Quick Definition
What is Human AB Male Serum?: Human AB Male Serum is human AB serum collected exclusively from male donors, eliminating hormones present in female donors — particularly hCG, estradiol, progesterone, and cycle-dependent protein variations. It is used in hormone-sensitive immunoassays, testosterone and PSA assay development, and any application where female donor hormone fluctuations would confound results.
Which assays require male-only human serum?
- Testosterone immunoassay: calibrators and QC materials must be in male serum for physiologically relevant concentrations
- PSA assay development: PSA is prostate-derived and absent from female serum
- hCG pregnancy test: female donor serum may contain low hCG creating background in negative controls
- SHBG, LH, FSH assays: female cycle variation makes mixed-donor serum insufficiently reproducible for calibrators
Key Facts
- Collected from male donors only — no hCG, no LH cycle variation, stable estradiol/progesterone baseline
- Testosterone levels: male donors 300–1,000 ng/dL vs female 15–70 ng/dL — essential for testosterone immunoassay calibration
- PSA (prostate-specific antigen) present only in male serum — required for PSA IVD assay development
- hCG absent — critical for pregnancy test assay development where female serum hCG would cause false positives in controls
- Cycle-dependent protein variation eliminated — female serum SHBG, DHEA-S, FSH vary across the menstrual cycle
- Available from SeamlessBio: type AB male, native and heat inactivated, EU origin
Further Reading
SeamlessBio GmbH · Passau, Germany · info@seamlessbio.de
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