Description
Product Overview
SeamlessBio Fetal Bovine Serum – Low Endotoxin (<1 EU/mL) is sourced from certified herds in South America and processed under controlled conditions to reduce endotoxin levels below 1 EU/mL — more than 10× lower than standard FBS.
Each batch is sterile filtered at 0.1 µm, ensuring high purity and consistent performance for endotoxin-sensitive applications. Learn more about what FBS is and why endotoxin levels matter in cell culture.
Low Endotoxin FBS: Specifications
- Origin: South America — certified, traceable donor herds
- Endotoxin level: <1 EU/mL (verified by LAL assay)
- Filtration: 0.1 µm sterile filtered
- Processing: Standard (non-heat-inactivated)
- Sterility tested, mycoplasma tested
- Storage: –20 °C (cold chain required)
- Documentation: CoA, BSE/TSE statement, COO, sterility certificate available
Applications
- Vaccine production and viral vector manufacturing
- Cell therapy and ATMP manufacturing
- GMP-adjacent bioprocessing where endotoxin control is critical
- Sensitive primary cell and stem cell culture
- Recombinant protein production — see our full FBS portfolio
Available Formats
| Format | Size |
|---|---|
| Unit | 100 mL |
| 500 mL |
Key Benefits
Batch Reservation
Reserve validated lots up to 36 months for reproducible long-term workflows.
Full Documentation
CoA, BSE/TSE, sterility certificate — supplied by ISO 9001 and ISO 13485 certified partner facilities. Additional documents on request.
EU & Swiss Supply
Sourced from certified EU and Swiss partner facilities — fast delivery across EU, UK and Switzerland, full documentation included.
Frequently Asked Questions
What does <1 EU/mL endotoxin mean and why does it matter?
Endotoxins (lipopolysaccharides, LPS) are bacterial cell wall fragments that trigger strong immune responses even at sub-nanogram concentrations. Standard FBS typically contains 5–25 EU/mL; our Low Endotoxin FBS is tested below 1 EU/mL by the LAL (Limulus Amebocyte Lysate) assay. This is critical for vaccine production, cell therapy, and any GMP-adjacent process where endotoxin contamination can compromise product safety or cell viability.
Is Low Endotoxin FBS suitable for GMP manufacturing?
While FBS itself is not a GMP-certified ingredient, our Low Endotoxin FBS is sourced from ISO 9001 and ISO 13485 certified partner facilities with full batch documentation. It is widely used in GMP-adjacent research and process development. For regulated manufacturing, batch reservation and additional regulatory documentation are available on request.
How does South America origin FBS compare to US or Australian FBS?
South American FBS (primarily Brazil and Argentina) offers a favorable BSE risk profile, high growth promotion, and competitive pricing. It is EMEA-accepted and widely used in European biopharmaceutical manufacturing. Australian FBS carries the lowest BSE risk (OIE-certified BSE-free country) but at higher cost. US origin FBS is USDA-approved with strong regulatory documentation. The best choice depends on your application, regulatory requirements, and budget.
Can I reserve a specific batch for long-term studies?
Yes — batch reservation is available for up to 36 months. This guarantees lot-to-lot consistency for longitudinal studies, process validation, or manufacturing runs that require a fixed, validated FBS lot. Contact our team with your required volume and timeline.
What documentation is included with Low Endotoxin FBS?
Every order ships with a Certificate of Analysis (CoA) including endotoxin test results. Additional documentation — BSE/TSE statement, Certificate of Origin (COO), sterility certificate, and mycoplasma test report — is available on request.
Request a Quote or Sample
48h response · EU & Swiss Supply · Batch reservation available · Full documentation
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