td>\n<td>FDA (2017) and EMA (2013) DDI guidance \u2014 BSEP inhibition assessment recommended for hepatotoxic DILI risk characterization<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Technische Daten<\/h2>\n<table>\n<thead>\n<tr>\n<th>Parameter<\/th>\n<th>Spezifikation<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Host cell<\/td>\n<td>HEK293 (human embryonic kidney) \u2014 transient overexpression<\/td>\n<\/tr>\n<tr>\n<td>Vesicle type<\/td>\n<td>Inside-out membrane vesicles<\/td>\n<\/tr>\n<tr>\n<td>Kit size<\/td>\n<td>100 reactions per kit<\/td>\n<\/tr>\n<tr>\n<td>ATP\/AMP-Verh\u00e4ltnis<\/td>\n<td>&gt;10 (lot-specific, guaranteed)<\/td>\n<\/tr>\n<tr>\n<td>Detection compatibility<\/td>\n<td>Radiolabel (\u00b3H\/\u00b9\u2074C), fluorescent substrates, LC-MS\/MS<\/td>\n<\/tr>\n<tr>\n<td>Assay format<\/td>\n<td>Vesicular transport assay \u2014 high-throughput compatible (96-well format)<\/td>\n<\/tr>\n<tr>\n<td>Species variants<\/td>\n<td>Human BSEP (C4PVK-BSEP); cat BSEP; dog BSEP \u2014 available on request<\/td>\n<\/tr>\n<tr>\n<td>Recommended control<\/td>\n<td>Human Control Vesicle Kit (C4PVK009) \u2014 negative control<\/td>\n<\/tr>\n<tr>\n<td>Lagerung<\/td>\n<td>\u221280 \u00b0C<\/td>\n<\/tr>\n<tr>\n<td>Manufacturer<\/td>\n<td>Cell4Pharma<\/td>\n<\/tr>\n<tr>\n<td>DACH distributor<\/td>\n<td>SeamlessBio (exclusive)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Kit Contents<\/h2>\n<table>\n<thead>\n<tr>\n<th>Komponente<\/th>\n<th>Details<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vesicle vial<\/td>\n<td>BSEP-overexpressing HEK293-derived inside-out membrane vesicles \u2014 100 reactions<\/td>\n<\/tr>\n<tr>\n<td>AMP-ATP solution<\/td>\n<td>100 mM \u2014 Cell4Pharma<\/td>\n<\/tr>\n<tr>\n<td>Assay buffer<\/td>\n<td>Cell4Pharma optimised formulation<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Anwendungen<\/h2>\n<table>\n<thead>\n<tr>\n<th>Anwendung<\/th>\n<th>Description<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>BSEP inhibition \/ DILI risk assessment<\/strong><\/td>\n<td>IC\u2085\u2080 determination for BSEP inhibition using taurocholate as probe substrate \u2014 primary in vitro screen for drug-induced cholestatic hepatotoxicity risk; supports DILI risk classification alongside clinical transaminase data<\/td>\n<\/tr>\n<tr>\n<td><strong>DDI characterization (FDA\/EMA)<\/strong><\/td>\n<td>Vesicular transport assays to assess whether a new molecular entity (NME) inhibits BSEP-mediated bile salt efflux \u2014 supports IND, NDA, and MAA submissions per FDA (2017) and EMA (2013) transporter DDI guidance<\/td>\n<\/tr>\n<tr>\n<td><strong>Substrate identification<\/strong><\/td>\n<td>ATP-dependent uptake assays to confirm active BSEP-mediated transport of candidate compounds \u2014 identifies hepatically cleared drugs that depend on BSEP for canalicular secretion<\/td>\n<\/tr>\n<tr>\n<td><strong>Comparative species studies<\/strong><\/td>\n<td>Cross-species BSEP inhibition profiling using human, cat, and dog BSEP vesicles \u2014 supports preclinical DILI species translation and veterinary drug safety assessment<\/td>\n<\/tr>\n<tr>\n<td><strong>High-throughput screening<\/strong><\/td>\n<td>96-well compatible format for screening compound libraries for BSEP inhibition \u2014 compatible with radiolabelled taurocholate (\u00b3H-TCA), fluorescent substrates, and LC-MS\/MS quantification<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Einhaltung gesetzlicher Vorschriften<\/h2>\n<p>BSEP (ABCB11) inhibition is a mechanistically established cause of drug-induced cholestatic liver injury (DILI). The <strong>FDA Drug Interaction Guidance (2017)<\/strong> und die <strong>EMA Guideline on the Investigation of Drug Interactions (2013)<\/strong> recommend in vitro BSEP inhibition assessment for new molecular entities (NMEs) with significant hepatic exposure, particularly those associated with cholestatic signal in clinical or preclinical studies. Unlike other DDI transporters where both substrate and inhibitor status are assessed, BSEP evaluation focuses primarily on inhibition \u2014 because BSEP inhibition by a drug reduces bile acid efflux, leading to intracellular bile acid accumulation and hepatocyte injury. The guaranteed ATP\/AMP ratio &gt;10 confirms active transport function and supports data quality requirements for DILI risk characterization packages submitted to regulatory agencies.