What ABC Transporter Vesicle Kits does SeamlessBio supply?

SeamlessBio supplies ABC Transporter Vesicle Kits for BSEP, P-gp (MDR1), MRP1, MRP2, MRP3, MRP4, MRP5, MRP8 and Control Vesicles. All kits from Cell4Pharma — validated for DDI studies and regulatory submissions (FDA, EMA, ICH M12). SeamlessBio is the exclusive DACH distributor.

What is ciPTEC and for which transporters is it validated?

ciPTEC (conditionally immortalised proximal tubule epithelial cells) are human kidney proximal tubule cells expressing OAT1, OAT3, OCT2, MATE1, MATE2-K and P-gp. Ideal for renal DDI studies, nephrotoxicity screening and transporter kinetics in a polarised epithelial model.

ABC Transporter Vesicle Kits · ciPTEC · DDI Studies · Regulatory Submissions · DACH Distributor

DMPK ABC Transporter Assays

ABC Transporter Vesicle Kits and ciPTEC cell lines for DMPK transporter assays — DDI studies, regulatory submissions and renal transporter research. SeamlessBio is the exclusive DACH distributor for Cell4Pharma products.

Request Quote or Information All DMPK Products

9 Transporter Kits

BSEP · P-gp · MRP1 · MRP2 · MRP3 · MRP4 · MRP5 · MRP8 · Control. Full DDI panel coverage.

Regulatory Validated

FDA DDI Guidance 2020 · EMA DDI Guideline · ICH M12. Suitable for IND and NDA/MAA submissions.

ciPTEC Cell Lines

Human renal proximal tubule cells — OAT1, OAT3, OCT2, MATE1, MATE2-K, P-gp. Physiologically relevant model.

DACH Distributor

SeamlessBio — exclusive DACH distributor for Cell4Pharma. German-language support, EU lead times.

ABC Transporter Vesicle Kits — Full Panel

Kit	Transporter	Regulatory Relevance	Typical Substrate
BSEP Vesicle Kit	BSEP (ABCB11)	FDA/EMA DILI risk, bile salt transport	Taurocholate
P-gp Vesicle Kit	P-glycoprotein (MDR1/ABCB1)	FDA/EMA DDI — mandatory for NCE	N-methyl quinidine
MRP1 Vesicle Kit	MRP1 (ABCC1)	Tissue distribution, DDI	LTC4
MRP2 Vesicle Kit	MRP2 (ABCC2)	FDA/EMA DDI — hepatic efflux	Estradiol-17β-glucuronide
MRP3 Vesicle Kit	MRP3 (ABCC3)	Hepatic/renal efflux, DDI	Estradiol-17β-glucuronide
MRP4 Vesicle Kit	MRP4 (ABCC4)	Renal efflux, DDI studies	PMEA
MRP5 Vesicle Kit	MRP5 (ABCC5)	Research — nucleotide efflux	cGMP
MRP8 Vesicle Kit	MRP8 (ABCC11)	Research — secretory transport	cGMP
Control Vesicle Kit	Empty vector control	Mandatory negative control	—

ciPTEC — Renal Transporter Model

ciPTEC (conditionally immortalised proximal tubule epithelial cells) are human kidney-derived cells expressing endogenous renal transporters in a physiologically relevant polarised epithelial monolayer.

Unlike overexpression systems, ciPTEC express transporters at physiological ratios — making them the preferred model for renal DDI studies and nephrotoxicity screening where endogenous transporter expression is critical.

OAT1 (SLC22A6) — organic anion uptake
OAT3 (SLC22A8) — organic anion uptake
OCT2 (SLC22A2) — organic cation uptake
MATE1 (SLC47A1) — organic cation efflux
MATE2-K (SLC47A2) — organic cation efflux
P-gp (ABCB1) — ABC efflux transporter

Vesicle Kits vs ciPTEC

Parameter	Vesicle Kits	ciPTEC
Transporter expression	Overexpression	Endogenous
Model type	Isolated membrane	Polarised epithelium
Transporters covered	ABC efflux	OAT, OCT, MATE, P-gp
Regulatory use	FDA/EMA DDI	Renal DDI, nephrotox
Throughput	High	Medium
Best for	Rapid DDI screening	Renal context assays

Regulatory DDI Workflow — SeamlessBio Products

DDI Study Type	SeamlessBio Product	Regulatory Guideline
P-gp DDI (mandatory)	P-gp Vesicle Kit	FDA 2020 · EMA 2012 · ICH M12
BCRP DDI (mandatory)	BCRP Vesicle Kit	FDA 2020 · EMA 2012 · ICH M12
MRP2 DDI (hepatic)	MRP2 Vesicle Kit	FDA 2020 · EMA 2012
BSEP inhibition (DILI)	BSEP Vesicle Kit	FDA DILI Guidance
Renal OAT1/3 DDI	ciPTEC	FDA 2020 · EMA 2012 · ICH M12
Renal OCT2 DDI	ciPTEC	FDA 2020 · EMA 2012 · ICH M12
Renal MATE1/2-K DDI	ciPTEC	FDA 2020 · EMA 2012 · ICH M12

Frequently Asked Questions

Which transporters must be tested for regulatory submissions?

FDA and EMA require DDI assessment for: P-gp, BCRP (efflux); OAT1, OAT3, OCT2 (renal uptake); MATE1, MATE2-K (renal efflux); OCT1 (hepatic uptake); OATP1B1, OATP1B3 (hepatic uptake). SeamlessBio supplies vesicle kits and ciPTEC covering the full panel.

Are the kits validated for regulatory submissions?

Yes — Cell4Pharma ABC Transporter Vesicle Kits are validated for DDI studies per FDA Drug Interaction Guidance (2020), EMA DDI Guideline (2012) and ICH M12. Full validation package on request.

What is ciPTEC and why use it for renal DDI?

ciPTEC are human kidney proximal tubule cells expressing OAT1, OAT3, OCT2, MATE1, MATE2-K and P-gp at endogenous levels in a polarised epithelial monolayer — the physiologically relevant model for renal transporter DDI studies and nephrotoxicity screening.

Is SeamlessBio the only supplier in DACH?

Yes — SeamlessBio is the exclusive DACH distributor for Cell4Pharma ABC Transporter Vesicle Kits and ciPTEC cell lines. German-language support, EU lead times, no import delays.