NaivaCore — iPSC Medium

What is the difference between naïve and primed iPSC culture?

Naïve iPSCs correspond to the pre-implantation epiblast (day 4–6) with both X chromosomes active. Primed iPSCs are post-implantation with random X inactivation. Naïve cells can differentiate into trophoblast; primed cells cannot. NaivaCore is specifically formulated to maintain and expand cells in the naïve ground state.

What is HENSM and why does it matter for naïve stem cell culture?

HENSM (Human Extendable Naïve Stem Cell Medium) is a defined medium formulation that supports stable, feeder-free naïve pluripotency in human iPSCs and ESCs. It enables long-term expansion without spontaneous differentiation, making it suitable for ATMP upstream research and reproducible cell-based assays.

Can NaivaCore be used for naïve reprogramming from primed iPSCs?

Yes. NaivaCore supports conversion of primed iPSCs to the naïve ground state. For detailed component information and reprogramming protocols, see the NaivaCore technical overview.

Why is NaivaCore only available via SeamlessBio in the EU?

SeamlessBio is the exclusive EU distributor for NaivaCore — providing direct supply from certified partner facilities without US import delays or MTA requirements. Orders ship across EU, UK and Switzerland with full batch documentation.

Which cell culture media does SeamlessBio offer for iPSC and stem cell applications?

SeamlessBio supplies a range of specialised cell culture media for iPSC maintenance, naïve reprogramming and ATMP upstream research. NaivaCore is our flagship naïve iPSC medium.