<\/p>\n<h2>Available Formats<\/h2>\n<table>\n<thead>\n<tr>\n<th>Format<\/th>\n<th>Reactions<\/th>\n<th>Art<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Bausatz<\/td>\n<td>100 Reaktionen<\/td>\n<td>Human BSEP<\/td>\n<\/tr>\n<tr>\n<td>Bausatz<\/td>\n<td>100 Reaktionen<\/td>\n<td>Cat BSEP \u2014 on request<\/td>\n<\/tr>\n<tr>\n<td>Bausatz<\/td>\n<td>100 Reaktionen<\/td>\n<td>Dog BSEP \u2014 on request<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Key Benefits<\/h2>\n<div class=\"cards\">\n<div class=\"card\">\n<h3>Guaranteed Activity<\/h3>\n<p>ATP\/AMP ratio &gt;10 guaranteed per lot \u2014 confirms active BSEP-mediated taurocholate transport and assay suitability for DILI risk characterization and regulatory submissions.<\/p>\n<\/div>\n<div class=\"card\">\n<h3>Vollst\u00e4ndige Dokumentation<\/h3>\n<p>Lot-specific CoA with ATP\/AMP ratio \u2014 from Cell4Pharma ISO-certified facilities. Additional regulatory documents on request.<\/p>\n<\/div>\n<div class=\"card\">\n<h3>DACH Expert Support<\/h3>\n<p>Exclusive DACH distributor via SeamlessBio \u2014 scientific support for assay setup, DILI risk assessment workflows, and regulatory submission queries. 48h response.<\/p>\n<\/div>\n<\/div>\n<h2>\u00c4hnliche Produkte<\/h2>\n<table>\n<thead>\n<tr>\n<th>Produkt<\/th>\n<th>Verwendung<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><a href=\"https:\/\/seamlessbio.de\/de\/abc-transporter-vesicle-kits\/\">Human Control Vesicle Kit (C4PVK009)<\/a><\/td>\n<td>Recommended negative control for BSEP vesicular transport assays<\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/seamlessbio.de\/de\/abc-transporter-vesicle-kits\/\">Human MRP2 Vesicle Kit (C4PVK-MRP2)<\/a><\/td>\n<td>MRP2\/ABCC2 hepatic efflux \u2014 parallel canalicular transporter assessment alongside BSEP<\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/seamlessbio.de\/de\/kit-fur-humane-pgp-vesikel\/\">Human P-gp Vesicle Kit (C4PVK010)<\/a><\/td>\n<td>P-gp\/ABCB1 efflux \u2014 complete ABC transporter DDI panel<\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/seamlessbio.de\/de\/bcrp-vesikel-kit\/\">Human BCRP Vesicle Kit (C4PVK-BCRP)<\/a><\/td>\n<td>BCRP\/ABCG2 efflux \u2014 intestinal and hepatic efflux transporter panel<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>H\u00e4ufig gestellte Fragen<\/h2>\n<div class=\"qa\">\n<p class=\"q\">Why is BSEP inhibition assessed differently from other DDI transporters such as P-gp or BCRP?<\/p>\n<p class=\"a\">Unlike P-gp and BCRP \u2014 where both substrate and inhibitor status of the investigational drug are evaluated \u2014 BSEP assessment in the regulatory context focuses primarily on inhibition. This is because BSEP&#8217;s physiological role is highly specific: it is the dominant canalicular efflux transporter for conjugated bile salts in hepatocytes, and its inhibition by a drug causes intracellular bile acid accumulation, leading to cholestatic liver injury (DILI). A drug is rarely a BSEP substrate itself; the clinical concern is whether it inhibits BSEP-mediated bile acid efflux in patients. FDA (2017) and EMA (2013) guidance therefore recommend BSEP inhibition IC\u2085\u2080 determination using the vesicular transport assay with taurocholate as the probe substrate as the primary in vitro DILI risk screen.<\/p>\n<\/div>\n<div class=\"qa\">\n<p class=\"q\">Which probe substrate is used for BSEP vesicular transport inhibition assays?<\/p>\n<p class=\"a\">Taurocholate (TCA, taurocholic acid) is the standard probe substrate for BSEP vesicular transport assays, used in radiolabelled form (\u00b3H-taurocholate) in the majority of regulatory DDI studies. Taurocholate is a primary conjugated bile acid, a physiological BSEP substrate, and is cited in both FDA and EMA guidance as the reference probe. Taurolitocholate-3-sulfate (TLCS) is used as an alternative probe substrate when taurocholate transport signal is insufficient. For fluorescence-based detection, fluorescent bile acid analogues compatible with the Cell4Pharma assay format are available. The kit is compatible with all standard probe substrates and detection methods.<\/p>\n<\/div>\n<div class=\"qa\">\n<p class=\"q\">What IC\u2085\u2080 threshold is considered clinically relevant for BSEP inhibition?