Human Plasma — Type AB, Male Donors
Plasma from certified male AB blood-type donors — free of anti-A and anti-B antibodies. The preferred plasma format for CAR-T expansion, NK cell manufacturing, MSC culture and any immunologically sensitive cell therapy application. EU and US origin, with batch reservation for ATMP programmes.
Related products — find the right format
No Anti-A/B Antibodies
AB blood type confirmed — universally compatible with human cells of any ABO blood group. No alloantibody-mediated interference.
Male Donors Only
Reduced sex hormone variability lot-to-lot — stable oestrogen and progesterone background for hormone-sensitive protocols.
Herkunft: EU und USA
Certified donor centres in Europe and the United States — specify origin at order. Full IVDR and GMP-process documentation available.
Sammelreservierung
Lot reservation for ATMP programmes — no prepayment during evaluation. EU cold stock, call-off in partial deliveries as needed.
Why AB blood type — and why male donors only?
Blood group AB is the only group carrying neither anti-A nor anti-B antibodies. In all other blood groups — A, B and O — these alloantibodies circulate in plasma and can activate complement, lyse cells bearing the corresponding antigen, and create non-specific immune effects in culture systems that are difficult to distinguish from assay signal.
Restricting the donor pool to male donors addresses a second source of variability: sex hormone concentrations. Female plasma contains cyclically fluctuating oestrogens, progesterone and FSH/LH — hormones that activate steroid receptors in cultured cells, alter proliferation rates and confound results in hormone-sensitive assays. Male donors provide a consistently low and stable sex hormone background.
Together, AB blood type and male-only donor selection give the lowest alloantibody background and most consistent hormonal environment available in non-processed human plasma — which is why AB male plasma is specified in CAR-T protocols and ATMP workflows where regulatory agencies increasingly scrutinise animal-derived component profiles.
See also: Menschliches Serum, OTC, Typ AB, männlich — the serum equivalent, without coagulation factors, with higher growth factor release from platelet degranulation during clotting.
Typische Anwendungsbereiche
- CAR-T cell manufacturing — ex vivo T cell activation and expansion media supplement
- NK cell expansion — allogeneic cell therapy programmes
- MSC expansion in plasma-supplemented, xeno-free protocols
- IVD calibrator manufacturing — universal AB matrix avoids alloantibody interference
- Complement activity studies requiring AB background
- Cell therapy process development requiring defined, consistent plasma supplement
- Haematopoietic stem cell (HSC) culture and expansion
AB male plasma vs. other plasma formats
| Parameter | AB Male Plasma | Mixed Blood Group Plasma | Mixed Gender Plasma |
|---|---|---|---|
| Anti-A antibodies | Absent | Present (A/O donors) | Variable |
| Anti-B antibodies | Absent | Present (B/O donors) | Variable |
| Oestrogen / progesterone | Low, stable | Low, stable | Fluctuating |
| Inter-lot hormonal variability | Niedrig | Niedrig | Moderate–High |
| Universal cell compatibility (any ABO) | Ja | Nein | Depends on mix |
| Preferred for CAR-T / ATMP | Ja | Not recommended | Not recommended |
Plasma vs. Serum — Type AB Male: SeamlessBio also supplies Menschliches Serum, OTC, Typ AB, männlich — produced from whole blood without anticoagulant, so it lacks coagulation factors but contains higher concentrations of platelet-released growth factors. For cell culture where coagulation factor activity is not required, off-the-clot serum is often specified. For assays requiring intact factor activity, use plasma.
Product specifications
| Article number | HPAB-M |
| Produkttyp | Human Plasma, Blood Group AB, Male Donors |
| Herkunft | EU or US — specify at order |
| Donor selection | Male donors only, blood group AB confirmed by typing |
| Anti-A / Anti-B antibodies | Absent — confirmed by ABO blood group typing |
| Anticoagulant | EDTA (K2) · Citrate (3.2%) · ACD-A — specify at order |
| Available formats | Single donor units (~200–450 mL) · Pooled AB male lots · Bulk on request |
| Lagerung | Fresh-frozen −20°C · −80°C on request |
| Virus-Screening | HIV-1/2 Ab, HBsAg, HCV Ab, Syphilis — all negative |
| Dokumentation | CoA, CoO, MSDS, viral screening report · GMP process documentation on request |
| Minimum order | No minimum order quantity |
| Zulassungsstatus | For research and IVD manufacturing use · GMP process development documentation available |
Frequently asked questions
Is AB male plasma available as single units or pooled lots — or both?
Both. Single AB male donor units provide per-donor traceability and are suitable for reference panel construction. Pooled AB male lots (multiple AB male donors combined) provide a larger homogeneous volume for manufacturing and scale-up. State your preference and required volume at enquiry.
Which anticoagulant should I specify for CAR-T or NK cell expansion media?
ACD-A (Acid Citrate Dextrose Formula A) is the preferred anticoagulant for cell therapy plasma used as a media supplement — less cytotoxic at typical usage concentrations than EDTA, and commonly specified in PBMC and NK cell protocols. EDTA is standard for IVD applications. Specify your requirement at order — all three formats are available.
Can this plasma support a GMP cell therapy manufacturing process?
SeamlessBio AB male plasma is available with extended documentation to support GMP process development and manufacturing qualification — including TSE statements, donor consent documentation and manufacturing site certification where available. Discuss your specific regulatory submission requirements directly with us. Contact info@seamlessbio.de.
What is the difference between this product and Human Serum OTC Type AB Male?
Plasma is collected with anticoagulant before centrifugation and retains all coagulation factors including fibrinogen. Off-the-clot serum is obtained after natural clotting — no coagulation factors remain, but platelets degranulate during clotting and release additional growth factors (PDGF, TGF-β) into the serum. For cell culture supplementation, serum is often preferred. For applications requiring intact coagulation factor activity, use plasma. See Menschliches Serum, OTC, Typ AB, männlich →
Not sure which AB male format fits your protocol?
Contact our team — we advise on plasma vs. serum, anticoagulant format, single units vs. pooled lots, and provide a free test volume before you commit.
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