Delipidated human serum has triglycerides and LDL selectively removed by dextran sulfate-MgCl₂ precipitation — reducing lipid content to near-zero while preserving endogenous proteins, albumin, and immunoglobulins. This base is used in CLSI EP7 lipemia interference studies: the delipidated matrix is spiked with defined intralipid or triglyceride concentrations to test at what lipid level the assay signal deviates by more than 10% from the lipemia-free result. Standard serum cannot be used for this — it has variable baseline lipid content that confounds the interference calculation.

Double Charcoal Treated serum is required when developing or validating immunoassays for endogenous small molecules — steroid hormones (oestradiol, testosterone, progesterone, cortisol), thyroid hormones (T3, T4, TSH), drugs of abuse, vitamins, and other small lipophilic analytes. Charcoal adsorption strips these endogenous molecules below assay detection limits, creating a hormone/drug-free serum matrix into which calibrators can be added at known concentrations for standard curve preparation. Without charcoal treatment, endogenous hormone background inflates the zero-calibrator signal and compresses the standard curve.

Yes — SeamlessBio human sera are sourced from EU Blood Directive-qualified donor centres and supplied with the documentation package required for IVDR technical files: CoA, Certificate of Origin (EU blood centre), viral screening panel results (HIV 1/2 NAT + serology, HBsAg, anti-HCV + HCV RNA, syphilis), and donor qualification confirmation. Batch reservation is available for extended IVD kit production runs requiring consistent lot specification across multiple kit batches.