<\/p>\n<p class=\"a\">Regulatory agencies do not specify a single fixed IC\u2085\u2080 cut-off for BSEP inhibition; rather, BSEP inhibition data are interpreted in the context of total hepatic drug concentration versus the measured IC\u2085\u2080. A commonly applied risk classification framework (Dawson et al., Toxicol Sci 2012) defines IC\u2085\u2080 values below 25 \u00b5M as potentially relevant for drugs with hepatic exposure, particularly when combined with clinical cholestatic signals or elevated ALP\/bilirubin in preclinical studies. The key regulatory output is the IC\u2085\u2080 value and the relationship between systemic and hepatic drug exposure \u2014 not a binary pass\/fail threshold. The Cell4Pharma BSEP kit enables precise IC\u2085\u2080 determination across a full concentration range, which is the data format expected in DILI risk characterization packages for NDA\/MAA submissions.<\/p>\n<\/div>\n<div class=\"qa\">\n<p class=\"q\">Are cat and dog BSEP vesicle kits available, and when are they needed?<\/p>\n<p class=\"a\">Yes \u2014 Cell4Pharma offers cat and dog BSEP vesicle kits alongside the human kit, available via SeamlessBio on request. Comparative BSEP inhibition studies across species are used in two scenarios: first, in veterinary drug safety assessment where the target species is a companion animal and human BSEP data alone are insufficient; and second, in preclinical DILI species translation, where discordance between rat and dog cholestatic signals is investigated through direct species comparison of BSEP inhibition potency. BSEP amino acid sequence and substrate specificity differ across species, so human IC\u2085\u2080 values do not always predict dog or cat BSEP sensitivity \u2014 making species-specific kits the appropriate tool when cross-species DILI characterization is required.<\/p>\n<\/div>\n<div class=\"qa\">\n<p class=\"q\">Can the BSEP vesicle kit be used as part of a broader ABC transporter DDI panel?<\/p>\n<p class=\"a\">Yes \u2014 BSEP is routinely assessed as part of a complete hepatic transporter DDI panel alongside P-gp (ABCB1), BCRP (ABCG2), and MRP2 (ABCC2). While P-gp, BCRP, and MRP2 are assessed for both substrate and inhibitor potential of the investigational drug, BSEP is assessed for inhibition only. Cell4Pharma&#8217;s ABC transporter vesicle kit range \u2014 P-gp, BCRP, BSEP, MRP1, MRP2, MRP5 \u2014 shares a common assay format and buffer system, enabling parallel processing within the same experiment and reducing total assay development time. The Human Control Vesicle Kit (C4PVK009) serves as the single matched negative control across all transporter assays in the panel. All kits are available via SeamlessBio for the DACH region.<\/p>\n<\/div>\n<div class=\"cta\">\n<h3>Request a Quote or Technical Information<\/h3>\n<p>48h response \u00b7 DACH exclusive via SeamlessBio \u00b7 Full lot documentation \u00b7 Cell4Pharma quality<\/p>\n<p>  <a href=\"https:\/\/seamlessbio.de\/de\/request-quote\/\" class=\"btn\">Request Quote \u2192<\/a><br \/>\n  <a href=\"https:\/\/seamlessbio.de\/de\/abc-transporter-vesicle-kits\/\" class=\"btn-o\">All ABC Transporter Kits \u2192<\/a>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Human BSEP Vesicle Kit (HEK293-derived). Available in 100. Price on request \u2014 contact our team for availability, batch documentation and delivery. <\/p>\n<div style='margin-top:12px'><a href='https:\/\/seamlessbio.de\/de\/sammelreservierung\/' style='display:block;background:#fff;border:2px solid #18b7b2;color:#18b7b2;padding:10px 24px;border-radius:8px;font-weight:700;font-size:14px;text-decoration:none;text-align:center;'>Test Sample &amp; Batch Reservation \u2192<\/a><\/div>","protected":false},"featured_media":3698,"template":"","meta":{"_eb_attr":""},"product_brand":[252],"product_cat":[73],"product_tag":[],"class_list":["post-3559","product","type-product","status-publish","has-post-thumbnail","product_brand-cell4pharma","product_cat-dmpk-transporter-kits","first","instock","taxable","shipping-taxable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Human BSEP Vesicle Kit HEK293 | SeamlessBio<\/title>\n<meta name=\"description\" content=\"Human BSEP (ABCB11) vesicle kit from HEK293 cells. 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