Neugeborenen-Kälberserum (NCS)
Collected from bovine calves within the first 10 days of life — lower IgG than standard Calf Serum, higher growth factor content, and 30–50% cheaper than FBS. Available in US and Australian origin with complete BSE/TSE documentation.
Low IgG Background
Collected within the first 10 days of life — before full maternal immunoglobulin transfer — delivering significantly lower IgG than standard Calf Serum.
30–50% Cheaper than FBS
Equivalent growth performance for most standard immortalised cell lines at a fraction of the cost — the most cost-efficient serum when low IgG matters.
Complete BSE/TSE Certification
US origin with 9CFR CoA; Australian origin with EDQM CEP and OIE negligible BSE risk. Full documentation for regulated and research workflows.
EU & Swiss Cold-Chain
Fast temperature-controlled delivery across EU, UK and Switzerland. Batch reservation up to 36 months for long-term reproducibility.
Available NCS Origins
NCS — US Origin
Collected at USDA 9CFR licensed facilities from calves ≤10 days old. Sterile filtered at 0.2 µm, batch-tested for endotoxin, mycoplasma and BVDV. The most cost-efficient NCS option for research without strict regulatory documentation requirements.
- Origin: USA — USDA 9CFR licensed
- Donor age: ≤10 days
- Filtration: 0.2 µm sterile filtered
- BSE status: Controlled risk (OIE)
- Documentation: CoA, 9CFR CoA, TSE/BSE on request
- Formats: 50 mL · 100 mL · 500 mL · Bulk
NCS — Australia Origin
Australia has the highest available BSE/TSE biosafety profile — OIE negligible risk, no indigenous BSE ever detected. EDQM CEP available for EU regulatory submissions. Preferred for vaccine production, IVD manufacturing and GMP-adjacent workflows where maximum traceability is required.
- Origin: Australia — OIE negligible BSE risk
- Donor age: ≤10 days
- Filtration: 0.2 µm sterile filtered
- BSE status: Negligible (OIE) — no indigenous BSE
- Documentation: CoA, EDQM CEP, TSE/BSE statement included
- Formats: 50 mL · 100 mL · 500 mL · Bulk
When to choose NCS over CS or FBS
Newborn Calf Serum fills the gap between standard Calf Serum and FBS. Because calves are collected within the first 10 days of life — before maternal colostrum-derived IgG reaches full saturation — NCS has significantly lower immunoglobulin levels than CS (up to 6 months), while retaining moderate to high growth factor content.
For most standard immortalised cell lines, NCS is a direct drop-in FBS replacement at the same concentration (5–10%), with a recommended 2–3 passage adaptation. It is not recommended for primary cells, stem cells, or applications requiring the precise growth factor profile of FBS.
Where IgG background is irrelevant and maximum cost savings are the only driver, standard Calf Serum (CS) at 40–60% below FBS cost is the better choice.
NCS vs. CS vs. FBS at a glance
| Eigenschaft | NCS (≤10 d) | CS (≤6 mo) | FBS |
|---|---|---|---|
| IgG-Gehalt | Niedrig | Mäßig bis hoch | Sehr niedrig |
| Wachstumsfaktoren | Mäßig bis hoch | Mäßig | Highest |
| Cost vs. FBS | 30–50% saving | 40–60% saving | Quelle |
| Primary cells | Nicht empfohlen | Nicht empfohlen | ✔ Suitable |
| Stem cells | Nicht empfohlen | Nicht empfohlen | ✔ Suitable |
| Standard cell lines | ✔ Drop-in | ✔ Drop-in | ✔ Reference |
Common applications
- Routine mammalian cell line maintenance (CHO, HeLa, Vero, HEK293, BHK-21, MDCK)
- Immunoassay development — lower IgG reduces non-specific background
- Veterinary & agricultural research (bovine, ovine, porcine, equine)
- Large-scale cell banking (master & working cell banks)
- Bioreactor seed train cost optimisation (N-2 to N-1 stages)
- Any routine FBS application where reduced IgG background is preferred
Dokumentation verfügbar
- Certificate of Analysis (CoA) — lot-specific
- USDA 9CFR CoA (US origin)
- EDQM CEP (Australia origin)
- TSE/BSE risk assessment statement
- Ursprungszeugnis (CoO)
- Sicherheitsdatenblatt (SDB)
- Sterility & mycoplasma test protocols
- Batch reservation up to 36 months
Häufig gestellte Fragen
Request NCS — US or Australian Origin
48h response · Complete BSE/TSE documentation · Batch reservation up to 36 months · EU & Swiss cold-chain delivery
Request Quote →
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